Pharmacokinetics of anti-psoriatic fumaric acid esters in psoriasis patients

Archives of Dermatological Research

Volumn 302, Issue 7, 2010, Pages 531-538

  Rostami Yazdi, Martin ^a,b   Clement, Bernd ^b   Mrowietz, Ulrich ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

Anti inflammatory drugs; Dimethylfumarate; Fumaric acid esters; Monomethylfumarate; Multiple sclerosis; Psoriasis

Indexed keywords

FUMADERM; FUMARIC ACID;

ADULT; AREA UNDER THE CURVE; ARTICLE; CASE REPORT; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG UPTAKE; HUMAN; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PSORIASIS; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADULT; DUODENUM; FUMARATES; HALF-LIFE; HUMANS; HYDROLYSIS; MALE; MALEATES; MIDDLE AGED; PSORIASIS;

EID: 77955556405     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-010-1061-4     Document Type: Article

References (26)

1. PJ Altmeyer U Matthes F Pawlak K Hoffmann PJ Frosch P Ruppert SW Wassilew T Horn HW Kreysel G Lutz 1994 Antipsoriatic effect of fumaric acid derivatives. Results of a multicenter double-blind study in 100 patients J Am Acad Dermatol 30 977 981 10.1016/S0190-9622(94)70121-0 1:STN:280:DyaK2c3ksF2rsA%3D%3D 8188891
2. M Bartolini C Bertucci R Gotti V Tumiatti A Cavalli M Recanatini V Andrisano 2002 Determination of the dissociation constants (pKa) of basic acetylcholinesterase inhibitors by reversed-phase liquid chromatography J Chromatogr A 958 59 67 10.1016/S0021-9673(02)00385-0 1:CAS:528: DC%2BD38XktVChsLg%3D 12134831 (Pubitemid 34563237)
3. L Brewer S Rogers 2007 Fumaric acid esters in the management of severe psoriasis Clin Exp Dermatol 32 246 249 10.1111/j.1365-2230.2007.02389.x 1:STN:280:DC%2BD2s7psF2htQ%3D%3D 17362235 (Pubitemid 46495809)
4. J Fallingborg LA Christensen M Ingeman-Nielsen BA Jacobsen K Abildgaard HH Rasmussen 1989 pH-profile and regional transit times of the normal gut measured by a radiotelemetry device Aliment Pharmacol Ther 3 605 613 10.1111/j.1365-2036.1989.tb00254.x 1:STN:280:DyaK38%2Fgt1Kntg%3D%3D 2518873
5. Fumapharm/Biogen Idec 2005 BG 12/Oral Fumarate, FAG-201, second-generation fumarate derivative-Fumapharm/Biogen Idec Drugs R D 6 229 230 10.2165/00126839-200506040-00005 (Pubitemid 40994244)
6. S Gerdes K Shakery U Mrowietz 2007 Dimethylfumarate inhibits nuclear binding of nuclear factor kappaB but not of nuclear factor of activated T cells and CCAAT/enhancer binding protein beta in activated human T cells Br J Dermatol 156 838 842 10.1111/j.1365-2133.2007.07779.x 1:CAS:528:DC%2BD2sXmt12rsbk%3D 17381463 (Pubitemid 46642827)
7. JJ Hoefnagel HB Thio R Willemze JN Bouwes Bavinck 2003 Long-term safety aspects of systemic therapy with fumaric acid esters in severe psoriasis Br J Dermatol 149 363 369 10.1046/j.1365-2133.2003.05433.x 1:CAS:528: DC%2BD3sXnvVKrsrY%3D 12932244 (Pubitemid 37100263)
8. DN Kolbach C Nieboer 1992 Fumaric acid therapy in psoriasis: results and side effects of 2 years of treatment J Am Acad Dermatol 27 769 771 10.1016/S0190-9622(08)80228-9 1:STN:280:DyaK3s%2FlsFKrsw%3D%3D 1430403
9. JC Lehmann JJ Listopad CU Rentzsch FH Igney A von Bonin HH Hennekes K Asadullah WD Docke 2007 Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1 J Invest Dermatol 127 835 845 10.1038/sj.jid.5700686 1:CAS:528:DC%2BD2sXivVGlsbs%3D 17235328 (Pubitemid 46434667)
10. CA Lipinski F Lombardo BW Dominy PJ Feeney 2001 Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv Drug Deliv Rev 46 3 26 10.1016/S0169-409X(00)00129-0 1:CAS:528:DC%2BD3MXitVOhs7o%3D 11259830 (Pubitemid 33653411)
11. NH Litjens J Burggraaf E van Strijen C van Gulpen H Mattie RC Schoemaker JT van Dissel HB Thio PH Nibbering 2004 Pharmacokinetics of oral fumarates in healthy subjects Br J Clin Pharmacol 58 429 432 10.1111/j.1365-2125.2004.02145.x 1:CAS:528:DC%2BD2cXpsVShs7c%3D 15373936 (Pubitemid 39312467)
