메뉴 건너뛰기




Volumn 7, Issue 6, 2012, Pages

The HyVac4 subunit vaccine efficiently boosts BCG-primed anti-mycobacterial protective immunity

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE; BCG VACCINE; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; H4 VACCINE; IC 31; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84863109492     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039909     Document Type: Article
Times cited : (89)

References (44)
  • 2
    • 0036467798 scopus 로고    scopus 로고
    • Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33 years of latent infection
    • Lillebaek T, Dirksen A, Baess I, Strunge B, Thomsen VO, et al. (2002) Molecular evidence of endogenous reactivation of Mycobacterium tuberculosis after 33 years of latent infection. J Infect Dis 185: 401-404.
    • (2002) J Infect Dis , vol.185 , pp. 401-404
    • Lillebaek, T.1    Dirksen, A.2    Baess, I.3    Strunge, B.4    Thomsen, V.O.5
  • 4
    • 0028872014 scopus 로고
    • Variation in protection by BCG: implications of and for heterologous immunity
    • Fine PE, (1995) Variation in protection by BCG: implications of and for heterologous immunity. Lancet 346: 1339-1345.
    • (1995) Lancet , vol.346 , pp. 1339-1345
    • Fine, P.E.1
  • 5
    • 27744524915 scopus 로고    scopus 로고
    • Memory T lymphocytes generated by Mycobacterium bovis BCG vaccination reside within a CD4 CD44lo CD62 Ligandhi population
    • Kipnis A, Irwin S, Izzo AA, Basaraba RJ, Orme IM, (2005) Memory T lymphocytes generated by Mycobacterium bovis BCG vaccination reside within a CD4 CD44lo CD62 Ligandhi population. Infect Immun 73: 7759-7764.
    • (2005) Infect Immun , vol.73 , pp. 7759-7764
    • Kipnis, A.1    Irwin, S.2    Izzo, A.A.3    Basaraba, R.J.4    Orme, I.M.5
  • 7
    • 0031939337 scopus 로고    scopus 로고
    • Does the efficacy of BCG decline with time since vaccination?
    • Sterne JA, Rodrigues LC, Guedes IN, (1998) Does the efficacy of BCG decline with time since vaccination? Int J Tuberc Lung Dis 2: 200-207.
    • (1998) Int J Tuberc Lung Dis , vol.2 , pp. 200-207
    • Sterne, J.A.1    Rodrigues, L.C.2    Guedes, I.N.3
  • 8
    • 12444284630 scopus 로고    scopus 로고
    • Rates of adverse reactions to first and second doses of BCG vaccination: results of a large community trial in Brazilian schoolchildren
    • Dourado I, Rios MH, Pereira SM, Cunha SS, Ichihara MY, et al. (2003) Rates of adverse reactions to first and second doses of BCG vaccination: results of a large community trial in Brazilian schoolchildren. Int J Tuberc Lung Dis 7: 399-402.
    • (2003) Int J Tuberc Lung Dis , vol.7 , pp. 399-402
    • Dourado, I.1    Rios, M.H.2    Pereira, S.M.3    Cunha, S.S.4    Ichihara, M.Y.5
  • 9
    • 77950576587 scopus 로고    scopus 로고
    • Effect of revaccination with BCG in early childhood on mortality: randomised trial in Guinea-Bissau
    • Roth AE, Benn CS, Ravn H, Rodrigues A, Lisse IM, et al. (2010) Effect of revaccination with BCG in early childhood on mortality: randomised trial in Guinea-Bissau. BMJ 340: c671.
    • (2010) BMJ , vol.340
    • Roth, A.E.1    Benn, C.S.2    Ravn, H.3    Rodrigues, A.4    Lisse, I.M.5
  • 10
    • 45649084244 scopus 로고    scopus 로고
    • Consequence of prior exposure to environmental mycobacteria on BCG vaccination and diagnosis of tuberculosis infection
    • Thom M, Howard C, Villarreal-Ramos B, Mead E, Vordermeier M, et al. (2008) Consequence of prior exposure to environmental mycobacteria on BCG vaccination and diagnosis of tuberculosis infection. Tuberculosis (Edinb) 88: 324-334.
