Desmethyl macrolides: Synthesis and evaluation of 4,10-didesmethyl telithromycin

ACS Medicinal Chemistry Letters

Volumn 3, Issue 3, 2012, Pages 211-215

  Velvadapu, Venkata ^a   Glassford, Ian ^a   Lee, Miseon ^a   Paul, Tapas ^a   Debrosse, Charles ^a   Klepacki, Dorota ^b   Small, Meagan C ^c   MacKerell, Alexander D ^c   Andrade, Rodrigo B ^a  

^a Temple University   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

antibiotic resistance; desmethyl analogues; ketolide antibiotics; molecular modeling; telithromycin; total synthesis

Indexed keywords

4,10 DIDESMETHYL TELITHROMYCIN; 4,8,10 TRIDESMETHYL TELITHROMYCIN; CARBON; DRUG ANALOG; ERYTHROMYCIN; METHYL GROUP; TELITHROMYCIN; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG APPROVAL; DRUG POTENCY; DRUG SYNTHESIS; FOOD AND DRUG ADMINISTRATION; METHYLATION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL;

BACTERIA (MICROORGANISMS);

EID: 84863267800     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200254h     Document Type: Article

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