A new catheter for tumor targeting with radioactive microspheres in representative hepatic artery systems. Part I: Impact of catheter presence on local blood flow and microsphere delivery

Journal of Biomechanical Engineering

Volumn 134, Issue 5, 2012, Pages

  Kleinstreuer, C ^a,b   Basciano, C A ^c   Childress, E M ^d   Kennedy, A S ^e  

^a Biomedical Research Imaging Center   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c APPLIED RESEARCH ASSOCIATES   (United States)

^d North Carolina State University   (United States)

^e Cancer Centers of North Carolina   (United States)

Author keywords

adjustable catheter; blood flow; computer simulations; hepatic artery system; microsphere transport

Indexed keywords

BLOOD FLOW; ENGINEERING SOFTWARE; HEPATIC ARTERY; INJECTION SPEED; INTERNAL RADIATION; LIVER TUMORS; LOCAL INFLUENCE; MEDICAL DATA SETS; PARTICLE RELEASE; PARTICLE TRANSPORT; RADIOACTIVE MICROSPHERES; TRANSPORT PHENOMENA; TUMOR TARGETING; YTTRIUM-90;

BLOOD VESSELS; CATHETERS; CHEMOTHERAPY; COMPUTER SIMULATION; HEMODYNAMICS; LAMINAR FLOW; LIVER; OPTIMIZATION; RADIOACTIVITY; THREE DIMENSIONAL; TUMORS; YTTRIUM;

MICROSPHERES;

ANTINEOPLASTIC AGENT; RADIOACTIVE MICROSPHERE; SIR SPHERES; THERESPHERES; UNCLASSIFIED DRUG; YTTRIUM 90; MICROSPHERE; YTTRIUM;

ARTERY BLOOD FLOW; ARTERY CATHETER; ARTICLE; BIOENGINEERING; BLOOD VESSEL; CANCER PATIENT; CASE REPORT; CHEMORADIOTHERAPY; CONTRAST ENHANCEMENT; CONTROLLED DRUG RELEASE; CROSS-SECTIONAL STUDY; DATA ANALYSIS SOFTWARE; DRUG DELIVERY SYSTEM; DRUG TARGETING; HEPATIC ARTERY; HUMAN; INJECTION; LIVER TUMOR; PARTICLE SIZE; SMART MICROCATHETER; THREE DIMENSIONAL IMAGING; ARTIFICIAL EMBOLISM; BLOOD FLOW; CATHETER; INSTRUMENTATION; LIVER CELL CARCINOMA; PATHOPHYSIOLOGY; VASCULARIZATION;

CARCINOMA, HEPATOCELLULAR; CATHETERS; DRUG DELIVERY SYSTEMS; EMBOLIZATION, THERAPEUTIC; HEPATIC ARTERY; HUMANS; LIVER NEOPLASMS; MICROSPHERES; REGIONAL BLOOD FLOW; YTTRIUM RADIOISOTOPES;

EID: 84863331194     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.4006684     Document Type: Article

References (19)