    • (2008) Tuberculosis (Edinb) , vol.88 , pp. 324-334
    • Thom, M.1    Howard, C.2    Villarreal-Ramos, B.3    Mead, E.4    Vordermeier, M.5
  • 11
    • 33845455460 scopus 로고    scopus 로고
    • Exposure to Mycobacterium avium can modulate established immunity against Mycobacterium tuberculosis infection generated by Mycobacterium bovis BCG vaccination
    • Flaherty DK, Vesosky B, Beamer GL, Stromberg P, Turner J, (2006) Exposure to Mycobacterium avium can modulate established immunity against Mycobacterium tuberculosis infection generated by Mycobacterium bovis BCG vaccination. J Leukoc Biol 80: 1262-1271.
    • (2006) J Leukoc Biol , vol.80 , pp. 1262-1271
    • Flaherty, D.K.1    Vesosky, B.2    Beamer, G.L.3    Stromberg, P.4    Turner, J.5
  • 12
    • 0036153758 scopus 로고    scopus 로고
    • Failure of the Mycobacterium bovis BCG vaccine: some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis
    • Brandt L, Feino Cunha J, Weinreich Olsen A, Chilima B, Hirsch P, et al. (2002) Failure of the Mycobacterium bovis BCG vaccine: some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis. Infect Immun 70: 672-678.
    • (2002) Infect Immun , vol.70 , pp. 672-678
    • Brandt, L.1    Feino Cunha, J.2    Weinreich Olsen, A.3    Chilima, B.4    Hirsch, P.5
  • 13
    • 0026542251 scopus 로고
    • Immunization of mice with mycobacterial culture filtrate proteins
    • Hubbard RD, Flory CM, Collins FM, (1992) Immunization of mice with mycobacterial culture filtrate proteins. Clin Exp Immunol 87: 94-98.
    • (1992) Clin Exp Immunol , vol.87 , pp. 94-98
    • Hubbard, R.D.1    Flory, C.M.2    Collins, F.M.3
  • 14
    • 0028290569 scopus 로고
    • Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins
    • Andersen P, (1994) Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins. Infect Immun 62: 2536-2544.
    • (1994) Infect Immun , vol.62 , pp. 2536-2544
    • Andersen, P.1
  • 15
    • 0026027849 scopus 로고
    • T-cell proliferative response to antigens secreted by Mycobacterium tuberculosis
    • Andersen P, Askgaard D, Ljungqvist L, Bentzon MW, Heron I, (1991) T-cell proliferative response to antigens secreted by Mycobacterium tuberculosis. Infect Immun 59: 1558-1563.
    • (1991) Infect Immun , vol.59 , pp. 1558-1563
    • Andersen, P.1    Askgaard, D.2    Ljungqvist, L.3    Bentzon, M.W.4    Heron, I.5
  • 16
    • 0035055282 scopus 로고    scopus 로고
    • Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6
    • Olsen AW, van Pinxteren LA, Okkels LM, Rasmussen PB, Andersen P, (2001) Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6. Infect Immun 69: 2773-2778.
    • (2001) Infect Immun , vol.69 , pp. 2773-2778
    • Olsen, A.W.1    van Pinxteren, L.A.2    Okkels, L.M.3    Rasmussen, P.B.4    Andersen, P.5
  • 17
    • 4644235020 scopus 로고    scopus 로고
    • Protective effect of a tuberculosis subunit vaccine based on a fusion of antigen 85B and ESAT-6 in the aerosol guinea pig model
    • Olsen AW, Williams A, Okkels LM, Hatch G, Andersen P, (2004) Protective effect of a tuberculosis subunit vaccine based on a fusion of antigen 85B and ESAT-6 in the aerosol guinea pig model. Infect Immun 72: 6148-6150.
    • (2004) Infect Immun , vol.72 , pp. 6148-6150
    • Olsen, A.W.1    Williams, A.2    Okkels, L.M.3    Hatch, G.4    Andersen, P.5
  • 18
    • 78751676191 scopus 로고    scopus 로고
    • First in humans: A new molecularly defined vaccine shows excellent safety and strong induction of long-lived Mycobacterium tuberculosis-specific Th1-cell like responses
    • Ottenhoff TH, Doherty TM, Dissel JT, Bang P, Lingnau K, et al. (2010) First in humans: A new molecularly defined vaccine shows excellent safety and strong induction of long-lived Mycobacterium tuberculosis-specific Th1-cell like responses. Hum Vaccin 6 (12): 1007-15.
