Effects of hyperglycemia and effects of ketosis on cerebral perfusion, cerebral water distribution, and cerebral metabolism

Diabetes

Volumn 61, Issue 7, 2012, Pages 1831-1837

  Glaser, Nicole ^a   Ngo, Catherine ^a   Anderson, Steven ^a   Yuen, Natalie ^a   Trifu, Alexandra ^a   O'Donnell, Martha ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BICARBONATE; CHLORIDE; CREATINE; CREATINE PHOSPHATE; INSULIN; LACTIC ACID; N ACETYLASPARTIC ACID; PHOSPHATE; SODIUM;

ANIMAL EXPERIMENT; ARTICLE; BICARBONATE BLOOD LEVEL; BRAIN BLOOD FLOW; BRAIN CELL; BRAIN CORTEX; BRAIN METABOLISM; BRAIN PERFUSION; CELL SWELLING; CHLORIDE BLOOD LEVEL; CONTROLLED STUDY; DIABETIC KETOACIDOSIS; DIFFUSION WEIGHTED IMAGING; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PERFUSION WEIGHTED IMAGING; PH; PRIORITY JOURNAL; RAT; SODIUM BLOOD LEVEL;

ADENOSINE TRIPHOSPHATE; ANIMALS; ASPARTIC ACID; BRAIN EDEMA; CEREBRUM; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC KETOACIDOSIS; DIET, HIGH-FAT; HYPERGLYCEMIA; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHATES; PHOSPHOCREATINE; RATS; WATER;

EID: 84863198110     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1286     Document Type: Article

References (50)

