Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4719-4722

  Chaturvedula, Prasad V ^a   Pin, Sokhom ^a   Tholady, George ^a   Conway, Charlie M ^a   MacOr, John E ^a   Dubowchik, Gene M ^a  

^a BRISTOL MYERS SQUIBB RESEARCH AND DEVELOPMENT   (United States)

Author keywords

CGRP receptor antagonists

Indexed keywords

ANTIMIGRAINE AGENT; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; SPIROPIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BRAIN ARTERY; CARBOXY TERMINAL SEQUENCE; DRUG DESIGN; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; EX VIVO STUDY; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; MIGRAINE; OXIDATIVE STRESS; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; VASODILATATION;

DRUG DESIGN; HYDROGEN BONDING; MOLECULAR STRUCTURE; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863452560     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.118     Document Type: Article

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