Protective effect of pravastatin against mercury induced vascular cells damage: Erythrocytes as surrogate markers

Environmental Toxicology and Pharmacology

Volumn 34, Issue 2, 2012, Pages 428-435

  Harisa, Gamaleldin I ^a,b   Alanazi, Fars K ^a   El Bassat, Randa A ^c   Malikd, Abdul ^d   Abdallah, Gamil M ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Al Azhar University   (Egypt)

^c UMM AL QURA UNIVERSITY   (Saudi Arabia)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Erythrocytes; Mercury; Nitric oxide; Oxidative stress; Pravastatin

Indexed keywords

CARBONYL DERIVATIVE; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MERCURY; PRAVASTATIN; SUPEROXIDE DISMUTASE; ANTIOXIDANT; HEMOGLOBIN; NITRITE; MERCURIC CHLORIDE; PROTEIN CARBONYL; UNCLASSIFIED DRUG;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DAMAGE; CELL FUNCTION; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ERYTHROCYTE; HUMAN; HUMAN CELL; LIPID PEROXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; CELL CULTURE; HEMATOCRIT; HEMOLYSIS; METABOLISM; POLLUTANT; PROTEIN CARBONYLATION; CELL LEVEL; DISEASE MARKER; NORMAL HUMAN; OXIDATION REDUCTION STATE;

SUID HERPESVIRUS 1;

ADULT; ANTIOXIDANTS; CATALASE; CELLS, CULTURED; ENVIRONMENTAL POLLUTANTS; ERYTHROCYTES; GLUTATHIONE PEROXIDASE; HEMATOCRIT; HEMOGLOBINS; HEMOLYSIS; HUMANS; MALONDIALDEHYDE; MERCURY; NITRITES; PRAVASTATIN; PROTEIN CARBONYLATION; SUPEROXIDE DISMUTASE;

EID: 84863460276     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2012.06.001     Document Type: Article

References (46)