1. Edge JA, Hawkins MM, Winter DL, Dunger DB. The risk and outcome of cerebral oedema developing during diabetic ketoacidosis. Arch Dis Child 2001;85:16-22
2. Glaser NS, Wootton-Gorges SL, Marcin JP, et al. Mechanism of cerebral edema in children with diabetic ketoacidosis. J Pediatr 2004;145:164-171 (Pubitemid 38993386)
3. Wooton-Gorges S, Buonocore M, Caltagirone R, Kuppermann N, Glaser N. Progressive decrease in N-acetylaspartate/creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: evidence for permanent brain injury. AJNR Am J Neuroradiol 2010;31:780-781
4. Ghetti S, Lee J, Holtpatrick C, DeMaster D, Glaser N. Diabetic ketoacidosis and memory impariment in children with Type 1 diabetes. J Pediatr 2009; 156:109-114
5. Glaser N, Yuen N, Anderson SE, Tancredi DJ, O'Donnell ME. Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide. Diabetes 2010;59:702-709
6. Yuen N, Anderson SE, Glaser N, Tancredi DJ, O'Donnell ME. Cerebral blood flow and cerebral edema in rats with diabetic ketoacidosis. Diabetes 2008;57:2588-2594
7. Lam TI, Anderson SE, Glaser N, O'Donnell ME. Bumetanide reduces cerebral edema formation in rats with diabetic ketoacidosis. Diabetes 2005;54:510-516
8. O'Donnell ME, Lam TI, Tran L, Anderson SE. The role of the blood-brain barrier Na-K-2Cl cotransporter in stroke. Adv Exp Med Biol 2004;559:67-75
9. Anderson SA, Carr LJ, Schierling TD, Kost GJ. Are age-related differences in response to myocardial ischemia and cardioplegia pH dependent? Biol Neonate 1994;65:25-35 (Pubitemid 24014524)
10. Wootton-Gorges SL, Buonocore MH, Kuppermann N, et al. Detection of cerebral beta-hydroxy butyrate, acetoacetate, and lactate on proton MR spectroscopy in children with diabetic ketoacidosis. AJNR Am J Neuroradiol 2005;26:1286-1291 (Pubitemid 43821987)
11. Fennell JS, Falls WF Jr. Streptozotocin nephrotoxicity: studies on the defect in renal tubular acidification. Clin Nephrol 1981;15:97-101 (Pubitemid 11101887)
12. Taubin H, Matz R. Cerebral edema, diabetes insipidus, and sudden death during the treatment of diabetic ketoacidosis. Diabetes 1968;17:108-109
13. Young E, Bradley RF. Cerebral edema with irreversible coma in severe diabetic ketoacidosis. N Engl J Med 1967;276:665-669
14. Kucharczyk J, Moseley M, Kurhanewicz J, Norman D. MRS of ischemic/hypoxic brain disease. Invest Radiol 1989;24:951-954 (Pubitemid 20028606)
15. Auld KL, Ashwal S, Holshouser BA, et al. Proton magnetic resonance spectroscopy in children with acute central nervous system injury. Pediatr Neurol 1995;12:323-334
16. Alvarez-Sabín J, Molina CA, Ribó M, et al. Impact of admission hyperglycemia on stroke outcome after thrombolysis: risk stratification in relation to time to reperfusion. Stroke 2004;35:2493-2498 (Pubitemid 39458405)
17. Ennis SR, Keep RF. Effect of sustained-mild and transient-severe hyperglycemia on ischemia-induced blood-brain barrier opening. J Cereb Blood Flow Metab 2007;27:1573-1582 (Pubitemid 47301440)
18. Huang NC, Wei J, Quast MJ. A comparison of the early development of ischemic brain damage in normoglycemic and hyperglycemic rats using magnetic resonance imaging. Exp Brain Res 1996;109:33-42 (Pubitemid 26119963)
19. Parsons MW, Barber PA, Desmond PM, et al. Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study. Ann Neurol 2002;52:20-28 (Pubitemid 34693739)
20. Ribo M, Molina CA, Delgado P, et al. Hyperglycemia during ischemia rapidly accelerates brain damage in stroke patients treated with tPA. J Cereb Blood Flow Metab 2007;27:1616-1622 (Pubitemid 47301446)
21. Li PA, Shuaib A, Miyashita H, He QP, Siesjö BK, Warner DS. Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia. Stroke 2000;31:183-192 (Pubitemid 30035773)
22. Lin B, Ginsberg MD, Busto R, Li L. Hyperglycemia triggers massive neutrophil deposition in brain following transient ischemia in rats. Neurosci Lett 2000;278:1-4 (Pubitemid 30009882)
23. Zygun DA, Steiner LA, Johnston AJ, et al. Hyperglycemia and brain tissue pH after traumatic brain injury. Neurosurgery 2004;55:877-881; discussion 882
24. Potenza MA, Gagliardi S, Nacci C, Carratu' MR, Montagnani M. Endothelial dysfunction in diabetes: from mechanisms to therapeutic targets. Curr Med Chem 2009;16:94-112
25. Evan-Wong LA, Davidson RJ, Stowers JM. Alterations in erythrocytes in hyperosmolar diabetic decompensation: a pathophysiological basis for impaired blood flow and for an improved design of fluid therapy. Diabetologia 1985;28:739-742 (Pubitemid 16203775)
