Computer modeling of controlled microsphere release and targeting in a representative hepatic artery system

Annals of Biomedical Engineering

Volumn 38, Issue 5, 2010, Pages 1862-1879

  Basciano, Christopher A ^a   Kleinstreuer, Clement ^a,b   Kennedy, Andrew S ^c   Dezarn, William A ^c   Childress, Emily ^a  

^a North Carolina State University   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c Wake Radiology Oncology   (United States)

Author keywords

Computational fluid particle dynamics; Drug targeting methodology; Non Newtonian fluid; Transient particle hemodynamics; Yttrium 90 particle transport

Indexed keywords

COMPUTATIONAL FLUID; DRUG-TARGETING; NON-NEWTONIAN FLUIDS; PARTICLE DYNAMICS; PARTICLE TRANSPORT; YTTRIUM-90;

COMPUTATIONAL FLUID DYNAMICS; COMPUTER CONTROL SYSTEMS; FLOW MEASUREMENT; FLUIDS; HEMODYNAMICS; HYDRODYNAMICS; LIVER; MICROSPHERES; NEWTONIAN LIQUIDS; NON NEWTONIAN FLOW; PARTICLE SEPARATORS; RHEOLOGY; THREE DIMENSIONAL; TUMORS; VELOCITY MEASUREMENT; VISCOUS FLOW; YTTRIUM; YTTRIUM ALLOYS;

TRANSPORT PROPERTIES;

MICROSPHERE; YTTRIUM;

ANIMAL; ARTICLE; COMPUTER SIMULATION; DRUG DELIVERY SYSTEM; HEMODYNAMICS; HEPATIC ARTERY; LIVER; LIVER TUMOR; METHODOLOGY; PHYSIOLOGY; VASCULARIZATION;

ANIMALS; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; HEMODYNAMICS; HEPATIC ARTERY; LIVER; LIVER NEOPLASMS; MICROSPHERES; YTTRIUM;

EID: 77952008886     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-010-9955-z     Document Type: Article

References (34)

