Nucleoplasmic calcium buffering sensitizes human squamous cell carcinoma to anticancer therapy

Journal of Cancer Science and Therapy

Volumn 4, Issue 5, 2012, Pages 131-139

  Andrade, Lídia M ^a   Geraldo, Jony M ^b   Gonçalves, Osvaldo X ^b   Leite, Miguel T T ^b   Catarina, Anderson M ^b   Guimarães, Melissa M ^c   Leme, Adriana F P ^d   Yokoo, Sami ^d   Machado, Carlos R ^e   Rajão, Matheus A ^e   Carvalho, Sandhra M ^e   Gomes, Dawidson A ^e   Aguiar, Carla J ^e   Souza Fagundes, Elaine M ^e   Zani, Carlos L ^a   Resende, Rodrigo R ^e   Martins Filho, Olindo A ^a   Leite, M Fátima ^e,f  

^a Laboratory of Biomarkers and Monitoring   (Brazil)

^b São Francisco Radiotherapy Institute   (Brazil)

^c UNIVERSIDADE FEDERAL DOS VALES DO JEQUITINHONHA E MUCURI   (Brazil)

^d BRAZILIAN CENTER FOR RESEARCH IN ENERGY AND MATERIALS CNPEM   (Brazil)

^e FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

A431 cells; Head and neck tumor; Human squamous cell carcinoma; Nuclear calcium buffering; X rays irradiation

Indexed keywords

BUFFER; CALCIUM ION; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOCHONDRIAL DNA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ARTICLE; CANCER RADIOTHERAPY; CANCER THERAPY; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; IRRADIATION; NUCLEOLUS; PROTEIN EXPRESSION; RADIATION DOSE; RADIOSENSITIVITY; RADIOTHERAPY; SIMULATION; SQUAMOUS CELL CARCINOMA; X IRRADIATION;

EID: 84863227112     PISSN: None     EISSN: 19485956     Source Type: Journal    
DOI: 10.4172/1948-5956.1000127     Document Type: Article

References (61)

