Animal Models: Genetic Manipulation

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Seventh Edition

Volumn , Issue , 2009, Pages 45-51

  Lyons, Karen ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Embryonic stem cells; Gene targeting; Knockout; Transgenic

Indexed keywords

EID: 84863399069     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470623992.ch8     Document Type: Chapter

References (54)

1. Horiki M, Imamura T, Okamoto M, Hayashi M, Murai J, Myoui A, Ochi T, Miyazono K, Yoshikawa H, Tsumaki N.2004. Smad6/Smurfl overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia. J Cell Biol, 165:433-45.
2. Li SW, Arita M, Kopen GC, Phinney DG, Prockop DJ.1998. A 1,064 bp fragment from the promoter region of the Collla2 gene drives lacZ expression not only in cartilage but also in osteoblasts adjacent to regions undergoing both endochondral and intramem-branous ossification in mouse embryos. Matrix Biol, 17:213-221.
3. Martin JF, Olson EN.2000. Identification of a prxl limb enhancer. Genesis, 26:225-229.
4. Campbell MR, Gress CJ, Appleman EH, Jacenko O.2004. Chicken collagen X regulatory sequences restrict transgene expression to hypertrophic cartilage in mice. Am J Pathol, 164:487-199.
5. Gebhard S, Hattori T, Bauer E, Bosl MR, Schlund B, Poschl E, Adam N, de Crombrugghe B, von der Mark K.2007. BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete CollOal promoter. Histochem Cell Biol, 127:183-194.
6. Liu F, Woitge HW, Braut A, Kronenberg MS, Lichtler AC, Mina M, Kream BE.2004. Expression and activity of osteoblast-targeted Cre recombinase transgenes in murine skeletal tissues. Int J Dev Biol, 48:645-653.
7. Dacquin R, Starbuck M, Schinke T, Karsenty G.2002. Mouse alphal(l)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblasts. Dev Dyn, 224:245-251.
8. Zhang M, Xuan S, Bouxsein ML, von Stechow D, Akeno N, Faugere MC, Malluche H, Zhao G, Rosen CJ, Efstratiadis A, Clemens TL 2002 Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem 277:44005-44012.
9. Lu Y, Xie Y, Zhang S, Dusevich V, Bonewald LF, Feng JQ.2007. DMP1-targeted Cre expression in odontoblasts and osteocytes. J Dent Res, 86:320-325.
10. Pryce BA, Brent AE, Murchison ND, Tabin CJ, Schweitzer R.2007. Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene. Dev Dyn, 236:1677-1682.
11. Ferron M, Vacher J.2005. Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice. Genesis, 41:138-145.
12. Reddy SV, Hundley JE, Windle J J, Alcantara O, Linn R, Leach RJ, Boldt DH, Roodman GD.1995. Characterization of the mouse tartrate-resistant acid phosphatase (TRAP) gene promoter. J Bone Miner Res, 10:601-606.
13. Branda CS, Dymecki SM.2004. Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. Dev Cell, 6:7-28.
14. Ornitz DM, Moreadith RW, Leder P.1991. Binary system for regulating transgene expression in mice: Targeting int-2 gene expression with yeast GAL4/UAS control elements. Proc Natl Acad Sci USA, 88:698-702.
15. Liu Z, Shi W, Ji X, Sun C, Jee WS, Wu Y, Mao Z, Nagy TR, Li Q, Cao X.2004. Molecules mimicking Smadl interacting with Hox stimulate bone formation. J Biol Chem, 279:11313-11319.
16. Kobayashi T, Lyons KM, McMahon AP, Kronenberg HM.2005. BMP signaling stimulates cellular differentiation at multiple steps during cartilage development. Proc Natl Acad Sci USA, 102:18023-18027.
17. McVicar DW, Winkler-Pickett R, Taylor LS, Makrigiannis A, Bennett M, Anderson SK, Ortaldo JR.2002. Aberrant DAP12 signaling in the 129 strain of mice: Implications for the analysis of gene-targeted mice. J Immunol, 169:1721-1728.
18. Keskintepe L, Norris K, Pacholczyk G, Dederscheck SM, Eroglu A.2007. Derivation and comparison of C57BL/6 embryonic stem cells to a widely used 129 embryonic stem cell line. Transgenic Res, 16:751-758.
19. Rosen CJ, Beamer WG, Donahue LR.2001. Defining the genetics of osteoporosis: Using the mouse to understand man. Osteoporos Int, 12:803-810.
20. Poueymirou WT, Auerbach W, Frendewey D, Hickey JF, Escara-vage JM, Esau L, Dore AT, Stevens S, Adams NC, Dominguez MG, Gale NW, Yancopoulos GD, DeChiara TM, Valenzuela DM.2007. F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses. Nat Bio-technol, 25:91-99.
21. Feil R, Brocard J, Mascrez B, LeMeur M, Metzger D. Chambon P.1996. Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci USA, 93:10887-10890.
22. Logan M, Martin JF, Nagy A, Lobe C, Olson EN, Tabin CJ.2002. Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis, 33:77-80.
23. Yu K, Xu J, Liu Z, Sosie D, Shao J, Olson EN, Towler DA, Ornitz DM.2003. Conditional inaetivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development, 130:3063-3074.
24. Akiyama H, Chaboissier MC, Martin JF, Schedl A, de Crombrugghe B 2002 The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev 16:2813-2828.
