Pilot study of the association of the DDAH2-449G polymorphism with asymmetric dimethylarginine and hemodynamic shock in pediatric sepsis

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Weiss, Scott L ^a   Yu, Min ^a   Jennings, Lawrence ^a   Haymond, Shannon ^a   Zhang, Gang ^b   Wainwright, Mark S ^a  

^a CHILDREN'S MEMORIAL HOSPITAL   (United States)

^b Children's Memorial Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; GUANOSINE; N(G),N(G) DIMETHYLARGININE; AMIDASE; ARGININE; DIMETHYLARGININASE; DRUG DERIVATIVE; N,N DIMETHYLARGININE; N,N-DIMETHYLARGININE; NITRIC OXIDE; PRIMER DNA;

ALLELE; ARTICLE; CHILD; CLINICAL ASSESSMENT; COLD SHOCK RESPONSE; CONTROLLED STUDY; DDAH2 GENE; DISEASE SEVERITY; FEMALE; GENE; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HEMODYNAMICS; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PEDIATRIC SEPSIS; PHENOTYPIC VARIATION; PILOT STUDY; PROSPECTIVE STUDY; SCHOOL CHILD; SEPSIS; SEPTIC SHOCK; SINGLE NUCLEOTIDE POLYMORPHISM; TANDEM MASS SPECTROMETRY; ADOLESCENT; BLOOD; DNA SEQUENCE; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; RACE; SEX DIFFERENCE;

ADOLESCENT; AMIDOHYDROLASES; ARGININE; BASE SEQUENCE; CHILD; CONTINENTAL POPULATION GROUPS; DNA PRIMERS; GENETIC ASSOCIATION STUDIES; GENOTYPE; HEMODYNAMICS; HUMANS; MOLECULAR SEQUENCE DATA; NITRIC OXIDE; PILOT PROJECTS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; SEQUENCE ANALYSIS, DNA; SEX FACTORS; SHOCK, SEPTIC; TANDEM MASS SPECTROMETRY;

EID: 84863274678     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033355     Document Type: Article

References (44)

1. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, et al. (2008) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 36: 296-327.
2. Ceneviva G, Paschall JA, Maffei F, Carcillo JA, (1998) Hemodynamic support in fluid-refractory pediatric septic shock. Pediatrics 102: e19.
3. Parker MM, Shelhamer JH, Natanson C, Alling DW, Parrillo JE, (1987) Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: heart rate as an early predictor of prognosis. Crit Care Med 15: 923-929.
4. Pollack MM, Fields AI, Ruttimann UE, (1985) Distributions of cardiopulmonary variables in pediatric survivors and nonsurvivors of septic shock. Crit Care Med 13: 454-459.
5. Vincent JL, Zhang H, Szabo C, Preiser JC, (2000) Effects of nitric oxide in septic shock. Am J Respir Crit Care Med 161: 1781-1785.
6. de Werra I, Jaccard C, Corradin SB, Chiolero R, Yersin B, et al. (1997) Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations: comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia. Crit Care Med 25: 607-613.
7. Krafte-Jacobs B, Brilli R, Szabo C, Denenberg A, Moore L, et al. (1997) Circulating methemoglobin and nitrite/nitrate concentrations as indicators of nitric oxide overproduction in critically ill children with septic shock. Crit Care Med 25: 1588-1593.
8. Wong HR, Carcillo JA, Burckart G, Shah N, Janosky JE, (1995) Increased serum nitrite and nitrate concentrations in children with the sepsis syndrome. Crit Care Med 23: 835-842.
9. Argaman Z, Young VR, Noviski N, Castillo-Rosas L, Lu XM, et al. (2003) Arginine and nitric oxide metabolism in critically ill septic pediatric patients. Crit Care Med 31: 591-597.
10. Tran CT, Leiper JM, Vallance P, (2003) The DDAH/ADMA/NOS pathway. Atheroscler Suppl 4 pp. 33-40.
11. O'Dwyer MJ, Dempsey F, Crowley V, Kelleher DP, McManus R, et al. (2006) Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study. Crit Care 10: R139.
12. Nijveldt RJ, Teerlink T, Van Der Hoven B, Siroen MP, Kuik DJ, et al. (2003) Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality. Clin Nutr 22: 23-30.
13. Yeo TW, Lampah DA, Tjitra E, Gitawati R, Darcy CJ, et al. (2010) Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome. PLoS Pathog 6: e1000868.
14. Boger RH, Maas R, Schulze F, Schwedhelm E, (2005) Elevated levels of asymmetric dimethylarginine (ADMA) as a marker of cardiovascular disease and mortality. Clin Chem Lab Med 43: 1124-1129.
15. Schulze F, Lenzen H, Hanefeld C, Bartling A, Osterziel KJ, et al. (2006) Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study. Am Heart J 152: 493 e491-498.
16. Brooks ER, Langman CB, Wang S, Price HE, Hodges AL, et al. (2009) Methylated arginine derivatives in children and adolescents with chronic kidney disease. Pediatr Nephrol 24: 129-134.
17. Weiss S, Haymond SH, Ralay-Ranaivo H, Wang D, De Jesus VR, et al. (2012) Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis. Critical Care Medicine In press.
18. Abhary S, Burdon KP, Kuot A, Javadiyan S, Whiting MJ, et al. (2010) Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes. PLoS One 5: e9462.
19. Akbar F, Heinonen S, Pirskanen M, Uimari P, Tuomainen TP, et al. (2005) Haplotypic association of DDAH1 with susceptibility to pre-eclampsia. Mol Hum Reprod 11: 73-77.
20. Palm F, Onozato ML, Luo Z, Wilcox CS, (2007) Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems. Am J Physiol Heart Circ Physiol 293: H3227-3245.
21. Ryan R, Thornton J, Duggan E, McGovern E, O'Dwyer MJ, et al. (2006) Gene polymorphism and requirement for vasopressor infusion after cardiac surgery. Ann Thorac Surg 82: 895-901.
22. Goldstein B, Giroir B, Randolph A, (2005) International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 6: 2-8.
23. Slater A, Shann F, Pearson G, (2003) PIM2: a revised version of the Paediatric Index of Mortality. Intensive Care Med 29: 278-285.
24. Leteurtre S, Martinot A, Duhamel A, Proulx F, Grandbastien B, et al. (2003) Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet 362: 192-197.
25. Gaies MG, Gurney JG, Yen AH, Napoli ML, Gajarski RJ, et al. (2010) Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med 11: 234-238.
26. Brierley J, Carcillo JA, Choong K, Cornell T, Decaen A, et al. (2009) Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit Care Med 37: 666-688.
27. Wang S, Vicente FB, Miller A, Brooks ER, Price HE, et al. (2007) Measurement of arginine derivatives in pediatric patients with chronic kidney disease using high-performance liquid chromatography-tandem mass spectrometry. Clin Chem Lab Med 45: 1305-1312.
28. Jones LC, Tran CT, Leiper JM, Hingorani AD, Vallance P, (2003) Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells. Biochem Biophys Res Commun 310: 836-843.
29. Bai Y, Chen J, Sun K, Xin Y, Liu J, et al. (2009) Common genetic variation in DDAH2 is associated with intracerebral haemorrhage in a Chinese population: a multi-centre case-control study in China. Clin Sci (Lond) 117: 273-279.
30. Maas R, Erdmann J, Luneburg N, Stritzke J, Schwedhelm E, et al. (2009) Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertension. Pharmacol Res 60: 488-493.
31. Brierley J, Peters MJ, (2008) Distinct hemodynamic patterns of septic shock at presentation to pediatric intensive care. Pediatrics 122: 752-759.
32. Valkonen VP, Tuomainen TP, Laaksonen R, (2005) DDAH gene and cardiovascular risk. Vasc Med 10 (Suppl 1): S45-48.
33. Iapichino G, Umbrello M, Albicini M, Spanu P, Bellani G, et al. (2010) Time course of endogenous nitric oxide inhibitors in severe sepsis in humans. Minerva Anestesiol 76: 325-333.
34. Davis JS, Darcy CJ, Yeo TW, Jones C, McNeil YR, et al. (2011) Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis. PLoS One 6: e17260.
35. Dayoub H, Achan V, Adimoolam S, Jacobi J, Stuehlinger MC, et al. (2003) Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence. Circulation 108: 3042-3047.
36. Lu CW, Xiong Y, He P, (2007) Dimethylarginine dimethylaminohydrolase-2 overexpression improves impaired nitric oxide synthesis of endothelial cells induced by glycated protein. Nitric Oxide 16: 94-103.
37. MacAllister RJ, Parry H, Kimoto M, Ogawa T, Russell RJ, et al. (1996) Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase. Br J Pharmacol 119: 1533-1540.
38. Chan JR, Boger RH, Bode-Boger SM, Tangphao O, Tsao PS, et al. (2000) Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans. Arterioscler Thromb Vasc Biol 20: 1040-1046.
39. Wang D, Gill PS, Chabrashvili T, Onozato ML, Raggio J, et al. (2007) Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO. Circ Res 101: 627-635.
40. Hu X, Atzler D, Xu X, Zhang P, Guo H, et al. (2011) Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arterioscler Thromb Vasc Biol 31: 1540-1546.
41. Wang J, Sim AS, Wang XL, Wilcken DE, (2006) L-arginine regulates asymmetric dimethylarginine metabolism by inhibiting dimethylarginine dimethylaminohydrolase activity in hepatic (HepG2) cells. Cell Mol Life Sci 63: 2838-2846.
42. Leiper J, Murray-Rust J, McDonald N, Vallance P, (2002) S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase. Proc Natl Acad Sci U S A 99: 13527-13532.
43. Lander ES, Schork NJ, (1994) Genetic dissection of complex traits. Science 265: 2037-2048.
44. Wilcken DE, Sim AS, Wang J, Wang XL, (2007) Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of L-arginine on its metabolism. Mol Genet Metab 91: 309-317; discussion 308.