3-Fluoroaspartate and pyruvoyl-dependant aspartate decarboxylase: Exploiting the unique characteristics of fluorine to probe reactivity and binding

Chemistry - A European Journal

Volumn 16, Issue 33, 2010, Pages 10030-10041

  De Villiers, Jandré ^a   Koekemoer, Lizbé ^a   Strauss, Erick ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

Amino acids; Conformation analysis; Fluorinated substituents; Inhibitors; Lyases

Indexed keywords

ACTIVE SITE; ASPARTATES; BINDING ANALYSIS; BINDING PROFILES; COFACTORS; CONFORMATION ANALYSIS; DECARBOXYLASES; ELIMINATION REACTION; ENAMINES; ERYTHRO; FLUORINATED SUBSTITUENTS; INHIBITORS; LYASES; M. TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; PLP-DEPENDENT ENZYMES; PYRIDOXAL PHOSPHATES; SPECIFIC INHIBITORS;

AMINO ACIDS; BINDING SITES; CARBOXYLATION; CATALYSTS; ENZYME ACTIVITY; ENZYMES; ESCHERICHIA COLI; FLUORINE; ISOMERS; ORGANIC ACIDS; PROBES;

CONFORMATIONS;

3 FLUOROASPARTIC ACID; ASPARTATE 4-DECARBOXYLASE; ASPARTATE BETA DECARBOXYLASE; ASPARTIC ACID; BETA-FLUOROASPARTIC ACID; CARBOXYLYASE; DRUG DERIVATIVE; PYRUVIC ACID;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ASPARTIC ACID; BINDING SITES; CARBOXY-LYASES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN CONFORMATION; PYRUVIC ACID;

EID: 77956129769     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201000622     Document Type: Article

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