1. Ragin CC, Modugno F, Gollin SM (2007) The epidemiology and risk factors of head and neck cancer: a focus on human papillomavirus. J Dent Res 86:104-114.
2. Diaz EM, Kies MS, Sturgis EM, Clayman L, Laramore GE, et al. (2006) Head and Neck: Cancer Medicine (7th edn), BC Decker, Hamilton, Ontário.
3. Affolter A, Fruth K, Brochhausen C, Schmidtmann I, Mann WJ, et al. (2011) Activation of mitogen-activated protein kinase extracellular signal-related kinase in head and neck squamous cell carcinomas after irradiation as part of a rescue mechanism. Head Neck 33: 1448-1457.
4. Schmidt-Ullrich RK, Contessa JN, Lammering G, Amorino G, Lin PS (2003) ERBB receptor tyrosine kinases and cellular radiation responses.Oncogene 22: 5855-5865.
5. Jonathan RA, Wijffels KI, Peeters W, de Wilde PC, Marres HA, et al. (2006) The prognostic value of endogenous hypoxia-related markers for head and neck squamous cell carcinomas treated with ARCON. Radiother Oncol 79: 288-297.
6. Paganetti H (2005) Changes in tumor cell response due to prolonged dose delivery times in fractionated radiation therapy. Int J Radiat Oncol Biol Phys 63: 892-900.
7. Ang KK, Berkey BA, Tu X, Zhang HZ, Katz R, et al. (2002) Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 62: 7350-7356.
8. Liang K, Ang KK, Milas L, Hunter N, Fan Z (2003) The epidermal growth factor receptor mediates radioresistance. Int J Radiat Oncol Biol Phys 57: 246-254.
9. Todd DG, Mikkelsen RB (1994) Ionizing radiation induces a transient increase in cytosolic free [Ca2+] in human epithelial tumor cells. Cancer Res 54: 5224-5230.
10. Berridge MJ (2009) Inositol trisphosphate and calcium signalling mechanisms. Biochim Biophys Acta 1793: 933-940.
11. Rodrigues MA, Gomes DA, Leite MF, Grant W, Zhang L, et al. (2007) Nucleoplasmic calcium is required for cell proliferation. J Biol Chem 282: 17061-17068.
12. Andrade V, Guerra M, Jardim C, Melo F, Silva W, et al. (2011) Nucleoplasmic calcium regulates cell proliferation through legumain. J Hepatol 55: 626-635.
13. Foo CC, Lee JS, Guilanno V, Yan X, Tan SH, et al. (2007) Squamous cell carcinoma and Bowen's disease of the skin in Singapore. Ann Acad Med Singapore 36: 189-193.
14. Bonner JA, Trummell HQ, Willey CD, Plants BA, Raisch KP (2009) Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma. Radiother Oncol 92: 339-344.
15. Sah NK, Munshi A, Nishikawa T, Mukhopadhyay T, Roth JA, et al. (2003) Adenovirus-mediated wild-type p53 radiosensitizes human tumor cells by suppressing DNA repair capacity. Mol Cancer Ther 2: 1223-1231.
16. Schmidt-Ullrich RK, Mikkelsen RB, Dent P, Todd DG, Valerie K, et al. (1997) Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 15: 1191-1197.
17. Xiao H, Zhang Q, Shen J, Bindokas V, Xing HR (2010) Pharmacologic inactivation of kinase suppressor of Ras1 sensitizes epidermal growth factor receptor and oncogenic Ras-dependent tumors to ionizing radiation treatment. Mol Cancer Ther 9: 2724-2736.
18. Gomes DA, Rodrigues MA, Leite MF, Gomez MV, Varnai P, et al. (2008) c-Met must translocate to the nucleus to initiate calcium signals. J Biol Chem 283: 4344-4351.
19. Franken NA, Rodermond HM, Stap J, Haveman J, van Bree C (2006) Clonogenic assay of cells in vitro. Nat Protoc 1: 2315-2319.
20. Riccardi C, Nicoletti I (2006) Analysis of apoptosis by propidium iodide staining and flow cytometry. Nat Protoc 1: 1458-1461.
21. Guerra MT, Fonseca EA, Melo FM, Andrade VA, Aguiar CJ, et al. (2011) Mitochondrial calcium regulates rat liver regeneration through the modulation of apoptosis. Hepatology 54: 296-306.
22. Hall EJ, Giaccia AJ (2006) Radiobiology for the Radiologist. (3rdedn), Lippincott Williams & Wilkins, Philadelphia.
23. Yan D, Lockman D, Brabbins D, Tyburski L, Martinez A (2000) An off-line strategy for constructing a patient-specific planning target volume in adaptive treatment process for prostate cancer. Int J Radiat Oncol Biol Phys 48: 289-302.
24. Kantzou I, Platoni K, Sandilos P, Gouliamos A, Kouvaris I, et al. (2011) Conventional versus virtual simulation for radiation treatment planning of prostate cancer: final results. J BUON 16: 309-315.
25. Khan FM (2010) The physics of radiation therapy. (4thedn), Lippincott Williams & Wilkins, Philadelphia.
26. Yorke E, Gelblum D, Ford E (2011) Patient safety in external beam radiation therapy. AJR Am J Roentgenol 196: 768-772.
27. Purdy JA (2008) Principles of radiologic physics, dosimetry and treatment planning: Principles and Practice of Radiation Oncology. (5thedn), Lippincott Williams & Wilkins, Philadelphia.
28. Cerella C, Diederich M, Ghibelli L (2010) The dual role of calcium as messenger and stressor in cell damage, death, and survival. Int J Cell Biol 2010: 546163.
29. Várnai P, Lin X, Lee SB, Tuymetova G, Bondeva T, et al. (2002) Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130. J Biol Chem 277: 27412-27422.
30. Rodrigues MA, Gomes DA, Andrade VA, Leite MF, Nathanson MH (2008) Insulin induces calcium signals in the nucleus of rat hepatocytes. Hepatology 48: 1621-1631.
31. Rosier JF, Michaux L, Ameye G, Cedervall B, Libouton JM, et al. (2003) The radioenhancement of two human head and neck squamous cell carcinomas by 2'-2' difluorodeoxycytidine (gemcitabine; dFdC) is mediated by an increase in radiation-induced residual chromosome aberrations but not residual DNA DSBs. Mutat Res 527: 15-26.
