Biochemical and reproductive effects of gestational/lactational exposure to lead and cadmium with respect to testicular steroidogenesis, antioxidant system, endogenous sex steroid and cauda-epididymal functions

Andrologia

Volumn 44, Issue 2, 2012, Pages 92-101

  Pillai, P ^a   Pandya, C ^a   Bhatt, N ^a   Gupta, S S ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

Antioxidant system; Cadmium; Gestational lactational exposure; Lead; Sperm count

Indexed keywords

ACETIC ACID; ANTIOXIDANT; ASCORBIC ACID; CADMIUM ACETATE; CATALASE; CHOLESTEROL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LEAD ACETATE; SUPEROXIDE DISMUTASE; TESTOSTERONE 17BETA DEHYDROGENASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DECAPITATION; EPIDIDYMIS TAIL; FEMALE; GESTATION PERIOD; LACTATION; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PRENATAL EXPOSURE; RAT; REPRODUCTION; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; STEROIDOGENESIS; TESTOSTERONE BLOOD LEVEL;

17-HYDROXYSTEROID DEHYDROGENASES; ACETATES; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CADMIUM; CATALASE; CELL SURVIVAL; EPIDIDYMIS; FEMALE; LACTATION; LEAD; LIPID PEROXIDATION; MALE; ORGANOMETALLIC COMPOUNDS; PREGNANCY; RATS; REPRODUCTION; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; STEROIDS; SUPEROXIDE DISMUTASE; TESTIS; TESTOSTERONE;

EID: 84863260468     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2010.01109.x     Document Type: Article

References (59)