25. Akiyama H, Kim JE, Nakashima K, Balmes G, Iwai N, Deng JM, Zhang Z, Martin JF, Behringer RR, Nakamura T, de Crombrugghe B.2005. Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci USA, 102:14665-14670.
26. Chai Y, Jiang X, Ito Y, Bringas P Jr, Han J, Rowitch DH, Soriano P. McMahon AP, Sucov H.2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development, 127:1671-1679.
27. Ovchinnikov DA, Deng JM, Ogunrinu G, Behringer RR.2000. Col2al-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice. Genesis, 26:145-146.
28. Nakamura E, Nguyen MT, Mackem S.2006. Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton. Dev Dyn, 235:2603-2612.
29. Grover J, Roughley PJ.2006. Generation of a transgenic mouse in which Cre recombinase is expressed under control of the type II collagen promoter and doxycycline administration. Matrix Biol, 25:158-165.
30. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B.2002. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell, 108:17-29.
31. Rodda SJ, McMahon AP.2006. Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development, 133:3231-3244.
32. Kim JE, Nakashima K, de Crombrugghe B.2004. Transgenic mice expressing a ligand-inducible cre recombinase in osteoblasts and odontoblasts: A new tool to examine physiology and disease of postnatal bone and tooth. Am J Pathol, 165:1875-1882.
33. Clausen BE, Burkhardt C, Reith W, Renkawitz R, Forster I.1999. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res, 8:265-277.
34. Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K. Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Tak-eda S. Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S.2007. Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell, 130:811-823.
35. Chiu WS, McManus JF, Notini AJ, Cassady AI, Zajac JD, Davey RA.2004. Transgenic mice that express Cre recombinase in osteoclasts. Genesis, 39:178-185.
36. Meyers EN, Lewandoski M, Martin GR.1998. An Fgf8 mutant allelic series generated by Cre-and Flp-mediated recombination. Nat Genet, 18:136-141.
37. Brown D, Wagner D, Li X, Richardson J A, Olson EN.1999. Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryo-genesis. Development, 126:4317-1329.
38. Murchison ND, Price BA, Conner DA, Keene DR, Olson EN, Tabin CJ, Schweitzer R.2007. Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development, 134:2697-2708.
39. Huang WY, Aramburu J, Douglas PS, Izumo S.2000. Transgenic expression of green fluorescence protein can cause dilated cardiomyopathy. Nat Med, 6:482-483.
40. Ryan ME, Greenwald RA, Golub LM.1996. Potential of tetracyclines to modify cartilage breakdown in osteoarthritis. Curr Opin Rheumatol, 8:238-247.
41. Bettany JT, Peet NM. Wolowacz RG, Skerry TM, Grabowski PS.2000. Tetracyclines induce apoptosis in osteoclasts. Bone, 27:75-80.
42. Starnes LM, Downey CM, Boyd SK, Jirik FR.2007. Increased bone mass in male and female mice following tamoxifen administration. Genesis, 45:229-235.
43. Soriano P.1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet, 21:70-71.
44. Jiang X, Iseki S, Maxson RE, Sucov HM, Morriss-Kay GM.2002. Tissue origins and interactions in the mammalian skull vault. Dev Biol, 241:106-116.
45. Lobe CG, Koop KE, Kreppner W, Lomeli H, Gertsenstein M, Nagy A.1999. Z/AP, a double reporter for cre-mediated recombination. Dev Biol, 208:281-292.
46. Cheon SS, Cheah AY, Turley S, Nadesan P, Poon R, Clevers H, Alman BA.2002. beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci USA, 99:6973-6978.
47. Chen Y, Whetstone HC, Lin AC, Nadesan P, Wei Q, Poon R, Alman BA 2007 Beta-catenin signaling plays a disparate role in different phases of fracture repair: Implications for therapy to improve bone healing. PLoS Med 4:e249.
48. Day TF, Guo X, Garrett-Beal L, Yang Y.2005. Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell, 8:739-750.
49. Monteiro RM, de Sousa Lopes SM, Korchynskyi O, ten Dijke P,Mummery CL.2004. Spatio-temporal activation of Smadl and Smad5 in vivo: Monitoring transcriptional activity of Smad proteins. J Cell Sci, 117:4653-4663.
50. D. Stanford WL, Epp T, Reid T, Rossant J.2006. Gene trapping in embryonic stem cells. Methods Enzymol, 420:136-162.
51. Consortium IMK.2007. A mouse for all reasons. Cell, 128:9-13.
52. Nagy TR, Krzywanski D, Li J, Meleth S, Desmond R.2002. Effect of group vs. single housing on phenotypic variance in C57BL/6J mice. Obes Res, 10:412-415.
53. Champy MF, Selloum M. Piard L, Zeitler V, Caradec C, Chambon P, Auwerx J.2004. Mouse functional genomics requires standardization of mouse handling and housing conditions. Mamm Genome, 15:768-783.
54. Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, Shapiro SD, Senior RM, Werb Z.1998. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell, 93:411-422.