Circulating methemoglobin and nitrite/nitrate concentrations as indicators of nitric oxide overproduction in critically ill children with septic shock

Critical Care Medicine

Volumn 25, Issue 9, 1997, Pages 1588-1593

  Krafte Jacobs, Brian ^a   Brilli, Richard ^a   Szabó, Csaba ^a   Denenberg, Alvin ^a   Moore, Lori ^a   Salzman, Andrew L ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Children; Critical care; Methemoglobin; Nitrate; Nitric oxide; Nitrite; Sepsis; Septic shock

Indexed keywords

CREATININE; METHEMOGLOBIN; NITRATE; NITRIC OXIDE; NITRITE;

ARTERIAL PH; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CRITICAL ILLNESS; FEMALE; HUMAN; HYPOTENSION; MALE; OXIMETRY; PRIORITY JOURNAL; SEPTIC SHOCK; SPECTROPHOTOMETRY; URINE VOLUME;

ADOLESCENT; BIOLOGICAL MARKERS; BLOOD GAS ANALYSIS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; INFANT; LINEAR MODELS; MALE; METHEMOGLOBINEMIA; NITRATES; NITRIC OXIDE; NITRITES; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC; SURVIVAL ANALYSIS;

EID: 0030770645     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199709000-00030     Document Type: Article

References (42)

1. Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43:109-142
2. Szabó C, Thiemermann C: Role of nitric oxide in haemorrhagic, traumatic and anaphylactic shock and in thermal injury. Shock 1994; 2:145-155
3. Kilbourn RG, Belloni P: Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin. J Natl Cancer Inst 1990; 82:772-776
4. Stuehr DJ, Nathan CF: Nitric oxide: A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med 1989; 169:1543-1555
5. Nathan C: Nitric oxide as a secretory product of mammalian cells. FASEB J 1992; 6:3051-3064
6. Kilbourn RG, Griffith OW: Overproduction of nitric oxide in cytokine mediated and septic shock. J Natl Cancer Inst 1992; 84:827-831
7. Gomez-Jimenez J, Salgado A, Mourelle M, et al: L-arginine: Nitric oxide pathway in endotoxemia and human septic shock. Crit Care Med 1995; 23:253-258
8. Stuehr DJ, Marietta MA: Mammalian nitrate biosynthesis: Mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc Natl Acad Sci U S A 1985; 82:7738-7742
9. Szabó C: Alterations in nitric oxide production in various forms of circulatory shock. New Horiz 1995; 3:2-32
10. Petros A, Bennett D, Vallance P: Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 1991; 338:1557-1558
11. Geroulanos S, Schilling J, Cakmakci M, et al: Inhibition of NO synthesis in septic shock. Lancet 1992; 339:435
12. G-methyl-L-arginine, an inhibitor of nitric oxide formation, acts synergistically with dobutamine to improve cardiovascular performance in endotoxemic dogs. Crit Care Med 1994; 22:1835-1840
13. Southan GJ, Szabó C: Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem Pharmacol 1996; 51:383-394
14. Szabó C, Southan GJ, Thiemermann C: Beneficial effects and improved survival in rodent models of septic shock with S-methyl-isothiourea sulfate, a novel, potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci U S A 1994; 91:12472-12476
15. Ochoa JB, Curti B, Peitzman AB, et al: Increased circulating nitrogen oxides after human tumor immunotherapy: Correlation with toxic hemodynamic changes. J Natl Cancer Inst 1992; 84:864-867
16. Shi Y, Li H, Shen C, et al: Plasma nitric oxide levels in newborn infants with sepsis. J Pediatr 1993; 123: 435-438
17. Wong HR, Carcillo JA, Burckart G, et al: Increased serum nitrite and nitrate concentrations in children with the sepsis syndrome. Crit Care Med 1995; 23:835-842
18. Castillo L: Sources of nitrates and nitrites in neonates with sepsis. J Pediatr 1994; 124:488
19. Sharma VS, Isaacson RA, John ME, et al: Reaction of nitric oxide with heme proteins: Studies on metmyoglobin, opossum methemoglobin and microperoxidase. Biochemistry 1983; 22: 3897-3902
20. Wennmalm A, Benthin G, Patersson AS: Dependence of the metabolism of nitric oxide in healthy human whole blood on the oxygenation of its red cell hemoglobin. Br J Pharmacol 1992; 106: 507-508
21. Wennmalm A, Benthin G, Edlund A, et al: Metabolism and excretion of nitric oxide in humans. An experimental and clinical study. Circ Res 1993; 73: 1121-1127
22. Mansouri A, Lurie AA: Concise review: Methemoglobinemia. Am J Hematol 1993; 42:7-12
23. Hayden WR: Sepsis terminology in pediatrics. J Pediatr 1994; 124:657-658
24. Pollack MM, Ruttimann UE, Getson PR: Pediatric risk of mortality (PRISM) score. Crit Care Med 1988; 16: 1110-1116
25. 15N] nitrate in biological fluids. Anal Biochem 1982; 126:131-138
26. Zingarelli B, Salzman AL, Szabó C: Protective effects of nicotinamide against nitric oxide-mediated delayed vascular failure in endotoxic shock: Potential involvement of polyADP ribosyl synthetase. Shock 1996; 5:258-264
27. Wong HR, Carcillo JA, Burckart G, et al: Nitric oxide production in critically ill patients. Arch Dis Child 1996; 74: 482-489
28. Shah NS, Nakayama DK, Jacob TD, et al: Efficacy of inhaled nitric oxide in a porcine model of adult respiratory distress syndrome. Arch Surg 1994; 129:158-164
29. Spack L, Havens PL, Griffith OW: Measurements of total plasma nitrite and nitrate in pediatric patients with the systemic inflammatory response syndrome. Crit Care Med 1997; 25: 1071-1078
30. Preiser JC, Reper P, Vlasselaer D, et al: Nitric oxide production is increased in patients after burn injury. J Trauma 1996; 40:368-371
31. Ochoa AC, Udekwu AO, Billiar TR, et al: Nitrogen oxide levels in patients following trauma and during sepsis. Ann Surg 1991; 214:621-626
32. Doughty LA, Kaplan SS, Carcillo JA: Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure. Crit Care Med 1996; 24: 1137-1143
33. Stamler JS, Jaraki O, Osborne J, et al: Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci U S A 1992; 89:7674-7677
34. Scharfstein JS, Keaney JF Jr, Slivka A, et al: In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols. J Clin Invest 1994; 94:1432-1439
35. Jia L, Bonaventura J, Stamler JS: S-nitrosohaemoglobin: A dynamic activity of blood involved in vascular control. Nature 1996; 380:221-226
36. Szabó C, Salzman AL, Ischiropoulos H: Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo. FEBS Lett 1995; 363: 235-238
37. Szabó C: The role of peroxynitrite in the pathophysiology of shock, inflammation and ischemia-reperfusion injury. Shock 1996; 6:79-88
38. Moro MA, Darley-Usmar VM, Goodwin DA, et al: Paradoxical fate and biological action of peroxynitrite on human platelets. Proc Natl Acad Sci U S A 1994; 91:6702-6706
39. Krejcy K, Schmetterer L, Kastner J, et al: Role of nitric oxide in hemostatic system activation in humans. Arterioscler Thromb Vasc Biol 1995; 15:2063-2067
40. Henry JB: Whole blood, serum, and plasma chemistry. In: Clinical Diagnosis and Management by Laboratory Methods. Philadelphia, WB Saunders, 1996, Table A4-4
41. Pollack MM, Fields AI, Ruttimann UE: Distributions of cardiopulmonary variables in pediatric survivors and nonsurvivors of septic shock. Crit Care Med 1985; 13:454-459
42. Pollack MM, Fields AI, Ruttimann UE: Sequential cardiopulmonary variables of infants and children in septic shock. Crit Care Med 1984; 12:554-559