32. Milas L, Fan Z, Andratschke NH, Ang KK (2004) Epidermal growth factor receptor and tumor response to radiation: in vivo preclinical studies. Int J Radiat Oncol Biol Phys 58: 966-971.
33. Blobel CP (2005) ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol 6: 32-43.
34. Cai CQ, Peng Y, Buckley MT, Wei J, Chen F, et al. (2008) Epidermal growth factor receptor activation in prostate cancer by three novel missense mutations. Oncogene 27: 3201-3210.
35. Dirix P, Nuyts S (2010) Evidence-based organ-sparing radiotherapy in head and neck cancer. Lancet Oncol 11: 85-91.
36. Ramaekers BL, Joore MA, Grutters JP, van den Ende P, Jong J, et al. (2011) The impact of late treatment-toxicity on generic health-related quality of life in head and neck cancer patients after radiotherapy. Oral Oncol 47: 768-774.
37. Allbritton NL, Oancea E, Kuhn MA, Meyer T (1994) Source of nuclear calcium signals. Proc Natl Acad Sci USA 91: 12458-12462.
38. Brini M, Murgia M, Pasti L, Picard D, Pozzan T, et al. (1993) Nuclear Ca2+ concentration measured with specifically targeted recombinant aequorin. EMBO J 12: 4813-4819.
39. Hennager DJ, Welsh MJ, DeLisle S (1995) Changes in either cytosolic or nucleoplasmic inositol 1,4,5-trisphosphate levels can control nuclear Ca2+ concentration. J Biol Chem 270: 4959-4962.
40. Lipp P, Thomas D, Berridge MJ, Bootman MD (1997) Nuclear calcium signalling by individual cytoplasmic calcium puffs. EMBO J 16: 7166-7173.
41. Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH (1995) ATP- dependent accumulation and inositol trisphosphate- or cyclic ADP-ribose-mediated release of Ca2+ from the nuclear envelope. Cell 80: 439-444.
42. Malviya AN, Rogue P, Vincendon G (1990) Stereospecific inositol 1,4,5- [32P] trisphosphate binding to isolated rat liver nuclei: evidence for inositol trisphosphate receptor-mediated calcium release from the nucleus. Proc Natl Acad Sci USA 87: 9270-9274.
43. Stehno-Bittel L, Perez-Terzic C, Clapham DE (1995) Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca2+ store. Science 270: 1835-1838.
44. Echevarría W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH (2003) Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nat Cell Biol 5: 440-446.
45. Santella L, Kyozuka K (1997) Effects of 1-methyladenine on nuclear Ca2+ transients and meiosis resumption in starfish oocytes are mimicked by the nuclear injection of inositol 1,4,5-trisphosphate and cADP-ribose. Cell Calcium 22: 11-20.
46. Cocco L, Gilmour RS, Ognibene A, Letcher AJ, Manzoli FA, et al. (1987) Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation. Biochem J 248: 765-770.
47. Martelli AM, Gilmour RS, Bertagnolo V, Neri LM, Manzoli L, et al. (1992) Nuclear localization and signalling activity of phosphoinositidase C beta in Swiss 3T3 cells. Nature 358: 242-245.
48. Guatimosim S, Amaya MJ, Guerra MT, Aguiar CJ, Goes AM, et al. (2008) Nuclear Ca2+ regulates cardiomyocyte function. Cell Calcium 44: 230-242.
49. Koppler P, Matter N, Malviya AN (1993) Evidence for stereospecific inositol 1,3,4,5-[3H]tetrakisphosphate binding sites on rat liver nuclei. Delineating inositol 1,3,4,5-tetrakisphosphate interaction in nuclear calcium signaling process. J Biol Chem 268: 26248-26252.
50. Mak DO, Foskett JK (1994) Single-channel inositol 1,4,5-trisphosphate receptor currents revealed by patch clamp of isolated Xenopus oocyte nuclei. J Biol Chem 269: 29375-29378.
51. Malviya AN (1994) The nuclear inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate receptors. Cell Calcium 16: 301-313.
52. Stehno-Bittel L, Lückhoff A, Clapham DE (1995) Calcium release from the nucleus by InsP3 receptor channels. Neuron 14: 163-167.
53. Roderick HL, Cook SJ (2008) Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival. Nat Rev Cancer 8: 361-375.
54. Lagoudakis L, Garcin I, Julien B, Nahum K, Gomes DA, et al. (2010) Cytosolic calcium regulates liver regeneration in the rat. Hepatology 52: 602-611.
55. Severin E, Kronholz HL, Köhnlein W, Göhde W (2005) Dosimetry of soft x-rays in thin liquid layers. Phys Med Biol 50: 1459-1467.
56. Bewes JM, Suchowerska N, Jackson M, Zhang M, McKenzie DR (2008) The radiobiological effect of intra-fraction dose-rate modulation in intensity modulated radiation therapy (IMRT). Phys Med Biol 53: 3567-3578.
57. Nowsheen S, Bonner JA, Lobuglio AF, Trummell H, Whitley AC, et al. (2011) Cetuximab augments cytotoxicity with poly (adp-ribose) polymerase inhibition in head and neck cancer. PLoS One 6: e24148.
58. Kornfeld JW, Meder S, Wohlberg M, Friedrich RE, Rau T, et al. (2011) Overexpression of TACE and TIMP3 mRNA in head and neck cancer: association with tumour development and progression. Br J Cancer 104:138-145.
59. Pusl T, Wu JJ, Zimmerman TL, Zhang L, Ehrlich BE, et al. (2002) Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium. J Biol Chem 277: 27517-27527.
60. Nestor M, Sundström M, Anniko M, Tolmachev V (2011) Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas. Nucl Med Biol 38: 103-112.
61. Witters L, Scherle P, Friedman S, Fridman J, Caulder E, et al. (2008) Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor. Cancer Res 68: 7083-7089.