Discovery of GNF-5837, a selective TRK inhibitor with efficacy in rodent cancer tumor models

ACS Medicinal Chemistry Letters

Volumn 3, Issue 2, 2012, Pages 140-145

  Albaugh, Pam ^a   Fan, Yi ^a   Mi, Yuan ^a   Sun, Fangxian ^a   Adrian, Francisco ^a   Li, Nanxin ^a   Jia, Yong ^a   Sarkisova, Yelena ^a   Kreusch, Andreas ^a   Hood, Tami ^a   Lu, Min ^a   Liu, Guoxun ^a   Huang, Shenlin ^a   Liu, Zuosheng ^a   Loren, Jon ^a   Tuntland, Tove ^a   Karanewsky, Donald S ^a   Seidel, H Martin ^a   Molteni, Valentina ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

GNF 5837; neurotrophins; NGF; oxindole; TRK; tropomyosin receptor kinase

Indexed keywords

ANTINEOPLASTIC AGENT; GNF 5837; PHOSPHOTRANSFERASE INHIBITOR; TROPOMYOSIN RECEPTOR KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; IN VIVO STUDY; MALE; MOUSE; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; THERAPY EFFECT; TUMOR XENOGRAFT;

RODENTIA;

EID: 84863179654     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200261d     Document Type: Article

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