1. CS Ahn SG Lee S Hwang DB Moon TY Ha YJ Lee KM Park KH Kim YD Kim KK Kim 2005 Anatomic variation of the right hepatic artery and its reconstruction for living donor liver transplantation using right lobe graft Transplant. Proc. 37 1067 1069 10.1016/j.transproceed.2005.01.068 15848624 (Pubitemid 40590792)
2. Basciano, C. A. Computational particle hemodynamics analyses with applications to abdominal aortic aneurysms and liver targeting. PhD Dissertation under Prof. Clement Kleinstreuer at North Carolina State University, Raleigh, NC, 2010.
3. AS Befeler AM Di Bisceglie 2002 Hepatocellular carcinoma: diagnosis and treatment Gastroenterology 122 1609 1619 10.1053/gast.2002.33411 12016426
4. JI Bilbao A Martino E Luis L Díaz-Dorronsoro A Alonso-Burgos A Martinez de la Cuesta B Sangro JA García de Jalón 2009 Biocompatability, inflammatory response, and recannalization characteristics of nonradioactive resin microspheres: histological findings Cardiovasc. Inter. Rad. 32 727 736 10.1007/s00270-009-9592-9
5. J Bruix M Sherman 2005 Management of hepatocellular carcinoma Hepatology 6 1208 1236 10.1002/hep.20933 (Pubitemid 43112690)
6. Buchanan, J. R. Computational particle hemodynamics in the rabbit abdominal aorta. PhD Dissertation under Prof. Clement Kleinstreuer at North Carolina State University, Raleigh, NC, 2000.
7. JR Buchanan C Kleinstreuer JK Comer 2000 Rheological effects on pulsatile hemodynamics in a stenosed tube Comp. Fluids 29 695 724 10.1016/S0045-7930(99) 00019-5 (Pubitemid 30306543)
8. D Bushi Y Grad S Einav O Yodfat B Nishri D Tanne 2005 Hemodynamic evaluation of embolic trajectory in an arterial bifurcation: an in-vitro experimental model Stroke 36 2696 2700 10.1161/01.STR.0000190097.08862.9a 16269629
9. G Cabibbo F Latteri M Antonucci A Craxi 2009 Multimodal approaches to the treatment of hepatocellular carcinoma Nat. Clin. Pract. Gastroenterol. Hepatol. 6 159 169 10.1038/ncpgasthep1357 19190599
10. KM Carlisle M Halliwell AE Read PN Wells 1992 Estimation of total hepatic flow by duplex ultrasound Gut 33 92 97 10.1136/gut.33.1.92 1:STN:280: DyaK387lsFGnsg%3D%3D 1740284
11. LA da Silveira FBC Silveira VPS Fazan 2009 Arterial diameter of the celiac trunk and its branches. Anatomical study Acta Cir. Bras. 24 1 044 047 10.1590/S0102-86502009000100009
12. SHB Han S Rice SM Cohen TB Reynolds TL Fong 2002 Duplex Doppler ultrasound of the hepatic artery in patients with acute alcoholic hepatitis J. Clin. Gastroenterol. 34 5 573 577 10.1097/00004836-200205000-00019 11960073 (Pubitemid 34429421)
13. JR Hiatt J Gabbay RW Busuttil. 1994 Surgical anatomy of the hepatic arteries in 1000 cases Ann. Surg. 220 1 50 52 10.1097/00000658-199407000-00008 1:STN:280:DyaK2c3ps1WksA%3D%3D 8024358
14. GH Hübner N Steudel G Kleber C Behrmann E Lotterer WE Fleig 2000 Hepatic artery blood flow velocities: assessment by transcutaneous and intravascular Doppler sonography J. Hepatol. 32 893 899 10.1016/S0168-8278(00) 80093-8 10898309 (Pubitemid 30368082)
15. K Ishigami Y Zhang S Rayhill D Katz A Stolpen 2004 Does variant hepatic artery anatomy in a liver transplant recipient increase the risk of hepatic artery complications after transplantation Am. J. Roentgenol. 183 1577 1584
16. F Jakab Z Rath F Schmal P Nagy J Falller 1996 Changes in hepatic hemodynamics due to primary liver tumours HPB Surg. 9 245 248 10.1155/1996/62057 1:STN:280:DyaK28vgsFCntQ%3D%3D 8809587
17. N Jin RJ Lewandowski RA Omary AC Larson 2009 Respiratory self-gaiting for free-breathing abdominal phase-contrast blood flow measurements J. Magn. Reson. Imaging 29 860 868 10.1002/jmri.21711 19306414
18. 90Y-Microsphere brachytherapy for unresectable colorectal liver metastases: modern USA experience Int. J. Radiat. Oncol. 65 2 412 425 10.1016/j.ijrobp.2005.12.051 1:CAS:528:DC%2BD28XksVCktLY%3D
19. 90Y microsphere transport in the hepatic arterial tree to improve clinical outcomes Int. J. Radiat. Oncol. 76 2 631 637 10.1016/j.ijrobp.2009.06. 069 1:CAS:528:DC%2BC3cXnt1WltA%3D%3D
20. A Kennedy S Nag R Salem R Murthy AJ McEwan C Nutting A Benson J Eespat JI Bilbao RA Sharma JP Thomas D Coldwell 2007 Recommendations for radioembolizations of hepatic malignancies using yttrium-90 microsphere brachytherapy: a concensus panel report from the radioembolization brachytherapy oncology consortium Int. J. Radiat. Oncol. 68 1 13 23 10.1016/j.ijrobp.2006.11. 060 (Pubitemid 46589861)
21. 90Y microspheres in man: review of four explanted whole livers Int. J. Radiat. Oncol. 60 5 1552 1563 10.1016/j.ijrobp.2004.09.004 1:CAS:528:DC%2BD2cXhtVKrtLzO (Pubitemid 39601873)
22. Y Kito M Nagino Y Nimura 2001 Doppler sonography of hepatic arterial blood flow velocity after percutaneous transhepatic portal vein embolization Am. J. Roentgenol. 176 909 912 1:STN:280:DC%2BD3M7msF2ltw%3D%3D
23. Kleinstreuer, C. Biofluid Dynamics: Principles and Selected Applications. Boca Raton, FL: CRC Press, pp. 78-108, 243-421, 2006.
24. Kleinstreuer, C. Methods and devices for targeted injection of radioactive microspheres. U.S. Patent Application 61/127,889, July 28, 2009, NC State University, Raleigh, NC.
25. C Kleinstreuer Z Zhang JF Donohue 2008 Targeted drug-aerosol delivery in the human respiratory system Annu. Rev. Biomed. Eng. 10 195 220 10.1146/annurev.bioeng.10.061807.160544 1:CAS:528:DC%2BD1cXhtVGru7nJ 18412536
26. A Koops B Wojciechowski DC Broering G Adam G Krupski-Berdien 2004 Anatomic variations of the hepatic arteries in 604 selective celiac and superior mesenteric angiographies Surg. Radiol. Anat. 26 239 244 10.1007/s00276-004- 0229-z 1:STN:280:DC%2BD2c3nsFWgtg%3D%3D 14968265 (Pubitemid 38868292)
27. JB Kruskal PA Newman LG Sammons RA Kane 2004 Optimizing Doppler and color flow US: application to hepatic sonography RadioGraphics 24 657 675 10.1148/rg.243035139 15143220
28. LX Liu WH Zhang HC Jiang 2003 Current treatment for liver metastases from colorectal cancer World J. Gastroenterol. 9 2 193 200 12532430
29. PW Longest C Kleinstreuer RR Buchanan 2004 Efficient computation of micro-particle dynamics including wall effects Comput. Fluids 33 577 601 10.1016/j.compfluid.2003.06.002 (Pubitemid 37358727)
30. NA Michels 1966 Newer anatomy of the liver and its variant blood supply and collateral circulation Am. J. Surg. 112 337 347 10.1016/0002-9610(66)90201-7 1:STN:280:DyaF2s%2FhtlOrsg%3D%3D 5917302
31. LE Patruno AHV Repetto Llamazares MO Prado 2006 Simulation of arterial hemodynamics for brachytherapy applications Mecánica Computacional 25 2539 2548
32. P Pouponneau J-C Leroux S Martel 2009 Magnetic nanoparticles encapsulated into biodegradable microparticles steered with an upgraded magnetic resonance imaging system for tumor chemoembolization Biomaterials 30 6327 6332 10.1016/j.biomaterials.2009.08.005 1:CAS:528:DC%2BD1MXhtFWltb3E 19695700
33. KJW Taylor PN Burns JP Woodcock PNT Wells 1985 Blood flow in deep abdominal and pelvic vessels: ultrasonic pulsed-Doppler analysis Radiology 154 487 493 1:STN:280:DyaL2M%2FovFeksw%3D%3D 3880913
34. Truskey, G. A., F. Yuan, and D. F. Katz. Transport Phenomena in Biological Systems. Upper Saddle River, NJ: Pearson Prentice Hall, p. 226, 2004.