The HLA-DRB1 shared epitope in Caucasians with rheumatoid arthritis: A lesson learned from tic-tac-toe

Arthritis and Rheumatism

Volumn 58, Issue 5, 2008, Pages 1211-1215

  Bridges Jr , S Louis ^a,b   Kelley, James M ^a   Hughes, Laura B ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ARGININE; ASPARTIC ACID; EPITOPE; HLA DR ANTIGEN;

ALLELE; CAUCASIAN; DISEASE PREDISPOSITION; DISEASE SEVERITY; EDITORIAL; GENE LOCUS; HOMOZYGOTE; PATHOGENESIS; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN MOTIF; REPRODUCIBILITY; RHEUMATOID ARTHRITIS;

ARTHRITIS, RHEUMATOID; EPITOPES; EUROPEAN CONTINENTAL ANCESTRY GROUP; HLA-DR ANTIGENS; HUMANS;

EID: 43949124836     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.23433     Document Type: Editorial

References (21)

1. Stastny P. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med 1978;298:869-71.
2. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30: 1205-13.
3. Ronningen KS, Spurkland A, Egeland T, Iwe T, Munthe E, Vartdal F, et al. Rheumatoid arthritis may be primarily associated with HLA-DR4 molecules sharing a particular sequence at residues 67-74. Tissue Antigens 1990;36:235-40.
4. Weyand CM, Hicok KC, Conn DL, Goronzy JJ. The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Intern Med 1992;117:801-6.
5. O'Dell JR, Nepom BS, Haire C, Gersuk VH, Gaur L, Moore GF, et al. HLA-DRB1 typing in rheumatoid arthritis: predicting response to specific treatments. Ann Rheum Dis 1998;57:209-13.
6. Criswell LA, Lum RF, Turner KN, Wochl B, Zhu Y, Wang J, et al. The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. Arthritis Rheum 2004;50:2750-6.
7. Morgan AW, Haroon-Rashid L, Martin SG, Gooi HC, Worthington J, Thomson W, et al. The shared epitope hypothesis in rheumatoid arthritis: evaluation of alternative classification criteria in a large UK Caucasian cohort. Arthritis Rheum 2008;58: 1275-83.
8. Tezenas du Montcel S, Michou L, Petit-Teixeira E, Osorio J, Lemaire I, Lasbleiz S, et al. New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility. Arthritis Rheum 2005;52:1063-8.
9. De Vries N, Tijssen H, van Riel PL, van de Putte LB. Reshaping the shared epitope hypothesis: HLA-associated risk for rheumatoid arthritis is encoded by amino acid substitutions at positions 67-74 of the HLA-DRB1 molecule. Arthritis Rheum 2002;46: 921-8.
10. Mattey DL, Dawes PT, Gonzalez-Gay MA, Garcia-Porrua C, Thomson W, Hajeer AH, et al. HLA-DRB1 alleles encoding an aspartic acid at position 70 protect against development of rheumatoid arthritis. J Rheumatol 2001;28:232-9.
11. Larsen BA, Alderdice CA, Hawkins D, Martin JR, Mitchell DM, Sheridan DP. Protective HLA-DR phenotypes in rheumatoid arthritis. J Rheumatol 1989;16:455-8.
12. Wakitani S, Murata N, Toda Y, Ogawa R, Kaneshige T, Nishimura Y, et al. The relationship between HLA-DRB1 alleles and disease subsets of rheumatoid arthritis in Japanese. Br J Rheumatol 1997;36:630-6.
13. Reviron D, Perdriger A, Toussirot E, Wendling D, Balandraud N, Guis S, et al. Influence of shared epitope-negative HLA-DRB1 alleles on genetic susceptibility to rheumatoid arthritis. Arthritis Rheum 2001;44:535-40.
14. Hughes LB, Morrison D, Kelley JM, Padilla MA, Vaughan LK, Westfall AO, et al. The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture. Arthritis Rheum 2008;58: 349-58.
15. Michou L, Croiseau P, Petit-Teixeira E, Tezenas du Montcel S, Lemaire I, Pierlot C, et al, for the European Consortium on Rheumatoid Arthritis Families. Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis. Arthritis Res Ther 2006;8:R79.
16. Winchester R. Reshaping Cinderella's slipper: the shared epitope hypothesis. Arthritis Res Ther 2006;8:109.
17. Von Neumann J, Morgenstern O. Theory of games and economic behavior. Princeton (NJ): Princeton University Press; 1944.
18. Spangler B. Positive-sum, zero-sum, and negative-sum situations. In: Burgess G, Burgess H, editors. Beyond intractability. Conflict Research Consortium, University of Colorado, Boulder; 2003. URL: http://www. beyondintractability.org/essay/sum/.
19. Klareskog L, Stolt P, Lundberg K, Kaliberg H, Bengtsson C, Grunewald J, et al, and the Epidemiological Investigation of Rheumatoid Arthritis Study Group. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006;54:38-46.
20. Gulko P, Winchester R. Rheumatoid arthritis. In: Austen KF, Frank MM, Atkinson JP, Cantor H, editors. Samter's immunologic diseases. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 427-62.
21. Brown JH, Jardetzky TS, Gorga JC, Stern LJ, Urban RG, Strominger JL, et al. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 1993;364:33-9.