    • (2010) Hum Vaccin , vol.6 , Issue.12 , pp. 1007-1015
    • Ottenhoff, T.H.1    Doherty, T.M.2    Dissel, J.T.3    Bang, P.4    Lingnau, K.5
  • 19
    • 0035840882 scopus 로고    scopus 로고
    • Comparison of a whole-blood interferon gamma assay with tuberculin skin testing for detecting latent Mycobacterium tuberculosis infection
    • Mazurek GH, LoBue PA, Daley CL, Bernardo J, Lardizabal AA, et al. (2001) Comparison of a whole-blood interferon gamma assay with tuberculin skin testing for detecting latent Mycobacterium tuberculosis infection. Jama 286: 1740-1747.
    • (2001) Jama , vol.286 , pp. 1740-1747
    • Mazurek, G.H.1    LoBue, P.A.2    Daley, C.L.3    Bernardo, J.4    Lardizabal, A.A.5
  • 20
    • 26244444869 scopus 로고    scopus 로고
    • Sensitivity of a new commercial enzyme-linked immunospot assay (T SPOT-TB) for diagnosis of tuberculosis in clinical practice
    • Meier T, Eulenbruch HP, Wrighton-Smith P, Enders G, Regnath T, (2005) Sensitivity of a new commercial enzyme-linked immunospot assay (T SPOT-TB) for diagnosis of tuberculosis in clinical practice. Eur J Clin Microbiol Infect Dis 24: 529-536.
    • (2005) Eur J Clin Microbiol Infect Dis , vol.24 , pp. 529-536
    • Meier, T.1    Eulenbruch, H.P.2    Wrighton-Smith, P.3    Enders, G.4    Regnath, T.5
  • 21
    • 18644373991 scopus 로고    scopus 로고
    • Exchanging ESAT6 with TB10.4 in an Ag85B fusion molecule-based tuberculosis subunit vaccine: efficient protection and ESAT6-based sensitive monitoring of vaccine efficacy
    • Dietrich J, Aagaard C, Leah R, Olsen AW, Stryhn A, et al. (2005) Exchanging ESAT6 with TB10.4 in an Ag85B fusion molecule-based tuberculosis subunit vaccine: efficient protection and ESAT6-based sensitive monitoring of vaccine efficacy. J Immunol 174: 6332-6339.
    • (2005) J Immunol , vol.174 , pp. 6332-6339
    • Dietrich, J.1    Aagaard, C.2    Leah, R.3    Olsen, A.W.4    Stryhn, A.5
  • 22
    • 67649961505 scopus 로고    scopus 로고
    • Protection and polyfunctional T cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen dose
    • Aagaard C, Hoang TT, Izzo A, Billeskov R, Troudt J, et al. (2009) Protection and polyfunctional T cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen dose. PLoS One 4: e5930.
    • (2009) PLoS One , vol.4
    • Aagaard, C.1    Hoang, T.T.2    Izzo, A.3    Billeskov, R.4    Troudt, J.5
  • 23
    • 77951757844 scopus 로고    scopus 로고
    • Difference in TB10.4 T-cell epitope recognition following immunization with recombinant TB10.4, BCG or infection with Mycobacterium tuberculosis
    • Billeskov R, Grandal MV, Poulsen C, Christensen JP, Winther N, et al. (2010) Difference in TB10.4 T-cell epitope recognition following immunization with recombinant TB10.4, BCG or infection with Mycobacterium tuberculosis. Eur J Immunol 40: 1342-1354.