1. Agarwal A, Saleh RA (2002) Role of oxidants in male infertility: rationale, significance, and treatment. Urol Clin North Am 29:817-827.
2. Aitken RJ (1999) The Amoroso lecture. The human spermatozoa-a cell in crisis. J Reprod Fertil 115:1-7.
3. Aitken RJ, Gordon E, Harkiss D, Twigg JP, Milne P, Jennings Z, Irvine DS (1998) Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa. Biol Reprod 59:1037-1046.
4. Baker MA, Aitken RJ (2004) The importance of redox regulated pathways in sperm cell biology. Mol Cell Endocrinol 15:47-54.
5. Benoff S, Auborn K, Marmar JL, Hurley IR (2008) Link between low-dose environmentally relevant cadmium exposures and asthenozoospermia in a rat model. Fertil Steril 89:73-79.
6. Beutler E, Gelbart T (1985) Plasma glutathione in health and in patients with malignant disease. J Lab Clin Med 105:581-584.
7. Bowers GN Jr, McComb RB (1975) Measurement of total alkaline phosphatase activity in human serum. Clin Chem 21:1988-1995.
8. Casalino E, Sblano C, Clemente L (1997) Enzyme activity alteration by cadmium administration to rats: the possibility of iron involvement in lipid peroxidation. Arch Biochem Biophys 346:171-179.
9. Chowdhury AR, Dewan A, Gandhi DN (1984) Toxic effect of lead on the testes of rat. Biomed Biochim Acta 43:95-100.
10. Colborn T, Clement C (eds) (1992) Chemically-induced alterations in sexual and functional development: the wildlife/human connection. Advances in Modern Environ Toxicol, Vol. XXI
11. Cook JC, Johnson L, O'Connor JC, Biegel LB, Krams CH, Frame SR, Hurtt ME (1998) Effects of 17b-estradiol exposure on serum hormone concentrations and testicular parameters in male Crl:CD BR rats. Toxicol Sci 44:155-168.
12. Corpas I, Castillo M, Marquina D, Benito MJ (2002) Lead intoxication in gestational and lactation periods alters the development of male reproductive organs. Ecotoxicol Environ Saf 53:259-266.
13. Dawson EB, Harris WA, Rankin WE, Charpentier LA, McGanity WJ (1987) Effect of ascorbic acid on male fertility. Ann NY Acad Sci 498:312-323.
14. Dyson ALMB, Orgebin-Crist MC (1973) Effects of hypophysectomy, castration and androgen replacement upon the fertilizing ability of rat epididymal spermatozoa. Endocrinology 93:391-402.
15. Garcia-Fernandez AJ, Bayoumi AE, Perez-Pertejo Y, Motas M, Reguera RM, Ordonez C, Balana-Fouce R, Ordonez D (2002) Alterations of the glutathione-redox balance induced by metals in CHO-K1 cells. Comp Biochem Physiol C 132:365-373.
16. Goyal HO, Bartol FF, Wiley AA, Khalil MK, Williams CS, Vig MM (1998) Regulation of androgen and estrogen receptors in male excurrent ducts of the goat: an immunohistochemical study. Anat Rec 250:164-171.
17. Hoye AT, Davoren JE, Wipf P, Fink MP, Kagan VE (2008) Targeting mitochondria. Acc Chem Res 41:87-97.
18. Hsu PC, Liu MY, Hsu CC, Chen LY, Leon Guo Y (1997) Lead exposure causes generation of reactive oxygen species and functional impairment in rat sperm. Toxicology 26:133-143.
19. Hugo EA (1987) Catalase. In: Methods of Biochemical Analysis. Bergmeyer HU, Bergmeyer J, Grabt M (eds). VCH Publishers, New York, Vol. III, pp 277-282.
20. Jacobson KB, Turner JE (1980) The interaction of cadmium and certain other metal ions with proteins and nucleic acids. Toxicology 16:1-37.
21. Jamall IS, Sprowls JJ (1987) Effects of cadmium and dietary selenium on cytoplasmic and mitochondrial antioxidant defense systems in the heart of rats fed high dietary copper. Toxicol Appl Pharmacol 87:102-111.
22. Kaneto M, Kanamori S, Hishikawa A, Kishi K (1999) Epididymal sperm motion as a parameter of male reproductive toxicity: sperm motion, fertility, and histopathology in ethinylestradiol-treated rats. Reprod Toxicol 13:279-289.
23. Kaur P, Kaur G, Bansal MP (2006) Tertiary-butyl hydroperoxide induced oxidative stress and male reproductive activity in mice: role of transcription factor NF-kappaβ and testicular antioxidant enzymes. Reprod Toxicol 2(3):479-484.
24. Kempinas WG, Lamano-Carvalho TL, Petenusci SO, Favaretto AL, Lopes RA, Azoubel R (1988) Functional disturbance of rat sexual accessory glands in an early phase of lead intoxication. Gegenbaurs Morphol Jahrb 134:791-798.
25. Leffler HH, McDougald CH (1963) Estimation of cholesterol in serum by means of improved techniques. Am J Clin Pathol 39:311-314.
26. Liu MY, Lai HY, Yang BC, Tsai ML, Yang HY, Huang BM (2001) The inhibitory effects of lead on steroidogenesis in MA-10 mouse Leydig tumor cells. Life Sci, 12:849-859.
27. Maiorino M, Ursini F (2002) Oxidative stress, spermatogenesis and fertility. Biol Chem 383:591-597.
28. Manca D, Richard AC, Trottier B, Chevalier G (1991) Studies on lipid peroxidation in rat tissues following administration of low and moderate doses of cadmium chloride. Toxicology 67:303-323.
29. Marklund S, Marlund G (1974) Involvement of the superoxide anion radical in the oxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469-474.
