A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives

Chemistry - A European Journal

Volumn 18, Issue 11, 2012, Pages 3193-3198

  Zheng, Shaojun ^a,c   Aves, Sarah J ^a   Laraia, Luca ^a   Galloway, Warren R J D ^a   Pike, Kurt G ^b   Wu, Wenjun ^c   Spring, David R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c NORTHWEST A F UNIVERSITY   (China)

Author keywords

antitumor agents; C C coupling; copper; medium ring compounds; natural products

Indexed keywords

ANTI-TUMOR AGENTS; ANTICANCER ACTIVITIES; ANTIPROLIFERATIVE EFFECT; BIOLOGICAL STUDIES; C-C COUPLING; HUMAN CANCER CELLS; IN-VITRO; MEDIUM RINGS; MEDIUM-RING COMPOUNDS; NATURAL PRODUCTS; ORGANOCUPRATE; SYNTHETIC PRECURSORS; THERAPEUTIC POTENTIALS; TOTAL SYNTHESIS;

CHEMISTRY; COPPER; SYNTHESIS (CHEMICAL);

CELL CULTURE;

ANTINEOPLASTIC AGENT; CYCLOOCTANE DERIVATIVE; LIGNAN; POLYCYCLIC HYDROCARBON; SCHIZANDRIN A;

ARTICLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; HUMAN; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLOOCTANES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIGNANS; MOLECULAR STRUCTURE; POLYCYCLIC COMPOUNDS;

EID: 84863275069     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201103530     Document Type: Article

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