1. Ademuyiwa, O., Ugbaja, R.N., Rotimi, S.O., Abam, E., Okediran, B.S., Dosumu, O.A., Onunkwor, B.O., 2007. Erythrocyte acetylcholinesterase activity as a surrogate indicator of lead-induced neurotoxicity in occupational lead exposure in Abeokuta. Nigeria. Environ. Toxicol. Pharmacol. 24 (2), 183-208.
2. Aebi, H., 1974. Catalase in Method of Enzymatic Analysis, vol. 2. Academic Press, New York, pp. 673-684.
3. Brandão, R., Lara, F.S., Pagliosa, L.B., Soares, F.A., Rocha, J.B., Nogueira, C.W., Farina, M., 2005. Hemolytic effects of sodium selenite and mercuric chloride in human blood. Drug Chem. Toxicol. 28 (4), 397-407.
4. Bukowska, B., Rychlik, B., Krokosz, A., Michaowicz, J., 2008. Phenoxy-herbicides induce production of free radicals in human erythrocytes: oxidation of dichlorodihydrofluorescine and dihydrorhodamine 123 by 2,4-d-Na and MCPA-Na. Food Chem. Toxicol. 46, 359-367.
5. Carvalho, F.A., Mesquita, R., Martins-Silva, J., Saldanha, C., 2004. Acetylcholine and choline effects on erythrocyte nitrite and nitrate levels. J. Appl. Toxicol. 24 (6), 419-427.
6. Chen, X., Touyz, R.M., Park, J.B., Schiffrin, E.L., 2001. Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR. Hypertension 38 (3 Pt 2), 606-611.
7. Chikezie, P.C., Uwakwe, A.A., Monago, C.C., 2009. Studies of human HbAA erythrocytes osmotic fragility index of non malarious blood in the presence of five antimalarial drugs. J. Cell and Animal Biol. 3, 39-43.
8. Cimen, M.Y., 2008. Free radical metabolism in human erythrocytes. Clin. Chim. Acta 390 (1-2), 1-11.
9. Clarkson, T.W., 2002. The three modern faces of mercury. Environ. Health Perspect. 110 (Suppl. 1), 11-23.
10. De Souza Queiroz, M.L., Pena, S.C., Salles, T.S., 1998. Abnormal antioxidant system in erythrocytes of mercury exposed workers. Hum. Exp. Toxicol. 17, 225-230.
11. Durham, H.D., Minotti, S., Caporicci, E., 1997. Sensitivity of platelet microtubules to disassembly by methylmercury. J. Toxicol. Environ. Health 48, 57-69.
12. Formigari, A., Irato, P., Santon, A., 2007. Zinc, Antioxidant systems and metallothionein in metal mediated-apoptosis: biochemical and cytochemical aspects. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 146 (4), 443-459.
13. Furieri, L.B., Galán, M., Avendan{ogonek} o, M.S., García-Redondo, A.B., Aguado, A., Martínez, S., Cachofeiro, V., Bartolomé, M.V., Alonso, M.J., Vassallo, D.V., Salaices, M., 2011. Endothelial dysfunction of rat coronary arteries after exposure to low concentrations of mercury is dependent on reactive oxygen species. Br. J. Pharmacol. 162 (8), 1819-1831.
14. Gasparini, L., Racchi, M., Binetti, C., Trabucchi, M., Solerte, S.B., Alkon, D., Etcheberrigaray, R., Gibson, G., Paoletti, R., Govoni, S., 1998. Peripheral markers in testing pathophysiological hypothesis and diagnosing Alzheimer's disease. FASEB 12, 17-34.
15. Hissin, P.J., Hilf, R., 1976. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74, 214-226.
16. Isaji, Y., Okochi, M., Horio, F., Honda, H., 2009. Use of erythrocyte adhesion assay to predict the risk of diabetic complications. Biochem. Eng. J. 43, 178-184.
17. Iwasaki, Y., Yamato, H., Fukagawa, M., 2011. Treatment with pravastatin attenuates oxidative stress and protects osteoblast cell viability from indoxyl sulfate. Ther. Apher. Dial. 15 (2), 151-165.
18. Kassan, M., Montero, M.J., Sevilla, M.A., 2010. In vitro antioxidant activity of pravastatin provides vascular protection. Eur. J. Pharmacol. 630 (1-3), 107-111.
19. Kleinbongard, P., Schulz, R., Rassaf, T., Lauer, T., Dejam, A., Jax, T., Kumara, I., Gharini, P., Kabanova, S., Ozüyaman, B., Schnürch, H.G., Gödecke, A., Weber, A.A., Robenek, M., Robenek, H., Bloch, W., Rösen, P., Kelm, M., 2006. Red blood cells express a functional endothelial nitric oxide synthase. Blood 107 (7), 2943-2951.
20. Kraus, A., Roth, H.P., Kirchgessner, M., 1997. Supplementation with vitamin C, vitamin E or beta-carotene influences osmotic fragility and oxidative damage of erythrocytes of zinc-deficient rats. J. Nutr. 127 (7), 1290-1296.
21. Krukoski, D.W., Comar, S.R., Claro, L.M., Leonart, M.S., Nascimento, A.J., 2009. Effect of vitamin C, deferoxamine, quercetin and rutin against tert-butyl hydroperoxides oxidative damage in human erythrocytes. Hematology 14, 168-172.
