Toxicokinetics of naringin and its metabolite naringenin after 180-day repeated oral administration in beagle dogs assayed by a rapid resolution liquid chromatography/tandem mass spectrometric method

Journal of Asian Natural Products Research

Volumn 14, Issue 1, 2012, Pages 68-75

  Yang, Cui Ping ^a   Liu, Meng Hua ^a,b   Zou, Wei ^a   Guan, Xiao Ling ^c   Lai, Li ^c   Su, Wei Wei ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Guangdong Medi world Pharmaceutical Co Ltd   (China)

^c National Chengdu Center for Safety Evaluation of Drugs   (China)

Author keywords

beagle dogs; naringenin; naringin; toxicokinetics

Indexed keywords

AURANTIIN; NARINGENIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DOG; DRUG BLOOD LEVEL; DRUG EXPOSURE; DRUG HALF LIFE; DRUG SAFETY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; REPEATED DRUG DOSE; TANDEM MASS SPECTROMETRY; TOXICOKINETICS;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, LIQUID; CITRUS; DOGS; FEMALE; FLAVANONES; MALE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

CANIS FAMILIARIS;

EID: 84863143923     PISSN: 10286020     EISSN: 14772213     Source Type: Journal    
DOI: 10.1080/10286020.2011.632369     Document Type: Article

References (23)

1. Nogata, Y., Sakamoto, K., Shiratsuchi, H., Ishii, T., Yano, M., and, Ohta, H. 2006. Biotechnol. Biochem., 70: 178
2. Chinese Pharmacopoeia Commission. 2010. Pharmacopoeia of the People's Republic of China, Vol. 1, Beijing, China: China Medical Science Press.
3. Chen, Y.T., Zheng, R.L., Jia, Z.J., and, Ju, Y. 1990. Free Radic. Biol. Med., 9: 19
4. Jeon, S.M., Park, Y.B., and, Choi, M.S. 2004. Clin. Nutr., 23: 1025
5. Lambev, I., Krushkov, I., Zheliazkov, D., and, Nikolov, N. 1980. Eksp. Med. Morfol., 19: 207
6. Lee, C.H., Jeong, T.S., Choi, Y.K., Hyun, B.H., Oh, G.T., Kim, E.H., Kim, J.R., Han, J.I., and, Bok, S.H. 2001. Biochem. Biophys. Res. Commum., 284: 681
7. Martin, M.J., Marhuenda, E., Pérez-Guerrero, C., and, Franco, J.M. 1994. Pharmacology, 49: 144
8. Schindler, R., and, Mentlein, R. 2006. J. Nutr., 136: 1477
9. Felgines, C., Texier, O., Morand, C., Manach, C., Scalbert, A., Régerat, F., and, Rémésy, C. 2000. Am. J. Physiol. Gastrointest. Liver Physiol., 279: 1148
10. Fang, T.Z., Wang, Y.G., Ma, Y., Su, W.W., Bai, Y., and, Zhao, P.Y. 2006. J. Pharm. Biomed. Anal., 40: 454
11. Li, X.H., Xiong, Z.L., Lu, S., Zhang, Y., and, Li, F.M. 2010. Chin. J. Nat. Med., 8: 40
12. Hsiu, S.L., Huang, T.Y., Hou, Y.C., Chin, D.H., and, Lee Chao, P.D. 2002. Life Sci., 70: 1481
13. Mata-Bilbao, M. de L., Andrés-Lacueva, C., Roura, E., Jáuregui, O., Escribano, E., Torre, C., and, Lamuela-Raventós, R.M. 2007. Br. J. Nutr., 98: 86
14. Ishii, K., Furuta, T., and, Kasuya, Y. 1996. J. Chromatogr. B, 683: 225
15. Ishii, K., Furuta, T., and, Kasuya, Y. 1997. J. Chromatogr. B, 704: 299
16. Renugadevi, J., and, Prabu, S.M. 2010. Exp. Toxicol. Pathol., 62: 171
17. Su, W.W., Wang, Y.G., Fang, T.Z., Peng, W., and, Wu, Z. 2009. European Patent.,. No. 1591123
18. Li, P.B., Ma, Y., Wang, Y.G., and, Su, W.W. 2006. Zhongguo Zhong Yao Za Zhi, 16: 1350
19. Li, P.B., Su, C., Bi, F.J., Wang, Y.G., Peng, W., and, Su, W.W. 2008. Zhong Cao Yao, 39: 247
20. Lin, B.Q., Li, P.B., Wang, Y.G., Peng, W., Wu, Z., Su, W.W., and, Ji, H. 2008. Pulm. Pharmacol. Ther., 21: 259
21. Gao, S., Li, P.B., Yang, H.L., Fang, S.Q., and, Su, W.W. 2011. Planta Med., 77: 16
22. Manach, C., Scalbert, A., Morand, C., Remesy, C., and, Jimenez, L. 2004. Am. J. Clin. Nutr., 79: 727
23. Sun, N., Lu, G.C., Lin, M., Fan, G.R., and, Wu, Y.T. 2009. Environ. Toxicol. Pharmacol., 27: 237