Metabolic imaging of mild traumatic brain injury

Brain Imaging and Behavior

Volumn 6, Issue 2, 2012, Pages 208-223

  Lin, A P ^a   Liao, H J ^a   Merugumala, S K ^a   Prabhu, S P ^b   Meehan III, W P ^b   Ross, B D ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HUNTINGTON MEDICAL RESEARCH INSTITUTES   (United States)

Author keywords

Metabolic imaging; Mild traumatic brain injury; Positron emission tomography; Single photon emission computed tomography; Spectroscopy

Indexed keywords

CYSTEINE ETHYL ESTER TC 99M; FLUORODEOXYGLUCOSE F 18; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; IOMAZENIL I 123;

ARTICLE; BRAIN BLOOD FLOW; BRAIN CONCUSSION; BRAIN REGION; CEREBELLUM; CONTRAST ENHANCEMENT; CORPUS CALLOSUM; DRUG ACCUMULATION; DRUG HALF LIFE; GLASGOW COMA SCALE; HEAD INJURY; HIPPOCAMPUS; HUMAN; INJURY SEVERITY; ISOTOPE LABELING; MOTOR CORTEX; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPORT INJURY; TEMPORAL LOBE; TRAUMATIC BRAIN INJURY; UNCONSCIOUSNESS; WHITE MATTER;

BRAIN; BRAIN INJURIES; BRAIN MAPPING; FUNCTIONAL NEUROIMAGING; HUMANS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 84863319885     PISSN: 19317557     EISSN: 19317565     Source Type: Journal    
DOI: 10.1007/s11682-012-9181-4     Document Type: Article

References (64)

