Evaluation of antioxidant, anti-inflammatory and analgesic potential of the Luffa acutangula Roxb. Var. amara

Research Journal of Phytochemistry

Volumn 5, Issue 4, 2011, Pages 201-208

  Gill, Naresh Singh ^a   Arora, Rashmi ^a   Kumar, Shiv Ranjan ^a  

^a Rayat School of Pharmacy   (India)

Author keywords

Analgesic; Anti inflammatory; Antioxidant; Hydrogen peroxide; Luffa acutangula Roxb. Var. amara

Indexed keywords

LUFFA ACUTANGULA; RATTUS;

EID: 84863230123     PISSN: 18193471     EISSN: None     Source Type: Journal    
DOI: 10.3923/rjphyto.2011.201.208     Document Type: Article

References (41)

1. Agrahari, A.K., K. Khaliquzzama and S.K. Panda, 2010. Evaluation of analgesic activity of methanolic extract of Trapanatans var. bispinos Roxb. roots. Int. J. Currert. Ph. Res., 1: 8-11.
2. Al-Mustafa, A.H. and O.Y. Al-Thunibat, 2008. Antioxidant activity of some Jordanian medicinal plants used traditionally for treatment of diabetes. Pak. J. Biol. Sci., 11: 351-358.
3. Alam, M.B., M.S. Hossain, N.S. Chowdhury, M. Asadujjaman and R. Zahan et al., 2011. Antioxidant, anti-inflammatory and anti-pyretic activities of Trichosanthes dioicaJioxb. fruits. J. Pharmacol. Toxicol., 6: 440-453.
4. Antonio, M.A. and A.R.M.S. Brito, 1998. Oral anti-inflammatory and anti-ulcerogenic activities of a hydro alcoholic extract and partitioned fractions of Turnera ulmifolia (Turneraceae). J. Ethnopharmacol., 61: 215-228.
5. Archana, S. Jatawa, R. Paul and A. Tiwari, 2011. Indian medicinal plants: A rich source of natural immuno-modulator. Int. J. Pharmacol., 7: 198-205.
6. Ashutosh, M., P.D. Kumar, M.M. Ranjan, M. Arnabaditya and M. Ashutosh, 2009. Analgesic and anti-inflammatory effect of Ichnocarpus frutescens plant parts. Int. J. Ph. Sci., 1: 280-283.
7. Chiang, Y.M., D.Y. Chuang, S.Y. Wang, Y.H. Kuo, P.W. Tsai and L.F. Shyur, 2004. Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa. J. Ethnopharmacol., 95: 409-419.
8. Czochra, M.P. and A. Widensk, 2002. Spectrometric determination of hydrogen peroxide scavenging activity. J. Anal. Chimica Acta, 452: 177-184.
9. Ehsabetsky, E., T.A. Amador, R.R. Albuquerque, D.S. Nunes and A.C.T. Carvalho, 1995. Analgesic activity of Psychotria colorata (Willd. ex R. and S.) Muell. Arg. alkaloids. J. Ethnopharmacol., 48: 77-83.
10. Galati, E.M., M.T. Monforte, S. Kirjavainen, A.M. Forestieri, A. Trovato and M.M. Tripodo, 1994. Biological effects of hesperidin, a citrus flavonoid. (Note I): Antiinflammatory and analgesic activity. Farmaco, 40: 709-712.
11. Geetha, M., A.K. Saluja, M.B. Shankar and R.S. Mehta, 2004. Analgesic and anti-inflammatory activity of Couroupitaguianensis Aubl. J. Nat. Remedies, 4: 52-55.
12. Gill, N.S., S. Sood, A. Muthuraman, M. Garg, R. Kumar, M. Bali and P.D. Sharma, 2010. Antioxidant, anti-inflammatory and analgesic potential of Cucumis sativus seed extract. Lat. Am. J. Pharma., 29: 927-932.
13. Gill, N.S., J. Bajwa, K. Dhiman, P. Sharma and S. Sood et al., 2011. Evaluation of therapeutic potential of traditionally consumed Cucumis melo seeds. Asian J. Plant Sci., 10: 86-91.
14. Hanasaki, Y., S. Ogawa and S. Fukui, 1994. The correlation between active oxygens scavenging and antioxidative effects of flavonoids. Free Radical Biol. Med., 16: 845-850.
15. Hatano, T., H. Kagawa, T. Yasuhara and T. Okuda, 1988. Two new flavonoids and other constituents in licorice: Their relative astringency and radical scavenging effects. Cheni. Pharm. Bull., 36: 2090-2097.
16. Headley, P.M. and C.T. Shaughnessy, 1985. Evidence for opiate and dopamine interaction in striatum. Br. J. Pharmacol., 86: 700-700.
17. Joseph, B. and S.J. Raj, 2011. A comparative study on various properties of five medicinally important plant. Int. J. Pharmacol., 7: 206-211.
18. Junaid, K.M., Ajazuddin, V. Amber, S. Manju and S. Deependra, 2011. Acute and chronic effect of Hibiscus rosa sinesis flower extract on anxiety induced exploratory and locomotor activity in mice. J. Plant. Sci., (In Press).
