A novel anticancer agent, SKLB70359, inhibits human hepatic carcinoma cells proliferation via G0/G1 cell cycle arrest and apoptosis induction

Cellular Physiology and Biochemistry

Volumn 29, Issue 1-2, 2012, Pages 281-290

  Dai, Xiao Yun ^a   Zeng, Xiu Xiu ^a   Peng, Feng ^a   Han, Yuan Yuan ^a   Lin, Hong Jun ^a   Xu, You Zhi ^a   Zhou, Tian ^a   Xie, Gang ^a   Deng, Yi ^a   Mao, Yong Qiu ^a   Yu, Luo Ting ^a   Yang, Li ^a   Zhao, Ying Lan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Apoptosis; G0 G1 cell cycle arrest; SKLB70359

Indexed keywords

3 AMINO 6 (3,4 DICHLOROPHENYL)THIENO[2,3 B]PYRIDINE 2 CARBOXAMIDE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P44; PROTEIN P53; SKLB 70359; THIENO[2,3 B]PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; HUMAN; HUMAN TISSUE; IC 50; LIVER CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

EID: 84863239808     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000337609     Document Type: Article

References (29)

1. Altekruse SF, McGlynn KA, Reichman ME: Hepatocellular carcinoma incidence, mortality, and survival trends in the united states from 1975 to 2005. J Clin Oncol 2009;27:1485.
2. Thomas MB, Zhou AX: Hepatocellular carcinoma: The need for progress. J Clin Oncol 2005;23:2892-2899.
3. Elserag H, Marrero J, Rudolph L, Reddy K: Diagnosis and treatment of hepatocellular carcinoma. Gastroenterology 2008;134:1752-1763.
4. Llovet JM, Bruix J: Molecular targeted therapies in hepatocellular carcinoma. Hepatology 2008;48:1312-1327.
5. Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378-390.
6. Massagué J: G1 cell-cycle control and cancer. Nature 2004;432:298-306.
7. Lee B, Kim CH, Moon SK: Honokiol causes the p21WAF1-mediated G (1)- phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells. FEBS lett 2006;580:5177-5184.
8. Malumbres M, Pevarello P, Barbacid M, Bischoff JR: Cdk inhibitors in cancer therapy: What is next? Trends Pharmacol Sci 2008;29:16-21.
9. Musgrove EA, Caldon CE, Barraclough J, Stone A, Sutherland RL: Cyclin D as a therapeutic target in cancer. Nat Rev Cancer 2011;11:558-572
10. Tong WG, Chen R, Plunkett W, Siegel D, Sinha R, Harvey RD, Badros AZ, Popplewell L, Coutre S, Fox JA, Mahadocon K, Chen TL, Kegley P, Hoch U, Wierda WG: Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma. J Clin Oncol 2010;28:3015-3022.
11. Zeng XX, Zheng RL, Zhou T, He HY, Liu JY, Zheng Y, Tong AP, Xiang ML, Song XR, Yang SY, Wei YQ, Zhao YL, Yang L: Novel thienopyridine derivatives as specific anti-hepatocellular carcinoma (HCC) agents: Synthesis, preliminary structure-Activity relationships, and in vitro biological evaluation. Bioorg Med Chem Lett 2010;20:6282-6285.
12. Jiang PD, Zhao YL, Shi W, Deng XQ, Xie G, Mao YQ, Li ZG, Zheng YZ, Yang SY, Wei YQ: Cell growth inhibition, G2/ M cell cycle arrest, and apoptosis induced by chloroquine in human breast cancer cell line Bcap-37. Cell Physiol Biochem 2008;22:431-440.
13. Zheng Y, Zhao YL, Deng X, Yang S, Mao Y, Li Z, Jiang P, Zhao X, Wei Y: Chloroquine inhibits colon cancer cell growthin vitroand tumor growthin vivovia induction of apoptosis. Cancer Invest 2009;27:286-292.
14. Taya Y: Rb kinases and rb-binding proteins: New points of view. Trends Biochem Sci 1997;22:14-17.
15. Moldovan GL, Pfander B, Jentsch S: PCNA, the maestro of the replication fork. Cell 2007;129:665-679.
16. Obaya AJ, Sedivy JM: Regulation of cyclin-cdk activity in mammalian cells. Cell Mol Life Sci 2002;59:126-142.
17. Malumbres M, Barbacid M: Cell cycle, cdks and cancer: A changing paradigm. Nat Rev Cancer 2009;9:153-166.
18. Harbour JW, Dean DC: Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol 2000;2:E65-E67.
19. Huang LC, Clarkin KC, Wahl GM: Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest. Proc Natl Acad Sci USA 1996;93:4827.
20. Waldman T, Kinzler KW, Vogelstein B: P21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res 1995;55:5187.
21. Taldone T, Gozman A, Maharaj R, Chiosis G: Targeting hsp90: Small-molecule inhibitors and their clinical development. Curr Opin Pharmacol 2008;8:370-374.
22. Srethapakdi M, Liu F, Tavorath R, Rosen N: Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest. Cancer Res 2000;60:3940-3946.
23. Peng B, Xu L, Cao F, Wei T, Yang C, Uzan G, Zhang D: Research Hsp90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way. Mol Cancer 2010;9:79.
24. Motomura W, Tanno S, Takahashi N, Nagamine M, Fukuda M, Kohgo Y, Okumura T: Involvement of MEK-ERK signaling pathway in the inhibition of cell growth by troglitazone in human pancreatic cancer cells. Biochem Biophys Res Commun 2005;332:89-94.
25. Hubina E, Nanzer AM, Hanson MR, Ciccarelli E, Losa M, Gaia D, Papotti M, Terreni MR, Khalaf S, Jordan S, Czirják S, Hanzély Z, Nagy GM, Góth MI, Grossman AB, Korbonits M: Somatostatin analogues stimulate p27 expression and inhibit the map kinase pathway in pituitary tumours. Eur J Endocrinol 2006;155:371-379.
26. Tu Y, Wu W, Wu T, Cao Z, Wilkins R, Toh BH, Cooper ME, Chai Z: Antiproliferative autoantigen CAD1 transcriptionally up-regulates p21Waf1/ Cip1 by activating p53 and MEK/ERK1/ 2 MAPK pathways. J Biol Chem 2007;282:11722-11731.
27. Ye M, Liu J, Lu Z, Zhao Y, Liu S, Li L, Tan M, Weng X, Li W, Cao Y: Grifolin, a potential antitumor natural product from the mushroom albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro. FEBS Lett 2005;579:3437-3443.
28. Krishnan A, Hariharan R, Nair SA, Pillai MR: Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Bioc. Pharmacol 2008;75:1924-1934.
29. Fan TJ, Han LH, Cong RS and Liang J: Caspase family proteases and apoptosis. Acta Biochim Biophys Sin 2005;11:719-727.