1. Abu-Judeh, H. H., Singh, M., Masdeu, J. C., & Abdel-Dayem, H. M. (1998). Discordance between FDG uptake and technetium-99 m-HMPAO brain perfusion in acute traumatic brain injury. J Nucl Med, 39(8), 1357-1359.
2. Amen, D. G., Newberg, A., Thatcher, R., Jin, Y., Wu, J., Keator, D., et al. (2011). Impact of playing American professional football on long-term brain function. J Neuropsychiatry Clin Neurosci, 23(1), 98-106.
3. Amen, D. G., Wu, J. C., Taylor, D., & Willeumier, K. (2011). Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation. J Psychoactive Drugs, 43(1), 1-5.
4. Ashwal, S., Holshouser, B., Tong, K., Serna, T., Osterdock, R., Gross, M., et al. (2004). Proton spectroscopy detected myoinositol in children with traumatic brain injury. Pediatr Res, 56(4), 630-638.
5. Audenaert, K., Jansen, H. M., Otte, A., Peremans, K., Vervaet, M., Crombez, R., et al. (2003). Imaging of mild traumatic brain injury using 57Co and 99mTc HMPAO SPECT as compared to other diagnostic procedures. Med Sci Monit, 9(10), MT112-117.
6. Baugh, C. M., Stamm, J. M., Riley, D. O., Gavett, B. E., Shenton, M. E., Lin, A., et al. (2012). Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging Behav, doi: 10. 1007/s11682-012-9164-5.
7. Belanger, H. G., Vanderploeg, R. D., Curtiss, G., & Warden, D. L. (2007). Recent neuroimaging techniques in mild traumatic brain injury. J Neuropsychiatry Clin Neurosci, 19(1), 5-20.
8. Bigler, E. D., & Maxwell, W. L. (2012). Neuropathology of mild traumatic brain injury: relationship to neuroimaging findings. Brain Imaging Behav, doi: 10. 1007/s11682-011-9145-0.
9. Bluml, S., & Brooks, W. M. (2006). Magnetic resonance spectroscopy of traumatic brain injury and concussion. In S. M. Slobounov & W. J. Sebastianelli (Eds.), Foundations of sports-related brain injuries (Vol. 1, pp. 197-220). New York: Springer.
10. Bonne, O., Gilboa, A., Louzoun, Y., Kempf-Sherf, O., Katz, M., Fishman, Y., et al. (2003). Cerebral blood flow in chronic symptomatic mild traumatic brain injury. Psychiatry Res, 124(3), 141-152.
11. Catafau, A. M. (2001). Brain SPECT in clinical practice. Part I: perfusion. J Nucl Med, 42(2), 259-271.
12. Cecil, K. M., Hills, E. C., Sandel, M. E., Smith, D. H., McIntosh, T. K., Mannon, L. J., et al. (1998). Proton magnetic resonance spectroscopy for detection of axonal injury in the splenium of the corpus callosum of brain-injured patients. J Neurosurg, 88(5), 795-801.
13. Chen, S. H., Kareken, D. A., Fastenau, P. S., Trexler, L. E., & Hutchins, G. D. (2003). A study of persistent post-concussion symptoms in mild head trauma using positron emission tomography. J Neurol Neurosurg Psychiatry, 74(3), 326-332.
14. Cimatti, M. (2006). Assessment of metabolic cerebral damage using proton magnetic resonance spectroscopy in mild traumatic brain injury. J Neurosurg Sci, 50(4), 83-88.
15. Cohen, B. A., Inglese, M., Rusinek, H., Babb, J. S., Grossman, R. I., & Gonen, O. (2007). Proton MR spectroscopy and MRI-volumetry in mild traumatic brain injury. AJNR Am J Neuroradiol, 28(5), 907-913.
16. Definition of mild traumatic brain injury (1993). The Journal of Head Trauma Rehabilitation, 8(3), 86-87.
17. Garnett, M. R., Blamire, A. M., Corkill, R. G., Cadoux-Hudson, T. A., Rajagopalan, B., & Styles, P. (2000). Early proton magnetic resonance spectroscopy in normal-appearing brain correlates with outcome in patients following traumatic brain injury. Brain, 123(Pt 10), 2046-2054.
18. Gasparovic, C., Yeo, R., Mannell, M., Ling, J., Elgie, R., Phillips, J., et al. (2009). Neurometabolite concentrations in gray and white matter in mild traumatic brain injury: an 1H-magnetic resonance spectroscopy study. J Neurotrauma, 26(10), 1635-1643.
19. Govindaraju, V., Gauger, G. E., Manley, G. T., Ebel, A., Meeker, M., & Maudsley, A. A. (2004). Volumetric proton spectroscopic imaging of mild traumatic brain injury. AJNR Am J Neuroradiol, 25(5), 730-737.
20. Gowda, N. K., Agrawal, D., Bal, C., Chandrashekar, N., Tripati, M., Bandopadhyaya, G. P., et al. (2006). Technetium Tc-99 m ethyl cysteinate dimer brain single-photon emission CT in mild traumatic brain injury: a prospective study. AJNR Am J Neuroradiol, 27(2), 447-451.
21. Gray, B. G., Ichise, M., Chung, D. G., Kirsh, J. C., & Franks, W. (1992). Technetium-99 m-HMPAO SPECT in the evaluation of patients with a remote history of traumatic brain injury: a comparison with x-ray computed tomography. J Nucl Med, 33(1), 52-58.
