Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC-EGFR dual inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 14, 2012, Pages 4405-4412

  Zuo, Miao ^a   Zheng, Yue Wen ^a   Lu, She Min ^a   Li, Yan ^a   Zhang, San Qi ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Antiproliferative activity; EGFR inhibitor; HDAC inhibitor; N Aryl salicylamides; Synthesis

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; N (3 CHLORO 4 FLUOROPHENYL) 2 HYDROXY 5 (7 HYDROXYAMINO 7 OXOHEPTANAMIDO) 4 METHOXYBENZAMIDE; N (3 CHLORO 4 FLUOROPHENYL) 2 HYDROXYL 5 (7 HYDROXYAMINO 7 OXOHEPTANAMIDO)BENZAMIDE; N (3 ETHYNYLPHENYL) 2 HYDROXY 5 (7 HYDROXYAMINO 7 OXOHEPTANAMIDO) 4 METHOXYBENZAMIDE; N (3 ETHYNYLPHENYL) 2 HYDROXY 5 (7 HYDROXYAMINO 7 OXOHEPTANAMIDO)BENZAMIDE; N (3 ETHYNYLPHENYL) 2 HYDROXY 5 (7 HYDROXYAMINO 7 OXOHEPTYLOXY)BENZAMIDE; N (3 ETHYNYLPHENYL) 2 HYDROXY 5 (8 HYDROXYAMINO 8 OXOOCTANAMIDO)BENZAMIDE; N (3 ETHYNYLPHENYL) 5 (7 HYDROXYAMINO 7 OXOHEPTANAMIDO) 2 METHOXYBENZAMIDE; N (3 FLUOROPHENYL) 2 HYDROXY 5 (7 HYDROXYAMINO 7 OXOHEPTANAMIDO)BENZAMIDE; N (3 TRIFLUOROMETHYLPHENYL) 2 HYDROXY 5 (7 HYDROXYAMINO 7 OXOHEPTANAMIDO)BENZAMIDE; N (3,4 DICHLOROPHENYL) 2 HYDROXY 5 (7 HYDROXYAMINO 7 OXOHEPTANAMIDO)BENZAMIDE; N (3,4 DIFLUOROPHENYL) 2 HYDROXY 5 (7 HYDROXYAMINO 7 OXOHEPTANAMIDO)BENZAMIDE; N (4 CHLORO 3 TRIFLUOROMETHYLPHENYL) 2 HYDROXY 5 (7 HYDROXYAMINO 7 OXOHEPTANAMIDO)BENZAMIDE; N [3 CHLORO 4 (3 FLUOROBENZYLOXY)PHENYL] 2 HYDROXY 5 (7 HYSROXYAMINO 7 OXOHEPTANAMIDO)BENZAMIDE; N PHENYL 2 HYDROXY 5 (7 HYDROXYAMINO 7 OXOHEPTANAMIDO)BENZAMIDE; SALICYLAMIDE DERIVATIVE; UNCLASSIFIED DRUG; VORINOSTAT;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; CELL PROLIFERATION; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HL-60 CELLS; HUMANS; HYDROXAMIC ACIDS; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SALICYLAMIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863200918     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.034     Document Type: Article

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