Effects of saffower seed extract on arterial stiffness

Vascular Health and Risk Management

Volumn 6, Issue 1, 2010, Pages 1007-1014

  Suzuki, Katsuya ^a   Tsubaki, Shigekazu ^b   Fujita, Masami ^c   Koyama, Naoto ^a   Takahashi, Michio ^a   Takazawa, Kenji ^d  

^a AJINOMOTO CO INC   (Japan)

^b Samoncho Clinic   (Japan)

^c Shinanozaka Clinic   (Japan)

^d TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Antioxidants; Augmentation index; Pulse wave velocity; Saffower; Serotonin derivatives

Indexed keywords

AUTOANTIBODY; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERCELLULAR ADHESION MOLECULE 1; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; PLACEBO; SAFFLOWER EXTRACT; TRIACYLGLYCEROL; VASCULAR CELL ADHESION MOLECULE 1; LOW DENSITY LIPOPROTEIN; PLANT EXTRACT; SAFFLOWER OIL;

ADULT; AGED; ANTIBODY TITER; ARTERIAL STIFFNESS; ARTICLE; BORDERLINE HYPERTENSION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PLANT SEED; POSTMENOPAUSE; PULSE WAVE; SYSTOLIC BLOOD PRESSURE; ANKLE; ARTERY; ATHEROSCLEROTIC PLAQUE; BLOOD; BLOOD PRESSURE; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; HYPERTENSION; MIDDLE AGED; PATHOPHYSIOLOGY; PULSATILE FLOW; SAFFLOWER; TREATMENT OUTCOME; VASCULARIZATION;

ADULT; AGED; ANKLE; ARTERIES; BLOOD PRESSURE; CARTHAMUS TINCTORIUS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERTENSION; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; PLACEBOS; PLANT EXTRACTS; PLAQUE, ATHEROSCLEROTIC; POSTMENOPAUSE; PULSATILE FLOW; SAFFLOWER OIL; SEEDS; TREATMENT OUTCOME;

EID: 80051905776     PISSN: 11766344     EISSN: 11782048     Source Type: Journal    
DOI: 10.2147/VHRM.S13998     Document Type: Article

References (33)

