Regulatory factor X1-induced down-regulation of transforming growth factor β2 transcription in human neuroblastoma cells

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 22730-22739

  Feng, Chenzhuo ^a   Zuo, Zhiyi ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FUNCTIONS; CANCER DEVELOPMENT; DOWN-REGULATION; ERK ACTIVATION; HUMAN BRAIN TUMORS; HUMAN NEUROBLASTOMA; HUMAN TUMORS; IMMUNOPRECIPITATION ASSAYS; MEDULLOBLASTOMA; NEURONAL CELL; OVER-EXPRESSION; PROMOTER ACTIVITIES; REGULATORY FACTORS; SIGNAL-REGULATED KINASE; SIGNALING PATHWAYS; TRANSFORMING GROWTH FACTORS;

BRAIN; CELL CULTURE; CELL PROLIFERATION; HISTOLOGY; MAMMALS; TISSUE; TRANSCRIPTION; TRANSCRIPTION FACTORS;

CELLS;

MITOGEN ACTIVATED PROTEIN KINASE; REGULATORY FACTOR X1; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER TISSUE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; MEDULLOBLASTOMA; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

CELL DIVISION; CELL LINE, TUMOR; CEREBELLAR NEOPLASMS; DNA-BINDING PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MEDULLOBLASTOMA; NEUROBLASTOMA; NEURONS; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA2;

BOVINAE; MAMMALIA;

EID: 84863332576     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.338590     Document Type: Article

References (23)

1. Emery, P., Durand, B., Mach, B., and Reith, W. (1996) RFX proteins, a novel family of DNA-binding proteins conserved in the eukaryotic kingdom. Nucleic Acids Res. 24, 803-807 (Pubitemid 26076182)
2. Aftab, S., Semenec, L., Chu, J. S., and Chen, N. (2008) Identification and characterization of novel human tissue-specific RFX transcription factors. BMC Evol. Biol. 8, 226
3. Clausen, B. E., Waldburger, J. M., Schwenk, F., Barras, E., Mach, B., Rajewsky, K., Förster, I., and Reith, W. (1998) Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Immunity 8, 143-155 (Pubitemid 28123742)
4. Ma, K., Zheng, S., and Zuo, Z. (2006) The transcription factor regulatory factor X1 increases the expression of neuronal glutamate transporter type 3. J. Biol. Chem. 281, 21250-21255 (Pubitemid 44115464)
5. Feng, C., Li, J., and Zuo, Z. (2011) Monoallelic expression of regulatory factor X1 in mouse brain. Folia Histochem. Cytobiol. 49, 344-351
6. Hsu, Y. C., Liao, W. C., Kao, C. Y., and Chiu, I. M. (2010) Regulation of FGF1 gene promoter through transcription factor RFX1. J. Biol. Chem. 285, 13885-13895
7. Chen, L., Smith, L., Johnson, M. R., Wang, K., Diasio, R. B., and Smith, J. B. (2000) Activation of protein kinase C induces nuclear translocation of RFX1 and down-regulates c-myc via an intron 1X box in undifferentiated leukemia HL-60 cells. J. Biol. Chem. 275, 32227-32233
8. Ohashi, Y., Ueda, M., Kawase, T., Kawakami, Y., and Toda, M. (2004) Identification of an epigenetically silenced gene, RFX1, in human glioma cells using restriction landmark genomic scanning. Oncogene 23, 7772-7779 (Pubitemid 39457027)
9. Blobe, G. C., Schiemann, W. P., and Lodish, H. F. (2000) Role of transforming growth factor β in human disease. N. Engl. J. Med. 342, 1350-1358 (Pubitemid 30408720)
10. Massagué, J. (2008) TGFβ in cancer. Cell 134, 215-230
11. Shah, C. A., Wang, H., Bei, L., Platanias, L. C., and Eklund, E. A. (2011) HoxA10 regulates transcription of the gene encoding transforming growth factor β2 (TGFβ2) in myeloid cells. J. Biol. Chem. 286, 3161-3176
12. Feng, C., Cao, L., and Zuo, Z. (2011) RNA interference-produced autoregulation of inducible nitric-oxide synthase expression. FEBS Lett. 585, 2488-2492
13. Crews, C. M., Alessandrini, A., and Erikson, R. L. (1992) The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 258, 478-480
14. 2+-dependent survival signaling in cortical neurons and modulatesMAPkinases, apoptosis proteins and transcription factors during hypoxia. Anesth. Analg. 103, 419-429
15. Yao, Y., Li, W., Wu, J., Germann, U. A., Su, M. S., Kuida, K., and Boucher, D. M. (2003) Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation. Proc. Natl. Acad. Sci. U.S.A. 100, 12759-12764 (Pubitemid 37339972)
16. Liu, I. M., Schilling, S. H., Knouse, K. A., Choy, L., Derynck, R., and Wang, X. F. (2009) TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch. EMBO J. 28, 88-98
17. Zhai, Y., Gao, X., Wu, Q., Peng, L., Lin, J., and Zuo, Z. (2008) Fluvastatin decreases cardiac fibrosis possibly through regulation of TGF-β1/Smad 7 expression in the spontaneously hypertensive rats. Eur. J. Pharmacol. 587, 196-203
18. Liu, M., Lee, B. H., and Mathews, M. B. (1999) Involvement of RFX1 protein in the regulation of the human proliferating cell nuclear antigen promoter. J. Biol. Chem. 274, 15433-15439
19. Bravo, R., Frank, R., Blundell, P. A., and Macdonald-Bravo, H. (1987) Cyclin/ PCNA is the auxiliary protein of DNA polymerase-δ. Nature 326, 515-517 (Pubitemid 17055498)
20. Prelich, G., Kostura, M., Marshak, D. R., Mathews, M. B., and Stillman, B. (1987) The cell cycle-regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro. Nature 326, 471-475 (Pubitemid 17055490)
21. Eckenstein, F. P., Andersson, C., Kuzis, K., and Woodward, W. R. (1994) Distribution of acidic and basic fibroblast growth factors in the mature, injured and developing rat nervous system. Prog. Brain Res. 103, 55-64
22. Nurcombe, V., Ford, M. D., Wildschut, J. A., and Bartlett, P. F. (1993) Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan. Science 260, 103-106 (Pubitemid 23122755)
23. Watts, J. A., Zhang, C., Klein-Szanto, A. J., Kormish, J. D., Fu, J., Zhang, M. Q., and Zaret, K. S. (2011) Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development. PLoS Genet. 7, e1002277