The effect of "Teucrium polium L." extracts on insulin release from in situ isolated perfused rat pancreas in a newly modified isolation method: The role of Ca2+ and K+ channels

Iranian Biomedical Journal

Volumn 14, Issue 4, 2010, Pages 178-185

  Mirghazanfari, Sayid Mahdi ^a,b   Keshavarz, Mansoor ^a   Nabavizadeh, Fatemeh ^a   Soltani, Nepton ^c   Kamalinejad, Mohammad ^d  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b AJA UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c HORMOZGAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Insulin; Pancreas; Perfusion; Teucrium extract

Indexed keywords

CALCIUM CHANNEL; DIAZOXIDE; INSULIN; POTASSIUM CHANNEL; TEUCRIUM POLIUM EXTRACT; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG EFFICACY; GAS CHROMATOGRAPHY; GERMANDER; INSULIN RELEASE; MALE; MASS SPECTROMETRY; NONHUMAN; PANCREAS; PILOT STUDY; PROTEIN ANALYSIS; PROTEIN FUNCTION; RAT;

ANIMALS; APIGENIN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; DIAZOXIDE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN; MALE; PANCREAS; PERFUSION; PLANT EXTRACTS; POTASSIUM CHANNELS; RATS; TEUCRIUM; TIME FACTORS; VERAPAMIL;

RATTUS; TEUCRIUM; TEUCRIUM POLIUM;

