Toxic effects of Carthamus tinctorius L. (Safflower) extract on mouse spermatogenesis

Journal of Assisted Reproduction and Genetics

Volumn 29, Issue 5, 2012, Pages 457-461

  Mirhoseini, Mehri ^a   Mohamadpour, Masoomeh ^a   Khorsandi, Layasadat ^a  

^a AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Carthamus tinctorius L. (safflower) extract; Mice; Spermatogenesis

Indexed keywords

SAFFLOWER EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELL VACUOLE; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL ANIMAL; GERM LAYER; GERM LINE; GIANT CELL; HISTOPATHOLOGY; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SAFFLOWER; SEMINIFEROUS TUBULE; SPERMATOGENESIS; SPERMATOZOON MATURATION; TESTIS;

ANIMALS; CARTHAMUS TINCTORIUS; EPITHELIUM; MALE; MICE; PLANT EXTRACTS; SPERMATOGENESIS; TESTIS;

CARTHAMUS TINCTORIUS; MUS;

EID: 84863204096     PISSN: 10580468     EISSN: 15737330     Source Type: Journal    
DOI: 10.1007/s10815-012-9734-x     Document Type: Article

References (28)

1. Franca LR, Ghosh S, Ye SJ, Russell LD. Surface and surface to volume relationships of the Sertoli cells during the cycle of the seminiferous epithelium in the rat. Biol Reprod. 1993;49(6):1215-28. (Pubitemid 23342114)
2. Boekelheide K, Fleming SL, Johnson KJ, Patel SR, Schoenfeld HA. Role of Sertoli cells in injury-associated testicular germ cell apoptosis. Exp Biol Med. 2000;225(2):105-15.
3. Cheng CY, Mruk DD. Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development. Physiol Rev. 2002;82(4):825-74.
4. Chen XW, Serag ES, Sneed KB, Zhou SF. Herbal bioactivation, molecular targets and the toxicity relevance. Chem Biol Interact 2011;15:192(3):161-76.
5. Emongor V. Safflower (Carthamus tinctorius L.) the underutilized and neglected crop: a review. Asian J Plant Sci. 2010;9:299-306.
6. Han SY, Li HX, Ma X, Zhang K, Ma ZZ, Tu PF. Protective effects of purified safflower extract on myocardial ischemia in vivo and in vitro. Phytomedicine. 2009;16(8):694-702.
7. Hiramatsu M, Takahashi T, Komatsu M, Kido T, Kasahara Y. Antioxidant and neuroprotective activities of Mogami-benibana (safflower, Carthamus tinctorius Linne). Neurochem Res. 2009;34(4):795-805.
8. Loo WTY, Cheung MNB, Chow LWC. The inhibitory effect of an herbal formula comprising ginseng and carthamus tinctorius on breast cancer. Life Sci. 2004;76(2):191-200. (Pubitemid 39425224)
9. Liu Z, Li C, Li M, Li D, Liu K. The subchronic toxicity of hydroxysafflor yellow A of 90 days repeatedly intraperitoneal injections in rats. Toxicology. 2004;203(1-3):139-43. (Pubitemid 39200944)
10. Nobakht M, Fattahi M, Hoormand M, Milanian I, Rahbar N, Mahmoudian M. A study on the teratogenic and cytotoxic effects of safflower extract. J Ethnopharmacol. 2000;73(3):453-9.
11. Igarashi K, Demachi A, Takenaka A. Protective effects of hot water extract of safflower leaves and its component luteolin-7-Oglucoside on paraquat-induced oxidative stress in rats. Food Sci Technol Res. 2001;7:224-30. (Pubitemid 33671838)
12. D'Cruz OJ, Uckun FM. Vanadocene-mediated in vivo male germ cell apoptosis. Toxicol Appl Pharmacol. 2000;166(3):186-95. (Pubitemid 30640629)
13. Oatley JM, Tibary A, de-Avila DM, Wheaton JE, McLean DJ, Reeves JJ. Changes in spermatogenesis and endocrine function in the ram testis due to irradiation and active immunization against luteinizing hormone-releasing hormone. J Anim Sci. 2005;83 (3):604-12. (Pubitemid 43324069)
14. Ma YH, Hu JH, Zhou XG, Mei ZT, Fei J, Guo LH. Gammaaminobutyric acid transporter (GAT1) overexpression in mouse affects the testicular morphology. Cell Res. 2000;10(1):59-69.
15. Orazizadeh M, Khorsandi LS, Hashemitabar M. Toxic effects of dexamethasone on mouse testicular germ cells. Andrologia. 2010;42(4):247-53.
16. Johnsen SG. Testicular biopsy score count: a method for registration of spermatogenesis in human testis. Hormones. 1970;1:2-25.
17. Takayama S, Akaike M, Kawashima K, Takahashi M, Kurokawa Y. A collaborative study in Japan on optimal treatment period and parameters for detection of male fertility disorders induced by drugs in rats. Int J Toxicol. 1995;14:266-92.
18. Ahmadian H, Ghanbari M, Moradi MR, Khaje-Dalouee M. Effect of cigarette smoke on spermatogenesis in rats. Urol J. 2007;4 (3):159-63.
19. Hild SA, Reel JR, Dykstra MJ, Mann PC, Marshall GR. Acute adverse effects of the indenopyridine CDB-4022 on the ultrastructure of sertoli cells, spermatocytes, and spermatids in rat testes: comparison to the known sertoli cell toxicant Di-n-pentylphthalate (DPP). J Androl. 2007;28(4):621-9. (Pubitemid 47057046)
20. Lee KP, Frame SR, Sykes GP, Valentine R. Testicular degeneration and spermatid retention in young rats. Toxicol Pathol. 1993;21 (3):292-302. (Pubitemid 23285224)
21. Hew KW, Ericson WA, Michael JW. A single low cadmium dose causes failure of spermiation in the rat. Toxicol Appl Pharmacol. 1993;121(1):15-21. (Pubitemid 23221268)
22. de Souza Predes F, Diamante MA, Dolder H. Testis response to low doses of cadmium in Wistar rats. Int J Exp Pathol. 2010;91 (2):125-31.
23. Yari A, Asadi MH, Bahadoran H, Dashtnavard H, Imani H, Naghii MR. Cadmium toxicity in spermatogenesis and protective effects of L-Carnitine in adult male rats. Biol Trace Elem Res. 2010;137 (2):216-25.
24. Russell L, Griswold M. Sertoli cell toxicants. In: Russell L, Griswold M, editors. The Sertoli cell. Florida: Cache River; 1995.
25. Neumann F, Schenck B. Formal genesis of giant cells in the germinal epithelium in the rat thioglucose model. Andrologia. 1977;9(4):323-8. (Pubitemid 8229258)
26. Moffit JS, Bryant BH, Hall SJ, Hall SJ. Dose-dependent effects of Sertoli cell toxicants 2, 5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis. Toxicol Pathol. 2007;35 (5):719-27.
27. Boekelheide K. Mechanisms of toxic damage to spermatogenesis. J Natl Cancer Inst Monogr. 2005;34:6-8.
28. Suzuki K, Tsubaki S, Fujita M, Koyama N, Takabashi M, Takazawa K. Effects of safflower seed extract on arterial stiffness. Vasc Health Risk Manag. 2010;6:1007-14.