3-Fluoro-N-methyl-D-aspartic acid (3F-NMDA) stereoisomers as conformational probes for exploring agonist binding at NMDA receptors

Chemistry - A European Journal

Volumn 18, Issue 28, 2012, Pages 8813-8819

  Chia, Poh Wai ^a   Livesey, Matthew R ^b   Slawin, Alexandra M Z ^a   Van Mourik, Tanja ^a   Wyllie, David J A ^b   O'Hagan, David ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

fluorine; glutamate receptors; molecular conformation; neurotransmitters; NMDA

Indexed keywords

BINDING CONFORMATIONS; BIOACTIVE COMPOUNDS; C-F BONDS; DIASTEREOISOMERS; GAUCHE CONFORMATION; GLUTAMATE RECEPTOR; IONOTROPIC GLUTAMATE RECEPTORS; MOLECULAR CONFORMATION; N-METHYL-D-ASPARTATE; NEUROTRANSMITTERS; NMDA; NMDA RECEPTOR; STEREO-SELECTIVE;

AMINO ACIDS; FLUORINE; STEREOCHEMISTRY;

CONFORMATIONS;

3 FLUORO N METHYL D ASPARTIC ACID; 3-FLUORO-N-METHYL-D-ASPARTIC ACID; DRUG DERIVATIVE; FLUORINATED HYDROCARBON; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYLASPARTIC ACID;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG POTENTIATION; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; HYDROCARBONS, FLUORINATED; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; N-METHYLASPARTATE; RECEPTORS, N-METHYL-D-ASPARTATE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863460309     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201200071     Document Type: Article

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