A prospective, multicenter, randomized, controlled study: The Correction of Metabolic Acidosis with Use of Bicarbonate in Chronic Renal Insufficiency (UBI) Study

Journal of Nephrology

Volumn 25, Issue 3, 2012, Pages 437-440

  Di Iorio, Biagio ^a,b   Aucella, Filippo ^b,c   Conte, Giuseppe ^b,d   Cupisti, Adamasco ^b,e   Santoro, Domenico ^b,f  

^a A Landolfi Hospital   (Italy)

^b Work Group of the Conservative Therapy for Chronic Renal Insufficiency   (Italy)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

^e UNIVERSITY OF PISA   (Italy)

^f UNIVERSITY OF MESSINA   (Italy)

Author keywords

Chronic kidney disease; Metabolic acidosis; Morbility; Mortality

Indexed keywords

BICARBONATE; CREATININE;

ADULT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CHRONIC KIDNEY FAILURE; CLINICAL PROTOCOL; COHORT ANALYSIS; CONTROLLED STUDY; CREATININE CLEARANCE; DISEASE COURSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC ACIDOSIS; MORTALITY; MULTICENTER STUDY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REVIEW;

ACIDOSIS; CARDIOVASCULAR DISEASES; HUMANS; ITALY; KIDNEY FAILURE, CHRONIC; PROSPECTIVE STUDIES; RENAL DIALYSIS; RENAL INSUFFICIENCY, CHRONIC; RESEARCH DESIGN; SODIUM BICARBONATE; TIME FACTORS; TREATMENT OUTCOME;

EID: 84863300339     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.5301/jn.5000014     Document Type: Review

References (14)

1. Roderick P, Willis NS, Blakely S, Jones C, Tompson C. Correction of chronic metabolic acidosis for chronic kidney disease patients. Cochrane Database Syst Rev. 2007; Jan 24(1): CD001890.
2. de Brito-Ashurst I, Varagunam M, Raftery MJ, Yaqoob MM. Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol. 2009;20(9):2075-2084.
3. Ballmer PE, McNurlan MA, Hulter HN, Anderson SE, Garlick PJ, Krapf R. Chronic metabolic acidosis decreases albumin synthesis and induces negative nitrogen balance in humans. J Clin Invest. 1995;95(1):39-45.
4. Mitch WE, Du J, Bailey JL, Price SR. Mechanisms causing muscle proteolysis in uremia: the influence of insulin and cytokines. Miner Electrolyte Metab. 1999;25(4-6):216-219.
5. Löfberg E, Wernerman J, Anderstam B, Bergström J. Correction of acidosis in dialysis patients increases branched-chain and total essential amino acid levels in muscle. Clin Nephrol. 1997;48(4):230-237.
6. Jara A, Felsenfeld AJ, Bover J, Kleeman CR. Chronic metabolic acidosis in azotemic rats on a high-phosphate diet halts the progression of renal disease. Kidney Int. 2000;58(3):1023-1032.
7. Jara A, Chacón C, Ibaceta M, Valdivieso A, Felsenfeld AJ. Effect of ammonium chloride and dietary phosphorus in the azotaemic rat: Part II: kidney hypertrophy and calcium deposition. Nephrol Dial Transplant. 2004;19(8):1993-1998.
8. Chiu YW, Kopple JD, Mehrotra R. Correction of metabolic acidosis to ameliorate wasting in chronic kidney disease: goals and strategies. Semin Nephrol. 2009;29(1):67-74.
9. Bommer J, Locatelli F, Satayatum S, et al. association of predialysis serum bicarbonate levels with risk of mortality and hospitalization in the DOPPS. Am J Kidney Dis. 2004;44:661-671.
10. Wu DY, Shinaberger CS, Regidor DL, McAllister CJ, Kopple JD, Kalantar-Zadeh K. Association between serum bicarbonate and death in hemodialysis patients: is it better to be acidotic or alkalotic? Clin J Am Soc Nephrol. 2006;1(1):70-78.
11. Menon V, Tighiouart H, Vaughn NS, et al. Serum bicarbonate and long-term outcomes in CKD. Am J Kidney Dis. 2010;56(5):907-914.
12. Kraut JA, Madias NE. Metabolic acidosis: pathophysiology, diagnosis and management. Nat Rev Nephrol. 2010;6:274-85.
13. Wesson DE, Simoni J. Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet. Kidney Int. 2010;78(11):1128-1135.
14. Sahni V, Rosa RM, Batlle D. Potential benefits of alkali therapy to prevent GFR loss: time for a palatable 'solution' for the management of CKD. Kidney Int. 2010;78(11):1065-1067.