12. NH Litjens E van Strijen C van Gulpen H Mattie JT van Dissel HB Thio PH Nibbering 2004 In vitro pharmacokinetics of anti-psoriatic fumaric acid esters BMC Pharmacol 4 22 10.1186/1471-2210-4-22 15479475 (Pubitemid 40177092)
13. U Mrowietz E Christophers P Altmeyer 1998 Treatment of psoriasis with fumaric acid esters: results of a prospective multicentre study Br J Dermatol 138 456 460 10.1046/j.1365-2133.1998.02124.x 1:CAS:528:DyaK1cXisVWru70%3D 9580799 (Pubitemid 28145514)
14. U Mrowietz E Christophers P Altmeyer 1999 Treatment of severe psoriasis with fumaric acid esters: scientific background and guidelines for therapeutic use. The German fumaric acid ester consensus conference Br J Dermatol 141 424 429 10.1046/j.1365-2133.1999.03034.x 1:STN:280:DC%2BD3c%2FltVWhtQ%3D%3D 10584060 (Pubitemid 29448401)
15. A Nast IB Kopp M Augustin KB Banditt WH Boehncke M Follmann M Friedrich M Huber C Kahl J Klaus J Koza I Kreiselmaier J Mohr U Mrowietz HM Ockenfels HD Orzechowski J Prinz K Reich T Rosenbach S Rosumeck M Schlaeger G Schmid-Ott M Sebastian V Streit T Weberschock B Rzany 2006 S3-Guidelines for the therapy of psoriasis vulgaris J Dtsch Dermatol Ges 4 Suppl 2 S1 S126 17187649
16. C Nieboer D de Hoop PN Langendijk AC van Loenen J Gubbels 1990 Fumaric acid therapy in psoriasis: a double-blind comparison between fumaric acid compound therapy and monotherapy with dimethylfumaric acid ester Dermatologica 181 33 37 10.1159/000247856 1:STN:280:DyaK3czmslymtQ%3D%3D 2394301
17. M Rostami-Yazdi B Clement TJ Schmidt D Schinor U Mrowietz 2009 Detection of metabolites of fumaric acid esters in human urine: implications for their mode of action J Invest Dermatol 129 231 234 10.1038/jid.2008.197 1:CAS:528:DC%2BD1cXhsVymu7%2FI 18704112
18. S Schilling S Goelz R Linker F Luehder R Gold 2006 Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration Clin Exp Immunol 145 101 107 10.1111/j.1365-2249.2006. 03094.x 1:CAS:528:DC%2BD28XpsFGrurw%3D 16792679 (Pubitemid 43893938)
19. S Schimrigk N Brune K Hellwig C Lukas B Bellenberg M Rieks V Hoffmann D Pohlau H Przuntek 2006 Oral fumaric acid esters for the treatment of active multiple sclerosis: an open-label, baseline-controlled pilot study Eur J Neurol 13 604 610 10.1111/j.1468-1331.2006.01292.x 1:STN:280:DC%2BD28zotFagsw%3D%3D 16796584 (Pubitemid 43873632)
20. W Schweckendiek 1959 Behandlung der Psoriasis Med Monatsschr 13 103 104 1:STN:280:DyaG1M%2Fntlaktg%3D%3D 13643669
21. TJ Stoof J Flier S Sampat C Nieboer CP Tensen DM Boorsma 2001 The antipsoriatic drug dimethylfumarate strongly suppresses chemokine production in human keratinocytes and peripheral blood mononuclear cells Br J Dermatol 144 1114 1120 10.1046/j.1365-2133.2001.04220.x 1:CAS:528:DC%2BD3MXltFeiu70%3D 11422029 (Pubitemid 34204199)
22. B Thio JG van der Schroeff WM Nugteren-Huying BJ Vermeer 1995 Long term systemic therapy with dimethylfumarate and monoethylfumarate (Fumaderm) in psoriasis J Eur Acad Dermatol Venereol 4 35 40 10.1016/0926-9959(94)00056-6 (Ref type: Generic)
23. F Treumer K Zhu R Gläser U Mrowietz 2003 Dimethylfumarate is a potent inducer of apoptosis in human T cells J Invest Dermatol 121 1383 1388 10.1111/j.1523-1747.2003.12605.x 1:CAS:528:DC%2BD2cXhtVaksA%3D%3D 14675187 (Pubitemid 38005490)
24. DF Veber SR Johnson HY Cheng BR Smith KW Ward KD Kopple 2002 Molecular properties that influence the oral bioavailability of drug candidates J Med Chem 45 2615 2623 10.1021/jm020017n 1:CAS:528:DC%2BD38XjsFCmt7g%3D 12036371 (Pubitemid 34595232)
25. D Werdenberg R Joshi S Wolffram HP Merkle P Langguth 2003 Presystemic metabolism and intestinal absorption of antipsoriatic fumaric acid esters Biopharm Drug Dispos 24 259 273 10.1002/bdd.364 1:CAS:528:DC%2BD3sXnsFynt7w%3D 12973823 (Pubitemid 37160613)
26. K Zhu U Mrowietz 2001 Inhibition of dendritic cell differentiation by fumaric acid esters J Invest Dermatol 116 203 208 10.1046/j.1523-1747.2001. 01159.x 1:CAS:528:DC%2BD3MXhsVKisbs%3D 11179994 (Pubitemid 32173722)