Spiro-substituted piperidines as neurokinin receptor antagonists. II. Syntheses and NK2 receptor-antagonistic activities of N-[2-aryl-4-(spiro- substituted piperidin-1'-yl)butyl]carboxamides

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 2, 1998, Pages 242-254

  Kubota, Hirokazu ^a   Kakefuda, Akio ^a   Nagaoka, Hitoshi ^a   Yamamoto, Osamu ^a   Ikeda, Ken ^a   Takeuchi, Makoto ^a   Shibanuma, Tadao ^a   Isomura, Yasuo ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Neurokinin A; NK1 NK2 dual antagonist; NK2 receptor antagonist; Spiro substituted piperidine; YM 38336; YM 35375

Indexed keywords

1' [4 (N BENZOYL N METHYLAMINO) 3 (3,4 DICHLOROPHENYL)BUTYL]SPIRO[BENZO[C]THIOPHENE 1(3H) 4' PIPERIDINE] 2 OXIDE; N [2 (3,4 DICHLOROPHENYL) 4 (SPIRO[ISOBENZOFURAN 1(3H) 4' PIPERIDIN] 1' YL)BUTYL] N METHYLBENZAMIDE; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ A; PIPERIDINE DERIVATIVE; TACHYKININ RECEPTOR; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRONCHOSPASM; DRUG RECEPTOR BINDING; GUINEA PIG; NONHUMAN; RECEPTOR BLOCKING; SMOOTH MUSCLE CONTRACTION;

EID: 0031917153     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.242     Document Type: Article

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