Monitoring peripheral blood CD4+ intracellular adenosine triphosphate concentration in patients with psoriasis treated with fumaric acid esters

Acta Dermato-Venereologica

Volumn 92, Issue 4, 2012, Pages 364-366

  Gambichler, Thilo ^a   Scola, Nina ^a   Rotterdam, Sebastian ^a   Höxtermann, Stephan ^a   Haghikia, Aiden ^a   Faissner, Simon ^a   Kreuter, Alexander ^a   Bechara, Falk G ^a   Altmeyer, Peter ^a   Chan, Andrew ^a  

^a ST JOSEF HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; FUMADERM; FUMARIC ACID DIMETHYL ESTER; FUMARIC ACID ETHYL ESTER;

ADULT; AGED; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CYTOKINE RELEASE; FEMALE; HUMAN; INFECTION; INTRACELLULAR SIGNALING; LETTER; MALE; OPPORTUNISTIC INFECTION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PSORIASIS VULGARIS; T LYMPHOCYTE ACTIVATION;

ADENOSINE TRIPHOSPHATE; ADULT; AGED; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; FUMARATES; GERMANY; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; PILOT PROJECTS; PSORIASIS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84863437123     PISSN: 00015555     EISSN: None     Source Type: Journal    
DOI: 10.2340/00015555-1266     Document Type: Letter

References (15)

1. Mrowietz U, Christophers E, Altmeyer P. Treatment of severe psoriasis with fumaric acid esters: scientific back-ground and guidelines for therapeutic use. The German Fumaric Acid Ester Consensus Conference. Br J Dermatol 1999; 141: 424-429.
2. ®: Fumarsäureester für die systemische Behandlung der mittelschweren und schweren Psoriasis vulgaris. J Dtsch Dermatol Ges 2009; 7 Suppl 2: 3-16.
3. Höxtermann S, Nüchel C, Altmeyer P. Fumaric acid esters suppress peripheral CD4- and CD8-positive lymphocytes in psoriasis. Dermatology 1998; 196: 223-230.
4. Lehmann JC, Listopad JJ, Rentzsch CU, Igney FH, von Bonin A, Hennekes HH, et al. Dimethylfumarate induces immunosuppression via glutathione depletion and subse- quent induction of heme oxygenase 1. J Invest Dermatol 2007; 127: 835-845.
5. Moed H, Stoof TJ, Boorsma DM, von Blomberg BM, Gibbs S, Bruynzeel DP, et al. Identification of anti-inflammatory drugs according to their capacity to suppress type-1 and type-2 T cell profiles. Clin Exp Allergy 2004; 34: 1868-1875.
6. Bovenschen HJ, Langewouters AM, van de Kerkhof PC. Dimethylfumarate for psoriasis: Pronounced effects on lesional T-cell subsets, epidermal proliferation and differen- tiation, but not on natural killer T cells in immunohistoche- mical study. Am J Clin Dermatol 2010; 11: 343-350.
7. Reich K, Thaci D, Mrowietz U, Kamps A, Neureither M, Luger T. Efficacy and safety of fumaric acid esters in the long-term treatment of psoriasis - a retrospective study (FUTURE). J Dtsch Dermatol Ges 2009; 7: 603-611.
8. Kowalski RJ, Zeevi A, Mannon RB, Britz JA, Carruth LM. Immunodiagnostics: evaluation of functional T-cell immu- nocompetence in whole blood independent of circulating cell numbers. J Immunotoxicol 2007; 4: 225-232.
9. Nickel P, Bestard O, Volk HD, Reinke P. Diagnostic value of T-cell monitoring assays in kidney transplantation. Curr Opin Organ Transplant 2009; 14: 426-431.
10. Haghikia A, Perrech M, Pula B, Ruhrmann S, Potthoff A, Brockmeyer NH, et al. Functional energetics of CD4+cellular immunity in monoclonal antibody-associated progressive multifocal leukoencephalopathy in autoimmune disorders. PlosOne 2011; 6: e18506.
11. Gambichler T, Tigges C, Burkert B, Höxtermann S, Altmeyer P, Kreuter A. Absolute count of T and B lymphocyte subsets is decreased in systemic sclerosis. Eur J Med Res 2010; 15: 44-46.
12. Rostami-Yazdi M, Clement B, Mrowietz U. Pharmacokine- tics of anti-psoriatic fumaric acid esters in psoriasis patients. Arch Dermatol Res 2010; 302: 531-538.
13. Litjens NHR, Burggraaf J, van Strijen E, van Gulpen C, Mattie H, Schoemaker RC, et al. Pharmacokinetics of oral fumarates in healthy subjects. Brit J Clin Pharmacol 2004; 58: 429-432.
14. Zhu K, Mrowietz U. Enhancement of antibacterial superox- ide-anion generation in human monocytes by fumaric acid esters. Arch Dermatol Res 2005; 297: 170-176.
15. Kowalski R, Post D, Schneider MC, Britz J, Thomas J, Deierhoi M, et al. Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient mana- gement. Clin Transplant 2003; 17: 77-88.