22. LeBel, C.P., Bondy, S.C., 1991. Oxygen radicals: common mediators of neurotoxicity. Neurotoxicol. Teratol. 13, 341-346.
23. Levine, R.L., Williams, J.A., Stadtman, E.R., Shacter, E., 1994. Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol. 233, 346-357.
24. Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275, 1951.
25. Mandal, D., Moitra, P.K., Saha, S., Basu, J., 2002. Caspase-3 regulates phosphatidylserine externalization and phagocytosis of oxidatively stressed erythrocytes. FEBS Lett. 513, 184-188.
26. Marklund, S., Marklund, G., 1974. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47, 469-474.
27. McGown, C.C., Brown, N.J., Hellewell, P.G., Reilly, C.S., Brookes, Z.L., 2010. Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III. Br. J. Anaesth. 104 (2), 183-190.
28. Minetti, M., Agati, L., Malorni, W., 2007. The microenvironment can shift erythrocytes from a friendly to a harmful behavior: pathogenetic implications for vascular diseases. Cardiovasc. Res. 75 (1), 21-28.
29. Muniz-Junqueira, M.I., Karnib, S.R., de Paula-Coelho, V.N., Junqueira, L.F., 2006. Effects of pravastatin on the in vitro phagocytic function and hydrogen peroxide production by monocytes of healthy individuals. Internat. Immunopharmacol. 6, 53-60.
30. Obata, T., 2006. Protective effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on copper-induced hydroxyl radical generation in the rat heart. Toxicology 223 (3), 175-180.
31. Ohkawa, H., Ohishi, N., Yagi, K., 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351-358.
32. Okwusidi, J.I., 2004. Long term storage stabilizes human erythrocytes membrane in Nigerian black males. Afr. J. Biomed. Res. 7, 9-12.
33. Omanwar, S., Ravi, K., Fahim, M., 2010. Persistence of EDHF pathway and impairment of the nitric oxide pathway after chronic mercury chloride exposure in rats: mechanisms of endothelial dysfunction. Hum. Exp. Toxicol. 30 (11), 1777-1784.
34. Pandey, K.B., Mishra, N., Rizvi, S.I., 2009. Protective role of myricetin on markers of oxidative stress in human erythrocytes subjected to oxidative stress. Nat. Prod. Commun. 4, 221-226.
35. Patnaik, B.B., Roy, A., Agarwal, S., Bhattacharya, S., 2010. Induction of oxidative stress by non-lethal dose of mercury in rat liver: possible relationships between apoptosis and necrosis. J. Environ. Biol. 31 (4), 413-506.
36. Pawloski, J.R., Stamler, J.S., 2002. Nitric oxide in RBCs. Transfusion 42, 1603-1609.
37. Rao, M.V., Chhunchha, B., 2010. Protective role of melatonin against the mercury induced oxidative stress in the rat thyroid. Food Chem. Toxicol. 48 (1), 7-10.
38. Robaszkiewicz, A., Bartosz, G., Soszynski, M., 2008. N-chloroamino acids cause oxidative protein modifications in the erythrocyte membrane. Mech. Ageing Dev. 129, 572-579.
39. Rotruck, J.T., Rope, A.L., Ganther, H.F., Swason, A.B., 1973. Selenium: biochemical role as a component of glutathione peroxidase. Science 179, 588-590.
40. Salonen, J.T., Seppanen, K., Nyyssonen, K., 1995. Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men. Circulation 91, 645-655.
41. Saravanakumar, M., Raja, B., 2011. Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in l-NAME induced hypertensive rats. Eur. J. Pharmacol. 671 (1-3), 87-94.
42. Schulz, R., Rassaf, T., Massion, P.B., Kelm, M., Balligand, J.L., 2005. Recent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis. Pharmacol. Ther. 108, 225-256.
43. Sener, G., Sehirli, O., Tozan, A., Velio ̌ glu-Ovunç, A., Gedik, N., Omurtag, G.Z., 2007. Ginkgo biloba extract protects against mercury(II)-induced oxidative tissue damage in rats. Food Chem. Toxicol. 45 (4), 543-550.
44. Shuto, H., Tominaga, K., Yamauchi, A., Ikeda, M., Kusaba, K., Mitsunaga, D., Hirabara, Y., Egawa, T., Takano, Y., Kataoka, Y., 2011. The statins fluvastatin and pravastatin exert anti-flushing effects by improving vasomotor dysfunction through nitric oxide-mediated mechanisms in ovariectomized animals. Eur. J. Pharmacol. 651 (1-3), 234-239.
45. Stohs, S.J., Bagchi, D., 1995. Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med. 18, 321-336.
46. Virtanen, J.K., Rissanen, T.H., Voutilainen, S., Tuomainen, T.P., 2007. Mercury as a risk factor for cardiovascular diseases. J. Nutr. Biochem. 18 (2), 75-85.