22. Gross, H., Kling, A., Henry, G., Herndon, C., & Lavretsky, H. (1996). Local cerebral glucose metabolism in patients with long-term behavioral and cognitive deficits following mild traumatic brain injury. J Neuropsychiatry Clin Neurosci, 8(3), 324-334.
23. Haseler, L. J., Arcinue, E., Danielsen, E. R., Bluml, S., & Ross, B. D. (1997). Evidence from proton magnetic resonance spectroscopy for a metabolic cascade of neuronal damage in shaken baby syndrome. Pediatrics, 99(1), 4-14.
24. Hashimoto, K., & Abo, M. (2009). Abnormal regional benzodiazepine receptor uptake in the prefrontal cortex in patients with mild traumatic brain injury. J Rehabil Med, 41(8), 661-665.
25. Hattori, N., Swan, M., Stobbe, G. A., Uomoto, J. M., Minoshima, S., Djang, D., et al. (2009). Differential SPECT activation patterns associated with PASAT performance may indicate frontocerebellar functional dissociation in chronic mild traumatic brain injury. J Nucl Med, 50(7), 1054-1061.
26. Henry, L., Tremblay, S., Leclerc, S., Khiat, A., Boulanger, Y., Ellemberg, D., et al. (2011). Metabolic changes in concussed American football players during the acute and chronic post-injury phases. BMC Neurol, 11, 105. doi: 10. 1186/1471-2377-11-105.
27. Henry, L. C., Tremblay, S. b., Boulanger, Y., Ellemberg, D., & Lassonde, M. (2009). Neurometabolic changes in the acute phase following sports concussions correlate with symptom severity. J Neurotrauma, 0(ja), doi: 10. 1089/neu. 2009. 0962.
28. Hofman, P. A., Stapert, S. Z., van Kroonenburgh, M. J., Jolles, J., de Kruijk, J., & Wilmink, J. T. (2001). MR imaging, single-photon emission CT, and neurocognitive performance after mild traumatic brain injury. AJNR Am J Neuroradiol, 22(3), 441-449.
29. Holshouser, B. A., Tong, K. A., & Ashwal, S. (2005). Proton MR spectroscopic imaging depicts diffuse axonal injury in children with traumatic brain injury. AJNR Am J Neuroradiol, 26(5), 1276-1285.
30. Humayun, M. S., Presty, S. K., Lafrance, N. D., Holcomb, H. H., Loats, H., Long, D. M., et al. (1989). Local cerebral glucose abnormalities in mild closed head injured patients with cognitive impairments. Nucl Med Commun, 10(5), 335-344.
31. Ichise, M., Chung, D. G., Wang, P., Wortzman, G., Gray, B. G., & Franks, W. (1994). Technetium-99 m-HMPAO SPECT, CT and MRI in the evaluation of patients with chronic traumatic brain injury: a correlation with neuropsychological performance. J Nucl Med, 35(2), 217-226.
32. Iverson, G. L., Gaetz, M., Lovell, M. R., & Collins, M. W. (2004). Cumulative effects of concussion in amateur athletes. Brain Inj, 18(5), 433-443.
33. Jacobs, A., Put, E., Ingels, M., Put, T., & Bossuyt, A. (1996). One-year follow-up of technetium-99 m-HMPAO SPECT in mild head injury. J Nucl Med, 37(10), 1605-1609.
34. Kant, R., Smith-Seemiller, L., Isaac, G., & Duffy, J. (1997). Tc-HMPAO SPECT in persistent post-concussion syndrome after mild head injury: comparison with MRI/CT. Brain Inj, 11(2), 115-124.
35. Kirov, I., Fleysher, L., Babb, J. S., Silver, J. M., Grossman, R. I., & Gonen, O. (2007). Characterizing 'mild' in traumatic brain injury with proton MR spectroscopy in the thalamus: Initial findings. Brain Inj, 21(11), 1147-1154.
36. Kraus, M. F., Susmaras, T., Caughlin, B. P., Walker, C. J., Sweeney, J. A., & Little, D. M. (2007). White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study. Brain, 130(10), 2508-2519.
37. Langlois, J. A., Rutland-Brown, W., & Wald, M. M. (2006). The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil, 21(5), 375-378.
38. Leonard, J. P., Nowotnik, D. P., & Neirinckx, R. D. (1986). Technetium-99 m-d, 1-HM-PAO: a new radiopharmaceutical for imaging regional brain perfusion using SPECT-a comparison with iodine-123 HIPDM. J Nucl Med, 27(12), 1819-1823.
39. Lewine, J. D., Davis, J. T., Bigler, E. D., Thoma, R., Hill, D., Funke, M., et al. (2007). Objective documentation of traumatic brain injury subsequent to mild head trauma: multimodal brain imaging with MEG, SPECT, and MRI. J Head Trauma Rehabil, 22(3), 141-155.
40. Lin, A., Ross, B. D., Harris, K., & Wong, W. (2005). Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making. NeuroRx, 2(2), 197-214.
41. Lin, A. P., Ramadan, S., Box, H., Stanwell, P., & Stern, R. (2010). Neurochemical Changes in Athletes with Chronic Traumatic Encephalopathy. Paper presented at the 96th Scientific Assembly and Annual Meeting of the Radiological Society of North America, Chicago, IL.
42. Lin, A. P., Shic, F., Enriquez, C., & Ross, B. D. (2003). Reduced glutamate neurotransmission in patients with Alzheimer's disease-an in vivo (13)C magnetic resonance spectroscopy study. MAGMA, 16(1), 29-42.
