Relationship of low-circulating "anti-Aging" klotho hormone with disability in activities of daily living among older community-dwelling adults

Rejuvenation Research

Volumn 15, Issue 3, 2012, Pages 295-301

  Crasto, Candace L ^a   Semba, Richard D ^a   Sun, Kai ^a   Cappola, Anne R ^b   Bandinelli, Stefania ^c   Ferrucci, Luigi ^d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Azienda Sanitaria   (Italy)

^d NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KLOTHO PROTEIN; MEMBRANE PROTEIN;

ADL DISABILITY; AGED; AGING; AGING SUPPRESSOR GENE; ARTICLE; BLOOD SAMPLING; COHORT ANALYSIS; COMMUNITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE; HORMONE BLOOD LEVEL; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; PLASMA; PRIORITY JOURNAL;

ACTIVITIES OF DAILY LIVING; ADULT; AGED; AGED, 80 AND OVER; AGING; ANIMALS; DISABLED PERSONS; FEMALE; GLUCURONIDASE; HUMANS; LOGISTIC MODELS; MALE; MICE; MULTIVARIATE ANALYSIS; RESIDENCE CHARACTERISTICS;

MUS; NICOTIANA TABACUM;

EID: 84863451112     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2011.1268     Document Type: Article

References (35)

1. Sullivan MD, Kempen GI, van Sonderen E, Ormel J. Models of health-related quality of life in a population of community-dwelling Dutch elderly. Qual Life Res 2000;9:801-810. (Pubitemid 32209794)
2. Manton KG. Recent declines in chronic disability in the elderly U.S. population: Risk factors and future dynamics. Annu Rev Public Health 2008;29:91-113. (Pubitemid 351600401)
3. Guralnik JM, Alecxih L, Branch LG, Wiener JM. Medical and long-term care costs when older persons become more dependent. Am J Public Health 2002;92:1244-1245. (Pubitemid 34815783)
4. Stuck AE, Walthert JM, Nikolaus T, Bü la CJ, Hohmann C, Beck JC. Risk factors for functional status decline in community-living elderly people: A systematic literature review. Soc Sci Med 1999;48:445-469. (Pubitemid 29023277)
5. Huang WNW, Perera S, VanSwearingen J, Studenski S. Performance measures predict onset of activity of daily living difficulty in community-dwelling older adults. J Am Geriatr Soc 2010;58:844-852.
6. Cawthon PG, Fox KM, Gandra SR, Delmonico MJ, Choiu CF, Anthony MS, Caserotti P, Kritchevsky SB, Newman AB, Goodpaster BH, Satterfield S, Cummings SR, Harris TB, Health Aging and Body Composition Study. Clustering of strength, physical function, muscle, and adiposity characteristics and risk of disability in older adults. J Am Geriatr Soc 2011;59:781-787.
7. Schultz-Larsen K, Rahmanfard N, Holst C. Physical activity (PA) and the disablement process: a 14-year follow-up study of older non-disabled women and men. Arch Gerontol Geriatr 2011 [Epub ahead of print].
8. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima Y. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997;390:45-51. (Pubitemid 27494749)
9. Iida R, Kanko S, Suga T, Morito M, Yamane A. Autophagiclysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging. Mol Cell Biochem 2011;348:89-98.
10. Kuro-o M. Klotho. Eur J Physiol 2010;459:333-343.
11. Saito Y, Yamagishi T, Nakamura T, Ohyama Y, Aizawa H, Suga T, Matsumura Y, Masuda H, Kurabayashi M, Kuro-o M, Nabeshima Y, Nagai R. Klotho protein protects against endothelial dysfunction. Biochem Biophys Res Comm 1998;248:324-329. (Pubitemid 28386420)
12. Saito Y, Nakamura T, Ohyama Y, Suzuki T, Iida A, Shiraki-Iida T, Kuro-o M, Nabeshima Y, Kurabayashi M, Nagai R. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochem Biophys Res Comm 2000;276:767-772.
13. Wang Y, Sun Z. Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage. Hypertension 2009;54:810-817.
14. Kurosu H, Yamamoto M, Clark JE, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M. Suppression of aging in mice by the hormone klotho. Science 2005;308:1829-1833. (Pubitemid 41325087)
15. Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, Baum MG, Schiavi S, Hu MC, Moe OW, Kuro-o M. Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 2006; 281:6120-6123. (Pubitemid 43847540)
16. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006;444:770-774. (Pubitemid 44949607)