26. Sevick EM, Jain RK. Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia. Cancer Res 1991;51: 2727-2730
27. Duckrow RB, Beard DC, Brennan RW. Regional cerebral blood flow decreases during chronic and acute hyperglycemia. Stroke 1987;18:52-58 (Pubitemid 17016685)
28. Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 2001;32:2426-2432 (Pubitemid 32954818)
29. Poppe AY, Majumdar SR, Jeerakathil T, Ghali W, Buchan AM, Hill MD; Canadian Alteplase for Stroke Effectiveness Study Investigators. Admission hyperglycemia predicts a worse outcome in stroke patients treated with intravenous thrombolysis. Diabetes Care 2009;32:617-622
30. Wang Y, Lim LL, Levi C, Heller RF, Fisher J. Influence of hyperglycemia on stroke mortality. J Stroke Cerebrovasc Dis 2001;10:11-18 (Pubitemid 32151809)
31. Biessels GJ, Kamal A, Urban IJ, Spruijt BM, Erkelens DW, Gispen WH. Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment. Brain Res 1998;800:125-135 (Pubitemid 28361929)
32. Malone JI, Hanna S, Saporta S, et al. Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. Pediatr Diabetes 2008;9:531-539
33. Isales C, Min L, Hoffman W. Acetoacetate and B-hydroxybutyrate differentially regulate endothelin-1 and vascular endothelial growth factor in mouse brain microvascular endothelial cells. J Diab Comp 1999;13:91-97 (Pubitemid 29320015)
34. Jain SK, McVie R, Bocchini JA Jr. Hyperketonemia (ketosis), oxidative stress and type 1 diabetes. Pathophysiology 2006;13:163-170
35. Appelberg KS, Hovda DA, Prins ML. The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat. J Neurotrauma 2009;26:497-506
36. Prins ML. Cerebral metabolic adaptation and ketone metabolism after brain injury. J Cereb Blood Flow Metab 2008;28:1-16
37. Puchowicz MA, Zechel JL, Valerio J, et al. Neuroprotection in diet-induced ketotic rat brain after focal ischemia. J Cereb Blood Flow Metab 2008;28:1907-1916
38. Wing RR, Vazquez JA, Ryan CM. Cognitive effects of ketogenic weigh-treducing diets. Int J Obes Relat Metab Disord 1995;19:811-816
39. Zhao Q, Stafstrom CE, Fu DD, Hu Y, Holmes GL. Detrimental effects of the ketogenic diet on cognitive function in rats. Pediatr Res 2004;55:498-506 (Pubitemid 38240831)
40. Linde R, Hasselbalch SG, Topp S, Paulson OB, Madsen PL. Global cerebral blood flow and metabolism during acute hyperketonemia in the awake and anesthetized rat. J Cereb Blood Flow Metab 2006;26:170-180 (Pubitemid 43151574)
41. Bingham E, Hopkins D, Smith D, Pernet A, Hallett W, Reed L, et al. The role of insulin in human brain glucose metabolism: an 18fluoro-deoxyglucose positron emission tomography study. Diabetes 2002;51:3384-3390 (Pubitemid 35403440)
42. Hoyer S, Henneberg N, Knapp S, Lannert H, Martin E. Brain glucose metabolism is controlled by amplification and desensitization of the neuronal insulin receptor. Ann N Y Acad Sci 1996;777:374-379 (Pubitemid 26149217)
43. Doyle P, Cusin I, Rohner-Jeanrenaud F, Jeanrenaud B. Four-day hyper-insulinemia in euglycemic conditions alters local cerebral glucose utilization in specific brain nuclei of freely moving rats. Brain Res 1995;684:47-55
44. Collino M, Aragno M, Castiglia S, et al. Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta. Diabetes 2009;58:235-242
45. Haraldseth O, Jones RA, Skottner A. A quantitative in-vivo MR imaging study of brain dehydration in diabetic rats and rats treated with peptide hormones. Magn Reson Imaging 1997;15:203-210 (Pubitemid 27173234)
46. Wickelgren I. Tracking insulin to the mind. Science 1998;280:517-519 (Pubitemid 28227733)
47. Cardoso S, Correia S, Santos RX, et al. Insulin is a two-edged knife on the brain. J Alzheimers Dis 2009;18:483-507
48. Schulingkamp RJ, Pagano TC, Hung D, Raffa RB. Insulin receptors and insulin action in the brain: review and clinical implications. Neurosci Biobehav Rev 2000;24:855-872
49. Salkovic-Petrisic M, Osmanovic J, Grünblatt E, Riederer P, Hoyer S. Modeling sporadic Alzheimer's disease: the insulin resistant brain state generates multiple long-term morphobiological abnormalities including hyperphosphorylated tau protein and amyloid-beta. J Alzheimers Dis 2009;18:729-750
50. Duarte AI, Proença T, Oliveira CR, Santos MS, Rego AC. Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress. Diabetes 2006;55:2863-2870 (Pubitemid 44923688)