30. Motoshima M, Settlage DS (1978) Determination of fructose and glucose in semen, evaluation and comparison of colorimetric and enzymatic methods. Nippon Funin Gakkai Zasshi 23:454-464.
31. Nampoothiri LP, Agarwal A, Gupta S (2007) Effect of co-exposure to lead and cadmium on antioxidant status in rat ovarian granulose cells. Arch Toxicol 81:145-150.
32. Ochi T, Takahashi K, Ohsawa M (1987) In direct evidence for the induction of a pro-oxidant state by cadmium chloride in cultured mammalian cells and a possible mechanism for the induction. Mutat Res 180:257-266.
33. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 19:351-358.
34. Ong CN, Shen HM, Chia SE (2002) Biomarkers for male reproductive health hazards: are they available? Toxicol Lett 134:17-30.
35. Orgebin-Crist MC (1996) Androgens and epididymal function. In: Pharmacology, Biology, and Clinical Application of Androgens. Bhasin D, Gabelnick HL, Spieler JM, Swerdloff RS, Wang C (eds). Wiley-Liss, New York, pp 27-38.
36. Paglia DE, Valentine WN (1987) Studies on the quantitative and qualitative characterization of glutathion proxidase. J Lab Med 70:158-165.
37. Pant N, Banerjee AK, Pandey S, Mathur N, Saxena DK, Srivastava SP (2003) Correlation of lead and cadmium in human seminal plasma with seminal vesicle and prostatic markers. Hum Exp Toxicol 22:125-128.
38. Pillai A, Gupta S (2005) Effect of gestational and lactational exposure to lead and/or cadmium on reproductive performance and hepatic oestradiol metabolising enzymes. Toxicol Lett 15:179-186.
39. Pillai A, Priya L, Gupta S (2003) Effect of combined exposure to lead and cadmium on hypothalamus-pituitary axis function in proestrous rats. Food Chem Toxicol, 41:379-384.
40. Pillai A, Patel R, Pandya C, Gupta S (2009) Sex-specific effects of gestational and lactational coexposure to lead and cadmium on hepatic phase I and phase II xenobiotic/steroid-metabolizing enzymes and antioxidant status. J Biochem Mol Toxicol 236:419-431.
41. Roe JΗ, Kuether CA (1942) A color reaction for dehydroascorbic acid useful in the determination of vitamin C. Science 95(2455):77.
42. Saleh RA, Agarwal A, Nelson DR, Nada EA, El-Tonsy MH, Alvarez JG, Thomas AJ, Sharma RK (2002) Increased sperm nuclear DNA damage in normozoospermic infertile men: a prospective study. Fertil Steril 78:313-318.
43. Sapper H, Kang S, Paul H, Lohmann W (1982) The reversibility of vitamin C redox system: electrochemical reasons and biochemical aspects. Z Naturforsch, 37:942-946.
44. Seligman J, Kosower NS, Shalgi R (1997) Effects of castration on thiol status in rat spermatozoa and epididymal fluid. Mol Reprod Dev 47:295-301.
45. Sharpe RM (1994) Could environmental oestrogenic chemicals be responsible for some disorders of human male reproductive development? Curr Opin Urol 4:295-301.
46. Shivanandappa T, Venkatesh S (1997) A calorimetric assay method for 3-β-hydroxy Δ5 steroid dehydrogenase. Anal Biochem 254:57-61.
47. Sies H (1991) Oxidative stress: introduction. In: Oxidants and Antioxidants. Sies H (ed). Academic Press, San Diego, CA, pp 15-22.
48. Snyder RD (1988) Role of active oxygen species in metal-induced DNA strand breakage in human diploid fibroblasts. Mutat Res 193:237-246.
49. Stoica A, Katzenellenbogen BS, Martin MB (2000) Activation of estrogen receptor-α by the heavy metal cadmium. Mol Endocrinol 14:545-553.
50. Sujarit S, Pholpramool C (1985) Enhancement of sperm transport through the rat epididymis after castration. J Reprod Fertil 5:497-502.
51. Syntin P, Dacheux JL, Dacheux F (1999) Post natal development and regulation of proteins secreted in the boar epididymis. Biol Reprod 61:1622-1635.
52. Taupeau C, Poupon J, Treton D, Brosse A, Richard Y, Machelon V (2003) Lead reduces messenger RNA and protein levels of cytochrome p450 aromatase and estrogen receptor beta in human ovarian granulosa cells. Biol Reprod 68:1982-1988.
53. Tohda A, Matsumiya K, Tadokoro Y (2001) Testosterone spermatogenesis in juvenile spermatogonial depletion (jsd) mice. Biol Reprod 65:532-537.
54. Whelton BD, Toomey JM, Bhattacharyya MH (1993) Cadmium-109 metabolism in mice. Diet versus maternal stores as a source of cadmium transfer to mouse fetuses and pups during gestation and lactation. J Toxicol Environ Health 40:531-546.
55. Wiebe JP (1969) Steroid dehydrogenases and steroids in gonads of the Sea perch cymatogaster aggregate Gibbons. Gen Comp Endocrinol 12:256-266.
56. Yang JM, Arnush M, Chen QY, Wu XD, Pang B, Jiang XZ (2003) Cadmium-induced damage to primary cultures of rat Leydig cells. Reprod Toxicol 17:553-560.
57. Yang HS, Han DK, Kim JR, Sim JC (2006) Effects of alpha-tocopherol on cadmium-induced toxicity in rat testis and spermatogenesis. J Korean Med Sci 21:445-451.
58. Zhang H, Bai X, Zheng X (1999) Distribution of lead in fetal rat tissue at different days of pregnancy. Wei Sheng Yan Jiu 28:88-90.
59. Zumkley H (1988) Clinical aspects of selenium metabolism. Biol Trace Elem Res 15:139-146.