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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2670-2674

Design and synthesis of potent, isoxazole-containing renin inhibitors

(20) Fournier, Pierre André a Arbour, Mélissa a Cauchon, Elizabeth a Chen, Austin a Chefson, Amandine a Ducharme, Yves a Falgueyret, Jean Pierre a Gagné, Sébastien a Grimm, Erich a Han, Yongxin a Houle, Robert a Lacombe, Patrick a Lévesque, Jean Franois a MacDonald, Dwight a MacKay, Bruce a McKay, Dan a Percival, M David a Ramtohul, Yeeman a St Jacques, René a Toulmond, Sylvie a

a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH (Canada)

Author keywords

Anti hypertensive; Inhibitor; Renin

Indexed keywords

CYTOCHROME P450 3A4; ISOXAZOLE DERIVATIVE; RENIN INHIBITOR;

ARTICLE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; PLASMA;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; CATALYTIC DOMAIN; DRUG DESIGN; ENZYME ACTIVATION; HUMANS; ISOXAZOLES; MOLECULAR STRUCTURE; RATS; RENIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863396689 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.03.014 Document Type: Article

Times cited : (13)

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