Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope

Arthritis and Rheumatism

Volumn 64, Issue 3, 2012, Pages 925-930

  Prahalad, Sampath ^a   Thompson, Susan D ^b   Conneely, Karen N ^b,h   Jiang, Yunxuan ^a   Leong, Traci ^a   Prozonic, Jennifer ^a   Brown, Milton R ^a   Ponder, Lori A ^a   Angeles Han, Sheila T ^a   Vogler, Larry B ^a   Kennedy, Christine ^a   Wallace, Carol A ^c   Wise, Carol A ^d   Punaro, Marilynn ^d   Reed, Ann ^e   Park, Jane L ^f   Mellins, Elizabeth D ^f   Zeft, Andrew S ^g   Bohnsack, John F ^g   Glass, David N ^b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d TEXAS SCOTTISH RITE HOSPITAL FOR CHILDREN   (United States)

^e MAYO CLINIC   (United States)

^f STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^g UNIVERSITY OF UTAH   (United States)

^h EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA DRB1 ANTIGEN; RHEUMATOID FACTOR;

ADULT; ALLELE; AMINO ACID SEQUENCE; ARTICLE; CHILD; CHILDHOOD DISEASE; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN TISSUE; IDIOPATHIC DISEASE; JUVENILE RHEUMATOID ARTHRITIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHOOL CHILD;

AGE OF ONSET; ALLELES; ARTHRITIS, JUVENILE RHEUMATOID; CHILD; GENETIC PREDISPOSITION TO DISEASE; GEORGIA; HLA-DRB1 CHAINS; HUMANS; IMMUNODOMINANT EPITOPES; RISK FACTORS;

EID: 84863294946     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.33376     Document Type: Article

References (20)

1. Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet 2010; 42: 508-14.
2. Gregersen PK, Silver J, Winchester RJ,. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30: 1205-13.
3. Fernando MM, Stevens CR, Walsh EC, De Jager PL, Goyette P, Plenge RM, et al. Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet 2008; 4: e1000024.
4. Du Montcel ST, Michou L, Petit-Teixeira E, Osorio J, Lemaire I, Lasbleiz S, et al. New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility. Arthritis Rheum 2005; 52: 1063-8.
5. Michou L, Croiseau P, Petit-Teixeira E, du Montcel ST, Lemaire I, Pierlot C, et al. Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis. Arthritis Res Ther 2006; 8: R79.
6. Barron KS, Silverman ED, Gonzales JC, Owerbach D, Reveille JD,. DNA analysis of HLA-DR, DQ, and DP alleles in children with polyarticular juvenile rheumatoid arthritis. J Rheumatol 1992; 19: 1611-6.
7. Clemens LE, Albert E, Ansell BM,. HLA studies in IgM rheumatoid-factor- positive arthritis of childhood. Ann Rheum Dis 1983; 42: 431-4.
8. Forre O, Dobloug JH, Hoyeraal HM, Thorsby E,. HLA antigens in juvenile arthritis: genetic basis for the different subtypes. Arthritis Rheum 1983; 26: 35-8.
9. Nepom BS, Nepom GT, Mickelson E, Schaller JG, Antonelli P, Hansen JA,. Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropositive juvenile rheumatoid arthritis. J Clin Invest 1984; 74: 287-91.
10. Thomson W, Barrett JH, Donn R, Pepper L, Kennedy LJ, Ollier WE, et al. Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients. Rheumatology (Oxford) 2002; 41: 1183-9.
11. Vehe RK, Begovich AB, Nepom BS,. HLA susceptibility genes in rheumatoid factor positive juvenile rheumatoid arthritis. J Rheumatol Suppl 1990; 26: 11-5.
12. Bridges SL Jr, Kelley JM, Hughes LB,. The HLA-DRB1 shared epitope in Caucasians with rheumatoid arthritis: a lesson learned from tic-tac-toe [editorial]. Arthritis Rheum 2008; 58: 1211-5.
13. Maiers M, Gragert L, Klitz W,. High-resolution HLA alleles and haplotypes in the United States population. Hum Immunol 2007; 68: 779-88.
14. Morgan AW, Haroon-Rashid L, Martin SG, Gooi HC, Worthington J, Thomson W, et al. The shared epitope hypothesis in rheumatoid arthritis: evaluation of alternative classification criteria in a large UK Caucasian cohort. Arthritis Rheum 2008; 58: 1275-83.
15. Kallberg H, Padyukov L, Plenge RM, Ronnelid J, Gregersen PK, van der Helm-van Mil AH, et al, for the Epidemiological Investigation of Rheumatoid Arthritis Study Group. Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. Am J Hum Genet 2007; 80: 867-75.
16. Wordsworth P, Pile KD, Buckely JD, Lanchbury JS, Ollier B, Lathrop M, et al. HLA heterozygosity contributes to susceptibility to rheumatoid arthritis. Am J Hum Genet 1992; 51: 585-91.
17. Hughes LB, Morrison D, Kelley JM, Padilla MA, Vaughan LK, Westfall AO, et al. The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture. Arthritis Rheum 2008; 58: 349-58.
18. Bochukova EG, Huang N, Keogh J, Henning E, Purmann C, Blaszczyk K, et al. Large, rare chromosomal deletions associated with severe early-onset obesity. Nature 2010; 463: 666-70.
19. Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, et al. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet 2009; 41: 1335-40.
20. Klareskog L, Stolt P, Lundberg K, Kallberg H, Bengtsson C, Grunewald J, et al, and the Epidemiological Investigation of Rheumatoid Arthritis Study Group. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006; 54: 38-46.