43. Makoroff, K. L., Cecil, K. M., Care, M., & Ball, W. S., Jr. (2005). Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury. Pediatr Radiol, 35(7), 668-676.
44. Maugans, T. A., Farley, C., Altaye, M., Leach, J., & Cecil, K. M. (2012). Pediatric sports-related concussion produces cerebral blood flow alterations. Pediatrics, 129(1), 28-37.
45. McDonald, B. C., Saykin, A. J., & McAllister, T. W. (2012). Functional MRI of mild traumatic brain injury (MTBI): Progress and perspectives from the first decade of studies. Brain Imaging and Behavior.
46. Meehan, W. P., 3rd, & Bachur, R. G. (2009). Sport-related concussion. Pediatrics, 123(1), 114-123.
47. Peskind, E. R., Petrie, E. C., Cross, D. J., Pagulayan, K., McCraw, K., Hoff, D., et al. (2011). Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms. Neuroimage, 54(Suppl 1), S76-82.
48. Provenzano, F. A., Jordan, B., Tikofsky, R. S., Saxena, C., van Heertum, R. L., & Ichise, M. (2010). F-18 FDG PET imaging of chronic traumatic brain injury in boxers: a statistical parametric analysis. Nucl Med Commun, 31(11), 952-957.
49. Roberts, M. A., Manshadi, F. F., Bushnell, D. L., & Hines, M. E. (1995). Neurobehavioural dysfunction following mild traumatic brain injury in childhood: a case report with positive findings on positron emission tomography (PET). Brain Inj, 9(5), 427-436.
50. Ross, B. D., Ernst, T., Kreis, R., Haseler, L. J., Bayer, S., Danielsen, E., et al. (1998). 1H MRS in acute traumatic brain injury. J Magn Reson Imaging, 8(4), 829-840.
51. Ruff, R. M., Crouch, J. A., Troster, A. I., Marshall, L. F., Buchsbaum, M. S., Lottenberg, S., et al. (1994). Selected cases of poor outcome following a minor brain trauma: comparing neuropsychological and positron emission tomography assessment. Brain Inj, 8(4), 297-308.
52. Rushing, S. E., Pryma, D. A., & Langleben, D. D. (2012). PET and SPECT. In Neuroimaging in Forensic Psychiatry (pp. 1-25). John Wiley & Sons, Ltd.
53. Sarmento, E., Moreira, P., Brito, C., Souza, J., Jevoux, C., & Bigal, M. (2009). Proton spectroscopy in patients with post-traumatic headache attributed to mild head injury. Headache, 49(9), 1345-1352.
54. Shenton, M. E., Hamoda, H. M., Schneiderman, J. S., Bouix, S., Pasternak, O., Rathi, Y., et al. (2012). A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging Behav, doi: 10. 1007/s11682-012-9156-5.
55. Shutter, L., Tong, K. A., & Holshouser, B. A. (2004). Proton MRS in acute traumatic brain injury: role for glutamate/glutamine and choline for outcome prediction. J Neurotrauma, 21(12), 1693-1705.
56. Signoretti, S., Marmarou, A., Tavazzi, B., Lazzarino, G., Beaumont, A., & Vagnozzi, R. (2001). N-Acetylaspartate reduction as a measure of injury severity and mitochondrial dysfunction following diffuse traumatic brain injury. J Neurotrauma, 18(10), 977-991.
57. Slobounov, S. M., Gay, M., Johnson, B., & Zhang, K. (2012). Concussion in athletics: ongoing clinician and brain imaging research controversies. Brain Imaging and Behavior.
58. Umile, E. M., Plotkin, R. C., & Sandel, M. E. (1998). Functional assessment of mild traumatic brain injury using SPECT and neuropsychological testing. Brain Inj, 12(7), 577-594.
59. Umile, E. M., Sandel, M. E., Alavi, A., Terry, C. M., & Plotkin, R. C. (2002). Dynamic imaging in mild traumatic brain injury: support for the theory of medial temporal vulnerability. Arch Phys Med Rehabil, 83(11), 1506-1513.
60. Vagnozzi, R., Signoretti, S., Cristofori, L., Alessandrini, F., Floris, R., Isgro, E., et al. (2010). Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients. Brain, 133(11), 3232-3242.
61. Vagnozzi, R., Signoretti, S., Tavazzi, B., Floris, R., Ludovici, A., Marziali, S., et al. (2008). Temporal window of metabolic brain vulnerability to concussion: A pilot 1H-magnetic resonance spectroscopic study in concussed athletes-part III. Neurosurgery, 62(6), 1286-1296.
62. Woods, S. W. (1992). Regional cerebral blood flow imaging with SPECT in psychiatric disease: focus on schizophrenia, anxiety disorders, and substance abuse. J Clin Psychiatry, 53(Suppl), 20-25.
63. Wortzel, H. S., Filley, C. M., Anderson, C. A., Oster, T., & Arciniegas, D. B. (2008). Forensic applications of cerebral single photon emission computed tomography in mild traumatic brain injury. J Am Acad Psychiatry Law, 36(3), 310-322.
64. Yeo, R. A., Gasparovic, C., Merideth, F., Ruhl, D., Doezema, D., & Mayer, A. R. (2011). A longitudinal proton magnetic resonance spectroscopy study of mild traumatic brain injury. J Neurotrauma, 28(1), 1-11.