1. Kennedy, A., Nag, S., Salem, R., Murthy, R., McEwan, A. J., Nutting, C., Benson, A., Eespat, J., Bilbao, J. I., Sharma, R. A., Thomas, J. P., and Coldwell, D., 2007, Recommendations for Radioembolizations of Hepatic Malignancies Using Yttrium-90 Microsphere Brachytherapy: A Concensus Panel Report From the Radioembolization Brachytherapy Oncology Consortium., Int. J. Radiat. Oncol. Biol. Phys. (Red Journal), 68 (1), pp. 13-3. (Pubitemid 46589861)
2. 90Y-Microsphere Brachytherapy for Unresectable Colorectal Liver Metastases: Modern USA Experience., Int. J. Radiat. Oncol. Biol. Phys. (Red Journal), 65 (2), pp. 412-425.
3. Kennedy, A. S., and Salem, R., 2010, Radioembolization (Yttrium-90 Microspheres) for Primary and Metastatic Hepatic Malignancies., Cancer J., 16 (2), pp. 163-175.
4. Kleinstreuer, C., 2011, Methods and Devices for Targeted Injection of Radioactive Microspheres., U.S. Patent and PCT Int'l Application No. PCT/US2010/043552, NC State University, Raleigh, NC.
5. Basciano, C. A., Kleinstreuer, C., Kennedy, A. S., Dezarn, W. A., and Childress, E., 2010, Computer Modeling of Controlled Microsphere Release and Targeting in a Representative Hepatic Artery System., Ann. Biomed. Eng., 38 (5), pp. 1862-1879.
6. 90Y Microsphere Transport in the Hepatic Arterial Tree to Improve Clinical Outcomes., Int. J. Radiat. Oncol. Biol. Phys. (Red Journal), 76 (2), pp. 631-637.
7. Kleinstreuer, C., 2006, Biofluid Dynamics: Principles and Selected Applications, CRC, Taylor and Francis, Boca Raton, FL.
8. Kao, Y. H., Tan, A. E. H., Ng, D. C. E., and Goh, A. S. W., 2011, Controversy in Yttrium-90 Selective Internal Radiation Therapy: Imaging Discordance between Catheter-Directed CT Hepatic Angiography Versus Tc-99m-MAA SPECT/CT as a Possible First Human Demonstration of In-Vivo Microparticle Trajectory Selection for Specific Daughter Vessel Targeting., J. Nucl. Med., 52 (Supplement 1), p. 1083.
9. Ishigami, K., Zhang, Y., Rayhill, S., Katz, D., and Stolpen, A., 2004, Does Variant Hepatic Artery Anatomy in a Liver Transplant Recipient Increase the Risk of Hepatic Artery Complications after Transplantation, Am. J. Roentgenol., 183, pp. 1577-1584. (Pubitemid 44210523)
10. Carlisle, K. M., Halliwell, M., Read, A. E., and Wells, P. N., 1992, Estimation of Total Hepatic Flow by Duplex Ultrasound., Gut, 33, pp. 92-97.
11. Han, S. H. B., Rice, S., Cohen, S. M., Reynolds, T. B., and Fong, T. L., 2002, Duplex Doppler Ultrasound of the Hepatic Artery in Patients With Acute Alcoholic Hepatitis., J. Clin. Gastroenterol., 34 (5), pp. 573-577. (Pubitemid 34429421)
12. Jin, N., Lewandowski, R. J., Omary, R. A., and Larson, A. C., 2009, Respiratory Self-Gaiting for Free-Breathing Abdominal Phase-Contrast Blood Flow Measurements., J. Magn. Reson. Imaging, 29, pp. 860-868.
13. Murthy, R., Nunez, R., Szklaruk, J., Erwin, W., Madoff, D. C., Gupta, S., Ahar, K., Wallace, M. J., Cohen, A., Coldwell, D. M., Kennedy, A. S., and Hicks, M. E., 2005, Yttrium-90 Microsphere Therapy for Hepatic Malignancy: Devices, Indications, Technical Considerations, and Potential Complications., RadioGraphics, 25, pp. S41-S55.
14. Buchanan, J. R., Kleinstreuer, C., and Comer, J. K., 2000, Rheological Effects onPulsatile Hemodynamics in a Stenosed Tube., Comput. Fluids, 29, pp. 695-724. (Pubitemid 30306543)
15. Merrill, E. W., 1969, Rheology of Blood., Physiol. Rev., 49 (4), pp. 863-888.
16. Hyun, S., Kleinstreuer, C., Longest, P. W., and Chen, C., 2004, Particle-Hemodynamics Simulations and Design Options for Surgical Reconstruction of Diseased Carotid Artery Bifurcations., ASME J. Biomech. Eng., 126 (2), pp. 188-195. (Pubitemid 38621131)
17. Longest, P. W., Kleinstreuer, C., and Buchanan, J. R., 2004, Efficient Computation of Micro-Particle Dynamics including Wall Effects., Comput. Fluids, 33, pp. 577-601. (Pubitemid 37358727)
18. Basciano, C. A., 2010, Computational Particle-Hemodynamics Analysis Applied to an Abdominal Aortic Aneurysm With Thrombus and Microsphere-Targeting of Liver Tumors., Ph.D. dissertation, Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC.
19. Richards, A. L., Kleinstreuer, C., Kennedy, A. S., Childress, E., and Buckner, G. D., 2012, Experimental Microsphere Targeting in a Representative Hepatic Artery System., IEEE Trans. Biomed. Eng., 59, pp. 198-204.