[ 11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Frankle, W Gordon ^a   Cho, Raymond Y ^a   Mason, N Scott ^a   Chen, Chi Min ^a   Himes, Michael ^a   Walker, Christopher ^a   Lewis, David A ^a   Mathis, Chester A ^a   Narendran, Rajesh ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; FLUMAZENIL; TIAGABINE; TRACER; 4 AMINOBUTYRIC ACID CARRIER; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; CARBON; LIGAND; NIPECOTIC ACID DERIVATIVE; SLC6A1 PROTEIN, HUMAN;

4 AMINOBUTYRIC ACID METABOLISM; ADULT; AMYGDALOID NUCLEUS; ARTICLE; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG BINDING; ENTORHINAL CORTEX; FEMALE; FRONTAL CORTEX; GABAERGIC SYSTEM; HIPPOCAMPUS; HUMAN; IN VIVO STUDY; MALE; PARAHIPPOCAMPAL PLACE AREA; POSITRON EMISSION TOMOGRAPHY; ELECTROENCEPHALOGRAPHY; ELECTROPHYSIOLOGY; METABOLISM; METHODOLOGY; REGRESSION ANALYSIS; STATISTICAL MODEL;

ADULT; CARBON ISOTOPES; COGNITION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; ELECTROPHYSIOLOGY; FEMALE; FLUMAZENIL; GABA MODULATORS; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; HUMANS; LIGANDS; MALE; MODELS, STATISTICAL; NIPECOTIC ACIDS; POSITRON-EMISSION TOMOGRAPHY; REGRESSION ANALYSIS;

EID: 84863249721     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032443     Document Type: Article

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