1. Bae SJ, Shim SM, Park YJ, Lee JY, Chang EJ, Choi SW. Cytotoxicity of phenolic compounds isolated from seeds of saffower (Carthamus tinctorius L.) on cancer cell lines. Food Sci Biotechnol. 2002;11(2): 140-146.
2. Inamdar V, Chimmad B V, Naik R. Nutrient composition of traditional festival foods of north Karnataka. J Hum Ecol. 2005;18(1):43-48.
3. Zhang HL, Nagatsu A, Watanabe T, Sakakibara J, Okuyama H. Anti-oxidative compounds isolated from seeds of saffower (Carthamus tinctorius L.) oil cake. Chem Pharm Bull. 1997;45(12):1910-1914.
4. Cho SH, Lee HR, Kim TH, Choi SW, Lee WJ, Choi Y. Effects of defatted saffower seed extract and phenolic compounds in diet on plasma and liver lipid ovariectomized rats fed high-cholesterol diets. J Nutr Sci Vitaminol. 2004;50(1):32-37.
5. Koyama N, Kuribayashi K, Seki T, et al. Serotonin derivatives, major saffower (Carthamus tinctorius L.) seed antioxidants, inhibit low-density lipoprotein (LDL) oxidation and atherosclerosis in apolipoprotein E-deficient mice. J Agric Food Chem. 2006;54(14):4970-4976.
6. Nagatsu A, Zhang HL, Mizukami H, et al. Tyrosinase inhibitory and anti-tumor promoting activities of compounds isolated from saffower (Carthamus tinctorius L.) and cotton (Gossypium hirsutum L.) oil cakes. Nat Prod Lett. 2000;14(3):153-158.
7. Takii T, Hayashi M, Hiroma H, et al. Serotonin derivatives, N-(p-coumaroyl) serotonin, isolated from saffower (Carthamus tinctorius L.) oil cake augments the proliferation of normal human and mouse fibro-blasts in synergy with basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). J Biochem. 1999;125(5):910-915.
8. Hotta Y, Nagatsu A, Liu W, et al. Protective effects of antioxidative serotonin derivatives isolated from saffower against postischemic myocardial dysfunction. Mol Cell Biochem. 2002;238(1-2):151-162.
9. Katsuda S, Suzuki K, Koyama N, et al. Saffower seed polyphenols (N-(p-coumaroyl) serotonin and N-feruloylserotonin) ameliorate atherosclerosis and distensibility of the aortic wall in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Hypertens Res. 2009; 32(11):944-949.
10. Avolio AP, Chen SG, Wang RP, Zhang CL, Li MF, O'Rourke MF. Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation. 1983;68(1): 50-58.
11. Mattace-Raso FU, van der Cammen TJ, Hofman A, et al. Arterial stiffness and risk of coronary heart disease and stroke: The Rotterdam Study. Circulation. 2006;113(5):657-663.
12. Weber T, Auer J, O'Rourke M F, et al. Arterial stiffness, wave refections, and the risk of coronary artery disease. Circulation. 2004;109(2): 184-189.
13. Chirinos JA, Zambrano J P, Chakko S, et al. Aortic pressure augmentation predicts adverse cardiovascular events in patients with established coronary artery disease. Hypertension. 2005;45(5):980-985.
14. Takada H, Washino K, Harrell JS, Iwata H. Acceleration plethysmog-raphy to evaluate aging effect in cardiovascular system. Med Prog Technol. 1997;21(4):205-210.
15. Otsuka T, Kawada T, Katsumata M, Ibuki C. Utility of second derivative of the fnger photoplethysmogram for the estimation of the risk of coronary heart disease in the general population. Circ J. 2006;70(3): 304-310.
16. Takazawa K, Tanaka N, Fujita M, et al. Assessment of vasoactive agents and vascular aging by the second derivative of photoplethysmogram waveform. Hypertension. 1998;32(2):365-370.
17. Otuka T, Kawada T, Katsumata M, Ibuki C, Kusama Y. Independent determinants of second derivative of the finger photoplethysmogram among various cardiovascular risk factors in middle-aged men. Hypertens Res. 2007;30(12):1211-1218.
18. Koyama N, Suzuki K, Furukawa Y, et al. Effects of saffower seed extract supplementation on oxidation and cardiovascular risk markers in healthy human volunteers. Br J Nutr. 2008;101(4):568-575.
19. Yamashina A, Tomiyama H, Takeda K, et al. Validity, reproducibility and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res. 2002;25(3):359-364.
20. Funada J, Takata Y, Hashida H, et al. Dysfunctional central hemody-namic regulation after daily meal intake in metabolic syndrome. Atherosclerosis. 2010;210(1):268-273.
21. Bortolotto LA, Blacher J, Kondo T, Takazawa K, Safar ME. Assessment of vascular aging and atherosclerosis in hypertensive subjects: Second derivative of photoplethysmogram versus pulse wave velocity. Am J Hypertens. 2000;13(2):165-171.
22. Nakamura T, Fujii S, Hoshino J, et al. Selective angiotensin receptor antagonism with valsartan decreases arterial stiffness independently of blood pressure lowering in hypertensive patients. Hypertens Res. 2005; 28(12):937-943.
23. Sasamura H, Kitamura Y, Nakamura M, Ryuzaki M, Saruta T. Effects of the angiotensin receptor blocker candesartan on arterial stiffness and markers of extracellular matrix metabolism in patients with essential hypertension. Clin Exp Hypertens. 2006;28(5):511-520.
24. Kim SG, Ryu OH, Kim HY, et al. Effect of rosiglitazone on plasma adiponectin levels and arterial stiffness in subjects with prediabetes or non-diabetic metabolic syndrome. Eur J Endocrinol. 2006;154(3): 433-440.
25. Mita T, Watada H, Ogihara T, et al. Eicosapentanoic acid reduces the progression of carotid intima-media thickness in patients with Type 2 diabetes. Atherosclerosis. 2007;191(1):162-167.
26. Takada H, Washino K, Harrell JS, Iwata H. Acceleration plethysmog-raphy to evaluate aging effect in cardiovascular system. Med Prog Technol. 1996-1997;21(4):205-210.
27. Shirai Y, Ueno S, Ikeuchi K, Koizumi T, Mihara R. Pharmacokinetic study of N-feruloylserotonin and N-(p-coumaroyl)serotonin) in rats. Presented at: Third International Conference on Polyphenols and Health. Tokyo, Japan, 2007 Nov 25-28.
28. Kris-Etherton PM, Keen CL. Evidence that the antioxidant favonoid in tea and cocoa are benefcial for cardiovascular health. Curr Opin Lipidol. 2002;13(1):41-49.
29. Manach C, Mazur A, Scalbert A. Polyphenols and prevention of cardiovascular diseases. Curr Opin Lipidol. 2005;16(1):77-84.
30. Takimoto T, Arisaka H, Suzuki K, Murata T, Ozaki H, Koyama N. Antiatherosclerotic action of safflower seed polyphenols (N-(p-coumaroyl) serotonin), N-feruloylserotonin) on vascular smooth muscle cell [abstract]. J Clin Biochem Nutr. 2007;41 (Suppl):117.
31. Piga R, Naito Y, Kokura S, Yoshikawa T. Inhibitory effect of serotonin derivatives on high glucose-induced adhesion and migration of monocytes on human aortic endothelial cells. Br J Nutr. 2009;102(2): 264-272.
32. Wang X, Xie J, Zhang LJ, Hu DY, Luo YL, Wang JW. Reference values of brachial-ankle pulse wave velocity for Northern Chinese. Chin Med J. 2009;122(18):2103-2106.
33. Suzuki K, Koyama N, Sukegawa E, et al. Evaluation of safety of excessive intake of saffower seed extract dietary supplement in healthy adult subjects. Seikatsu Eisei. 2009;53(2):100-109.