17. Nabeshima YI, Imura H. Alpha-klotho: A regulator that integrates calcium homeostasis. Am J Nephrol 2008;28:455-464. (Pubitemid 351501612)
18. Yamazaki Y, Imura A, Urakawa I, Shimada T, Murakami J, Aono Y, Hasegawa H, Yamashita T, Nakatani K, Saito Y, Okamoto N, Kurumatani N, Namba N, Kitaoka T, Ozono K, Sakai T, Hataya H, Ichikawa S, Imel EA, Econs MJ, Nabeshima YI. Establishment of a sandwich ELISA for soluble alpha-klotho measurements: Age-dependent change of soluble alpha-klotho levels in healthy subjects. Biochem Biophys Res Commun 2010;398:513-518.
19. Semba RD, Cappola AR, Sun K, Bandinelli S, Dalal M, Crasto C, Guralnik JM, Ferrucci L. Relationship of low plasma klotho with poor grip strength in older communitydwelling adults: The InCHIANTI Study. Eur J Appl Physiol 2011; July 7 [Epub ahead of print] DOI: 10.1007/s00421-011-2072-3.
20. Semba RD, Cappola AR, Sun K, Bandinelli S, Dalal M, Crasto C, Guralnik JM, Ferrucci L. Plasma klotho and mortality risk in older community-dwelling adults. J Gerontol A Biol Sci Med Sci 2011;66:794-800.
21. Ferrucci L, Bandinelli S, Benvenuti E, Di Iorio A, Macchi C, Harris TB, Guralnik JM. Subsystems contributing to the decline in ability to walk: Bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. J Am Geriatr Soc 2000;48:1618-1625.
22. Guralnik JM, Fried LP, Simonsick EM, Kasper JD. The Women's Health and Aging Study: Health and Social Characteristics of Older Women with Disability. National Institute on Aging, Bethesda, MD, NIH Publication No. 95-4009, 1995.
23. Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State" A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
24. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Ann Intern Med 1999;130:461-470. (Pubitemid 29135798)
25. Milaneschi Y, Bandinelli S, Corsi AM, Lauretani F, Paolisso G, Dominguez LJ, Semba RD, Tanaka T, Abbatecola AM, Talegawkar SA, Guralnik JM, Ferrucci L. Mediterranean diet and mobility decline in older persons. Exp Gerontol 2011;46:303-308.
26. Balzi D, Lauretani F, Barchielli A, Ferrucci L, Bandinelli S, Buiatti E, Milaneschi Y, Guralnik JM. Risk factors for disability in older persons over 3-year follow-up. Age Ageing 2010;39:92-98.
27. Iida R, Kanko S, Suga T, Morito M, Yamane A. Autophagiclysosomal pathway functions in the masseter and tongue muscle in the klotho mouse, a mouse model for aging. Mol Cell Biochem 2011;348:89-98.
28. Yamamoto M, Clark JD, Pastor JV, Gurnani P, Nandi A, Kurosu H, Miyoshi M, Ogawa Y, Castrillon DH, Rosenblatt KP, Kuro-o M. Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem 2005;280:38029-38034. (Pubitemid 41642417)
29. Arking DE, Atzmon G, Arking A, Barzilai N, Dietz HC. Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ Res 2005;96:412-418. (Pubitemid 40354534)
30. Majumdar V, Nagaraja D, Christopher R. Association of the functional KL-KS variant of klotho gene with early-onset inschemic stroke. Biochem Biophys Res Commun 2010;403: 412-416.
31. Shimoyama Y, Nishio K, Hamajima N, Niwa T. KLOTHO gene polymorphisms G-395A and C1818T are associated with lipid and glucose metabolism, bone mineral density and systolic blood pressure in Japanese healthy subjects. Clin Chim Acta 2009;406:134-138.
32. Zarrabeitia MT, Hernández JL, Valero C, Zarrabeitia AL, Ortiz F, Gonzalez-Macias J, Riancho JA. Klotho gene polymorphism and male bone mass. Calcif Tissue Int 2007;80:10-14. (Pubitemid 46095745)
33. Riancho JA, Valero C, Hernández JL, Ortiz F, Zarrabeitia A, Alonso MA, Pena N, Pascual MA, Conzalez-Macias J, Zarra-beita MT. Association of the F352V variant of the Klotho gene with bone mineral density. Biogerontology 2007;8:121-127. (Pubitemid 46487981)
34. Uchida A, Komiya T, Tashiro T, Yorifuji H, Kishimoto T, Nabeshima Y, Hisanaga S. Neurofilaments of klotho, the mutant mouse prematurely displaying symptoms resembling human aging. J Neurosci Res 2001;64:363-370.
35. Shiozaki M, Yoshimura K, Shibata M, Koike M, Matsuura N, Uchiyama Y, Gotow T. Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice. Neuroscience 2008;152:924-941.