Design, synthesis and biological evaluation of β-carboline derivatives as novel inhibitors targeting B-Raf kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4783-4786

  Xin, Botao ^a   Tang, Weifang ^a   Wang, Yue ^a   Lin, Guowu ^a   Liu, Haichun ^a   Jiao, Yu ^a   Zhu, Yong ^a   Yuan, Haoliang ^a   Chen, Yadong ^a   Lu, Tao ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Carboline derivatives; B Raf kinase inhibitor; Kinase inhibitory activities

Indexed keywords

1 CARBOXAMIDE 6 [N [3 (DIMETHYLAMINO)PROPYL]SULFAMOYL]BETA CARBOLINE; ALKALOID DERIVATIVE; B RAF KINASE; B RAF KINASE INHIBITOR; BETA CARBOLINE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; WILD TYPE;

CARBOLINES; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863450452     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.053     Document Type: Article

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