EID: 79951820496     PISSN: 1028852X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Shaw, J.E., Sicree, R.A. and Zimmet, P.Z. (2010) Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 87: 4-14.
2. Prashanth, M., Ganesh, H.K., Vima, M.V., John, M., Bandgar, T., Joshi, S.R., Shah, S.R., Rathi, P.M., Joshi, A.S., Thakkar, H., Menon, P.S. and Shah, N.S. (2009) Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. J. Assoc. Physicians India 57: 205-210.
3. Fayyad, A.M., Hill, S.R. and Jones, G. (2009) Prevalence and risk factors for bothersome lower urinary tract symptoms in women with diabetes mellitus from hospital-based diabetes clinic. Int Urogynecol J Pelvic Floor Dysfunct 20: 1339-1344.
4. Esteves, J.F., Kramer, C.K., Azevedo, M.J., Stolz, A.P., Roggia, M.F., Larangeira, A., Miozzo, S.A., Rosa, C., Lambert, J.H., Pecis, M., Rodrigues, T.C. and Canani, L.H. (2009) Prevalence of diabetic retinopathy in patients with type 1 diabetes mellitus. Rev Assoc Med Bras 55: 268-273.
5. (2002) WHO Traditional Medicine Strategy 2002-2005. Geneva
6. Afifia, F.U., Al-Khalidi, B. and Khalil, E. (2005) Studies on the in vivo hypoglycemic activities of two medicinal plants used in the treatment of diabetes in Jordanian traditional medicine following intranasal administration. J. Ethnopharmacol. 100: 314-318.
7. Esmaeili, M.A., Zohari, F. and Sadeghi, H. (2009) Antioxidant and protective effects of major flavonoids from Teucrium polium on beta-cell destruction in a model of streptozotocin-induced diabetes. Planta Med 75: 1418-1420.
8. Ardestani, A., Yazdanparast, R. and Jamshidi, S. (2008) Therapeutic effects of Teucrium polium extract on oxidative stress in pancreas of streptozotocin-induced diabetic rats. J. Med. Food 11: 525-532.
9. Ardestani, A. and Yazdanparast, R. (2007) Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation. Food Chem. Toxicol. 45: 2402-2411.
10. Ljubuncic, P., Dakwar, S., Portnaya, I., Cogan, U., Azaizeh, H. and Bomzon, A. (2006) Aqueous extracts of Teucrium polium possess remarkable antioxidant activity in vitro. Evid Based Complement Alternat. Med. 3: 329-338.
11. Azaizeh, H., Ljubuncic, P., Portnaya, I., Said, O., Cogan, U. and Bomzon, A. (2005) Fertilizationinduced changes in growth parameters and antioxidant activity of medicinal plants used in traditional arab medicine. Evid Based Complement Alternat. Med. 2: 549-556.
12. Suboh, S.M., Bilto, Y.Y. and Aburjai, T.A. (2004) Protective effects of selected medicinal plants against protein degradation, lipid peroxidation and deformability loss of oxidatively stressed human erythrocytes. Phytother. Res. 18: 280-284.
13. Tariq, M., Ageel, A.M., al-Yahya, M.A., Mossa, J.S. and al-Said, M.S. (1989) Anti-inflammatory activity of Teucrium polium. Int. J. Tissue React. 11: 185-188.
14. Capasso, F., Cerri, R., Morrica, P. and Senatore, F. (1983) Chemical composition and anti-inflammatory activity of an alcoholic extract of Teucrium polium L. Boll. Soc. Ital. Biol. Sper. 59: 1639-1643.
15. Baluchnejadmojarad, T., Roghani, M. and Roghani-Dehkordi, F. (2005) Antinociceptive effect of Teucrium polium leaf extract in the diabetic rat formalin test. J. Ethnopharmacol. 97: 207-210.
16. Abdollahi, M., Karimpour, H. and Monsef-Esfehani, H.R. (2003) Antinociceptive effects of Teucrium polium L. total extract and essential oil in mouse writhing test. Pharmacol. Res. 48: 31-35.
17. Aggelis, G., Athanassopoulos, N., Paliogianni, A. and Komaitis, M. (1998) Effect of a Teucrium polium L. extract on the growth and fatty acid composition of Saccharomyces cerevisiae and Yarrowia lipolytica. Antonie Van Leeuwenhoek 73: 195-198.
18. Autore, G., Capasso, F., De Fusco, R., Fasulo, M.P., Lembo, M., Mascolo, N. and Menghini, A. (1984) Antipyretic and antibacterial actions of Teucrium polium (L.). Pharmacol Res Commun 16: 21-29.
19. Rasekh, H.R., Khoshnood-Mansourkhani, M.J. and Kamalinejad, M. (2001) Hypolipidemic effects of Teucrium polium in rats. Fitoterapia 72: 937-939.
20. Amini, R., Nosrati, N., Yazdanparast, R. and Molaei, M. (2009) Teucrium poliumin prevention of steatohepatitis in rats. Liver Int. 29: 1216-1221.
21. Panovska, T.K., Kulevanova, S., Gjorgoski, I., Bogdanova, M. and Petrushevska, G. (2007) Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachlorideinduced hepatic injury in rats. Acta Pharm. 57: 241-248.
22. Mehrabani, D., Rezaee, A., Azarpira, N., Fattahi, M.R., Amini, M., Tanideh, N., Panjehshahin, M.R. and Saberi-Firouzi, M. (2009) The healing effects of Teucrium polium in the repair of indomethacininduced gastric ulcer in rats. Saudi Med. J. 30: 494-499.
23. Rajabalian, S. (2008) Methanolic extract of Teucrium polium L. potentiates the cytotoxic and apoptotic effects of anticancer drugs of vincristine, vinblastine and doxorubicin against a panel of cancerous cell lines. Exp. Oncol. 30: 133-138.
24. Shahraki, M.R., Arab, M.R., Mirimokaddam, E. and Palan, M.J. (2007) The effect of Teucrium polium (Calpoureh) on liver function, serum lipids and glucose in diabetic male rats. Iran. Biomed. J. 11: 65-68.
25. Esmaeili, M.A. and Yazdanparast, R. (2004) Hypoglycaemic effect of Teucrium polium: studies with rat pancreatic islets. J. Ethnopharmacol. 95: 27-30.
26. Gharaibeh, M.N., Elayan, H.H. and Salhab, A.S. (1988) Hypoglycemic effects of Teucrium polium. J. Ethnopharmacol. 24: 93-99.
27. Mohseni Salehi Monfared, S.S. and Pournourmohammadi, S. (2009) Teucrium polium Complex with Molybdate Enhance Cultured Islets Secretory Function. Biol. Trace Elem. Res. 133: 236-241.
28. Lenzen, S. (1979) Insulin secretion by isolated perfused rat and mouse pancreas. Am. J. Physiol. 236: E391-400.
29. Deacon, C., Plamboeck, A., Rosenkilde, M., Heer, j. and Holst, J. (2006) GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations. Am. J. Physiol. Endocrinol. Metab. 291: 468-475.
30. Tirone, T.A., Norman, M.A., Moldovan, S., DeMayo, F.J., Wang, X.P. and Brunicardi, F.C. (2003) Pancreatic somatostatin inhibits insulin secretion via SSTR-5 in the isolated perfused mouse pancreas model. Pancreas 26: e67-73.
31. Sharififar, F., Dehghn-Nudeh, G. and Mirtajaldini, M. (2009) Major flavonoids with antioxidant activity from Teucrium polium L. Food Chemistry 112: 885-888.
32. Carreiras, M., Rodríguez, B., Piozzia, F., Savonaa, G., Torres, M. and Perales, A. (1989) A chlorinecontaining and two 17β-neo-clerodane diterpenoids from Teucrium polium subsp. Vincentinum. Phytochemistry 28: 1453-1461.
33. Verykokidou-Vitsaropoulou, E. and Vajias, C. (1986) Methylated Flavones from Teucrium polium. Planta Med. 52: 401-402.
34. Fernandes, A., Novelli, E., Okoshi, K., Okoshi, M., Muzio, B., Guimarães, J. and Junior, A. (2009) Influence of rutin treatment on biochemical alterations in experimental diabetes. Biomed. Pharmacother. 64: 214-219.
35. Cazarolli, L.H., Folador, P., Moresco, H.H., Brighente, I.M., Pizzolatti, M.G. and Silva, F.R. (2009) Stimulatory effect of apigenin-6-C-beta-Lfucopyranoside on insulin secretion and glycogen synthesis. Eur. J. Med. Chem. 44: 4668-4673.
36. Cazarolli, L.H., Folador, P., Moresco, H.H., Brighente, I.M., Pizzolatti, M.G. and Silva, F.R. (2009) Mechanism of action of the stimulatory effect of apigenin-6-C-(2''-O-alpha-l-rhamnopyranosyl)- beta-L-fucopyranoside on 14C-glucose uptake. Chem. Biol. Interact. 179: 407-412.
37. Ardestani, A. and Yazdanparast, R. (2007) Flavonoids as potential therapeutic agents for type 1 diabetes. Med. Hypoth. 69: 955.
38. Yang, S.N. and Berggren, P.O. (2005) Beta-cell CaV channel regulation in physiology and pathophysiology. Am. J. Physiol. Endocrinol. Metab. 288: E16-28.
39. Stumvoll, M., Goldstein, B.J. and van Haeften, T.W. (2005) Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365: 1333-1346.
40. Herrington, J., Zhou, Y.P., Bugianesi, R.M., Dulski, P.M., Feng, Y., Warren, V.A., Smith, M.M., Kohler, M.G., Garsky, V.M., Sanchez, M., et al. (2006) Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes 55: 1034-1042.
41. Hoy, M., Olsen, H.L., Andersen, H.S., Bokvist, K., Buschard, K., Hansen, J., Jacobsen, P., Petersen, J.S., Rorsman, P. and Gromada, J. (2003) Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells. Eur. J. Pharmacol. 466: 213-221.