Enhanced biological effects of Phe140Asn, a novel human granulocyte colony-stimulating factor mutant, on HL60 cells

BMB Reports

Volumn 44, Issue 10, 2011, Pages 686-691

  Chung, Hee Kyoung ^a,b   Kim, Sung Woo ^a   Byun, Sung June ^a   Ko, Eun Mi ^a   Chung, Hak Jae ^a   Woo, Jae Seok ^a   Yoo, Jae Gyu ^a   Lee, Hwi Cheul ^a   Yang, Byoung Chul ^a   Kwon, Moosik ^b   Park, Soo Bong ^a   Park, Jin Ki ^a   Kim, Kyung Woon ^a  

^a National Institute of Animal Science   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

Biological activity; G CSF; N linked glycosylation; Neutropenia

Indexed keywords

BIRC5 PROTEIN, HUMAN; CHEMOTACTIC FACTOR; GRANULOCYTE COLONY STIMULATING FACTOR; INHIBITOR OF APOPTOSIS PROTEIN; JAK2 PROTEIN, HUMAN; JANUS KINASE 2; STAT3 PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN HL 60; CHEMISTRY; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MUTATION; NEUTROPENIA; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CELL DIFFERENTIATION; CHEMOTACTIC FACTORS; GRANULOCYTE COLONY-STIMULATING FACTOR; HL-60 CELLS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; JANUS KINASE 2; MUTATION; NEUTROPENIA; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84863246711     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2011.44.10.686     Document Type: Article

References (25)

1. Bishop, B., Koay, D. C., Sartorelli, A. C. and Regan, L. (2001) Reengineering granulocyte colony-stimulating factor for enhanced stability. J. Biol. Chem. 276, 33465-33470.
2. Ribeiro, D., Veldwijk, M. R., Benner, A., Laufs, S., Wenz, F., Ho, A. D. and Fruehauf, S. (2007) Differences in functional activity and antigen expression of granulocytes primed in vivo with filgrastim, lenograstim, or pegfilgrastim. Transfusion 47, 969-980.
3. Burgess, A. W. and Metcalf, D. (1980) The nature and action of granulocyte-macrophage colony stimulating factors. Blood 56, 947-958.
4. Hill, C. P., Osslund, T. D. and Eisenberg, D. (1993) The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors. Proc. Natl. Acad. Sci. U.S.A. 90, 5167-5171.
5. Tamada, T., Honjo, E., Maeda, Y., Okamoto, T., Ishibashi, M., Tokunaga, M. and Kuroki, R. (2006) Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex. Proc. Natl. Acad. Sci. U.S.A. 103, 3135-3140.
6. Jiang, K., Hein, N., Eckert, K., Luscher-Firzlaff, J. and Luscher, B. (2008) Regulation of the MAD1 promoter by G-CSF. Nucleic Acids Res. 36, 1517-1531.
7. Gu, L., Chiang, K. Y., Zhu, N., Findley, H. W. and Zhou, M. (2007) Contribution of STAT3 to the activation of survivin by GM-CSF in CD34+ cell lines. Exp. Hematol. 35, 957-966.
8. Chakraborty, A., White, S. M., Schaefer, T. S., Ball, E. D., Dyer, K. F. and Tweardy, D. J. (1996) Granulocyte colony-stimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells. Blood 88, 2442-2449.
9. Yin, S., Wang, R., Zhou, F., Zhang, H. and Jing, Y. (2011) Bcl-XL is a dominant antiapoptotic protein which inhibits homoharringtonine-induced apoptosis in leukemia cells. Mol. Pharmacol. 79, 1072-1083
10. Gervais, V., Zerial, A. and Oschkinat, H. (1997) NMR investigations of the role of the sugar moiety in glycosylated recombinant human granulocyte-colony-stimulating factor. Eur. J. Biochem. 247, 386-395.
11. Cumming, D. A. (1991) Glycosylation of recombinant protein therapeutics: control and functional implications. Glycobiology 1, 115-130.
12. Lu, H. S., Boone, T. C., Souza, L. M. and Lai, P. H. (1989) Disulfide and secondary structures of recombinant human granulocyte colony stimulating factor. Arch. Biochem. Biophys. 268, 81-92.
13. Ishikawa, M., Iijima, H., Satake-Ishikawa, R., Tsumura, H., Iwamatsu, A., Kadoya, T., Shimada, Y., Fukamachi, H., Kobayashi, K., Matsuki, S. and Asano, K. (1992) The substitution of cysteine 17 of recombinant human G-CSF with alanine greatly enhanced its stability. Cell Struct. Funct. 17, 61-65.
14. Shimozaki, K., Nakajima, K., Hirano, T. and Nagata, S. (1997) Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells. J. Biol. Chem. 272, 25184-25189.
15. Zaker, F., Oody, A. and Arjmand, A. (2007) A study on the antitumoral and differentiation effects of peganum harmala derivatives in combination with ATRA on leukaemic cells. Arch. Pharm. Res. 30, 844-849.
16. Detmers, P. A., Thieblemont, N., Vasselon, T., Pironkova, R., Miller, D. S. and Wright, S. D. (1996) Potential role of membrane internalization and vesicle fusion in adhesion of neutrophils in response to lipopolysaccharide and TNF. J. Immunol. 157, 5589-5596.
17. Avalos, B. R. (1996) Molecular analysis of the granulocyte colony-stimulating factor receptor. Blood 88, 761-777.
18. Gascan, H., Moreau, J. F., Jacques, Y. and Soulillou, J. P. (1989) Response of murine IL3-sensitive cell lines to cytokines of human and murine origin. Lymphokine Res. 8, 79-84.
19. Shimoda, K., Iwasaki, H., Okamura, S., Ohno, Y., Kubota, A., Arima, F., Otsuka, T. and Niho, Y. (1994) G-CSF induces tyrosine phosphorylation of the JAK2 protein in the human myeloid G-CSF responsive and proliferative cells, but not in mature neutrophils. Biochem. Biophys. Res. Commun. 203, 922-928.
20. Li, J. and Sartorelli, A. C. (1994) Evidence for the glycosylation of the granulocyte colony-stimulating factor receptor. Biochem. Biophys. Res. Commun. 205, 238-244.
21. Dangoor, D., Biondi, B., Gobbo, M., Vachutinski, Y., Fridkin, M., Gozes, I. and Rocchi, R. (2008) Novel glycosylated VIP analogs: synthesis, biological activity, and metabolic stability. J. Pept. Sci. 14, 321-328.
22. Orlic, D., Kajstura, J., Chimenti, S., Limana, F., Jakoniuk, I., Quaini, F., Nadal-Ginard, B., Bodine, D. M., Leri, A. and Anversa, P. (2001) Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl. Acad. Sci. U.S.A. 98, 10344-10349.
23. Gomez-Cambronero, J., Horn, J., Paul, C. C. and Baumann, M. A. (2003) Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. J. Immunol. 171, 6846-6855.
24. Kojima, H., Otani, A., Oishi, A., Makiyama, Y., Nakagawa, S. and Yoshimura, N. (2011) Granulocyte colony-stimulating factor attenuates oxidative stress-induced apoptosis in vascular endothelial cells and exhibits functional and morphologic protective effect in oxygen-induced retinopathy. Blood 117, 1091-1100.
25. Pene, F., Claessens, Y. E., Muller, O., Viguie, F., Mayeux, P., Dreyfus, F., Lacombe, C. and Bouscary, D. (2002) Role of the phosphatidylinositol 3-kinase/Akt and mTOR/ P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma. Oncogene 21, 6587-6597.