19. Kapoor, S. and S. Saraf, 2011. Tropical herbal therapies an alternative and complementary choice to combact acne. Res. J. Med. Plant, (In press).
20. Karim, A., M. Nouman, S. Munir and S. Sattar, 2011. Pharmacology and phytochemistry of Pakistani herbs and herbal drugs used for treatment of diabetes. Int. J. Pharmacol., 7: 419-439.
21. Khasawneh, M.A., H.M. Elwy, N.M. Fawzi, A.A. Hamza, A.R. Chevidenkandy and A.H. Hassan, 2011. Antioxidant activity, lipoxygenase inhibitory effect and polyphenolic compounds from Calotropis procera (Ait.) R. Br. Res. J. Phytochem., 5: 80-88.
22. Kim, H.K., S.K. Park, J.L. Zhou, G. Taghalatela, K. Chung, R.E. Coggeshall and J.M. Chung, 2004. Reactive oxygen species (ROS) play an important role in the rat model of neuropathic pain. Pain, 111: 116-124.
23. Kokate, C.K., A.P. Purohit and S.B. Gokhale, 2000. Textbook of Pharmacognosy. Nirali Prakasan, Pune, India.
24. Mohan, G.K. and J.S. Sanjay, 2010. Pharmacognostic and phytochemical investigation of huffa acutangula var. amara fruits. Int. J. PharmTech. Res., 2: 1609-1614.
25. Najiah, M., M. Nadirah, Z. Arief, S. Zahrol and L.W. Tee et al., 2011. Antibacterial activity of malaysian edible herbs extracts on fish pathogenic bacteria. Res. J. Med. Plant, 5: 772-778.
26. Nenaah, E.G. and M.E. Ahmed, 2011. Antimicrobial activity of extracts and latex of Calotropis procera (Ait.) and synergistic effect with reference antimicrobials. Res. J. Med. Plant, 5: 706-716.
27. Nithya, V. and A. Baskar, 2011. A preclinical study on wound healing activity of Lawsonia ulba Linn. Res. J. Phytochem., 5: 123-129.
28. Oladosu, LA., A.L. Ogundajo, O.O. Alyelaagbe and N. Emenyonu, 2011. Phytochemical and antituberculosis activity of Coffea briuipes, hiern extracts. Res. J. Phytochem., 5: 130-135.
29. Pal, S., T. Sen and A.K. Chaudhuri, 1999. Neuropsychopharmacological profile of the methanolic fraction of Bryophyllum pinnatum leaf extract. J. Pharm. Pharmacol., 51: 313-318.
30. Premanath, R., J. Sudisha, N.L. Devi and S.M. Aradhya, 2011. Antibacterial and anti-oxidant activities of fenugreek {Trigonella foenum graecum L.) leaves. Res. J. Med. Plant, 5: 695-705.
31. Ravi, V., T.S.M. Saleem, S.S. Patel, Raamamurthy and .J. Gauthaman, 2009. Anti-inflammatory effect of methanolic extract of Solarium nigrum Linn Berries. Int. J. Applied Res. Nat. Prod., 2: 33-36.
32. Rokyta, R., V. Holecek, I. Pekarkova, J. Krejcova, J. Racek, L. Trefil and A. Yamamotova, 2003. Free radicals after painful, stimulation are influenced by antioxidants and analgesics. Neuro Endocrmol. Lett., 24: 304-309.
33. Rolland, A., J. Fleurentam, M.C. Lanhers, C. Younos, R. Misslm, F. Mortier and J.M. Pelt, 1991. Behavioural effects of American traditional plant Eschscholzia calif arnica: Sedative and anxiolytic properties. Planta Med., 57: 212-216.
34. Shah, B.N. and A.K. Seth, 2010. Screening of Lagenaria siceraria fruits for their analgesic activity. Rom. J. Biol. Plant. Biol., 55: 23-26.
35. Susithra, E., K.M. Rao, K.V. Ramsesu and A. Saraswathy, 2010. Evaluation of anti- inflammatory activity of seeds of Luffa cylindrica. J. Pham. Res., 3: 1496-1498.
36. Trease, G.E. and W.C. Evans, 1983. A Textbook of Pharmacognosy. 12th Edn., Baillere Tmdall, London, pp: 387-476.
37. Vinegar, R., J.F. Truax and J.L. Selph, 1976. Quantitative studies of the pathway to acute carrageenan inflammation. Fed. Proc, 35: 2447-2456.
38. Winrow, V.R., P.G. Winyard, C.J. Morris and D.R. Blake, 1993. Free radicals in inflammation: Second messengers and mediators of tissue destruction. Br. Med. Bull., 49: 506-522.
39. Winter, G.A., E.A. Risley and G.W. Nuss, 1962. Garrageenan induced edema in hind paw of the rat as an assay for anti-inflammatory drug. Proc. Soc. Exp. Biol. Med., Ill: 544-547.
40. Yoganandam, G.P., K. Ilango, K. Sunil and A. Elumalai, 2010. In vitro antioxidant activity of Luffa cylindrica seed oil. J. Global. Pharma. Technol., 2: 93-97.
41. Zayachkivska, O.S., S.G. Konturek, D. Drozdowicz, P.G. Konturek, T. Brzozowski and M.R. Ghegotsky, 2005. Gastroprotective effects of fLavonoids in plant extracts. J. Physiol. Pharm., 56: 219-231.