    • (2010) Eur J Immunol , vol.40 , pp. 1342-1354
    • Billeskov, R.1    Grandal, M.V.2    Poulsen, C.3    Christensen, J.P.4    Winther, N.5
  • 24
    • 35748946039 scopus 로고    scopus 로고
    • Induction of CD8 T cells against a novel epitope in TB10.4: correlation with mycobacterial virulence and the presence of a functional region of difference-1
    • Billeskov R, Vingsbo-Lundberg C, Andersen P, Dietrich J, (2007) Induction of CD8 T cells against a novel epitope in TB10.4: correlation with mycobacterial virulence and the presence of a functional region of difference-1. J Immunol 179: 3973-3981.
    • (2007) J Immunol , vol.179 , pp. 3973-3981
    • Billeskov, R.1    Vingsbo-Lundberg, C.2    Andersen, P.3    Dietrich, J.4
  • 25
    • 34250303350 scopus 로고    scopus 로고
    • Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
    • Darrah PA, Patel DT, De Luca PM, Lindsay RW, Davey DF, et al. (2007) Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med 13: 843-850.
    • (2007) Nat Med , vol.13 , pp. 843-850
    • Darrah, P.A.1    Patel, D.T.2    de Luca, P.M.3    Lindsay, R.W.4    Davey, D.F.5
  • 26
    • 41149096579 scopus 로고    scopus 로고
    • T-cell quality in memory and protection: implications for vaccine design
    • Seder RA, Darrah PA, Roederer M, (2008) T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol 8: 247-258.
    • (2008) Nat Rev Immunol , vol.8 , pp. 247-258
    • Seder, R.A.1    Darrah, P.A.2    Roederer, M.3
  • 27
    • 33646586698 scopus 로고    scopus 로고
    • Expression levels of Mycobacterium tuberculosis antigen-encoding genes versus production levels of antigen-specific T cells during stationary level lung infection in mice
    • Rogerson BJ, Jung YJ, LaCourse R, Ryan L, Enright N, et al. (2006) Expression levels of Mycobacterium tuberculosis antigen-encoding genes versus production levels of antigen-specific T cells during stationary level lung infection in mice. Immunology 118: 195-201.
    • (2006) Immunology , vol.118 , pp. 195-201
    • Rogerson, B.J.1    Jung, Y.J.2    LaCourse, R.3    Ryan, L.4    Enright, N.5
  • 28
    • 0347511897 scopus 로고    scopus 로고
    • Stable T-cell population expressing an effector cell surface phenotype in the lungs of mice chronically infected with Mycobacterium tuberculosis
    • Junqueira-Kipnis AP, Turner J, Gonzalez-Juarrero M, Turner OC, Orme IM, (2004) Stable T-cell population expressing an effector cell surface phenotype in the lungs of mice chronically infected with Mycobacterium tuberculosis. Infect Immun 72: 570-575.
    • (2004) Infect Immun , vol.72 , pp. 570-575
    • Junqueira-Kipnis, A.P.1    Turner, J.2    Gonzalez-Juarrero, M.3    Turner, O.C.4    Orme, I.M.5
  • 29
    • 0036266656 scopus 로고    scopus 로고
    • Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis
    • Vordermeier HM, Chambers MA, Cockle PJ, Whelan AO, Simmons J, et al. (2002) Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis. Infect Immun 70: 3026-3032.
    • (2002) Infect Immun , vol.70 , pp. 3026-3032
    • Vordermeier, H.M.1    Chambers, M.A.2    Cockle, P.J.3    Whelan, A.O.4    Simmons, J.5
  • 30
    • 0036159751 scopus 로고    scopus 로고
    • Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients
    • Doherty TM, Demissie A, Olobo J, Wolday D, Britton S, et al. (2002) Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients. J Clin Microbiol 40: 704-706.
    • (2002) J Clin Microbiol , vol.40 , pp. 704-706
    • Doherty, T.M.1    Demissie, A.2    Olobo, J.3    Wolday, D.4    Britton, S.5
  • 31
    • 84858997919 scopus 로고    scopus 로고
    • Preclinical evidence for implementing a prime-boost vaccine strategy for tuberculosis
    • Brennan MJ, Clagett B, Fitzgerald H, Chen V, Williams A, et al. (2012) Preclinical evidence for implementing a prime-boost vaccine strategy for tuberculosis. Vaccine 30: 2811-2823.
    • (2012) Vaccine , vol.30 , pp. 2811-2823
    • Brennan, M.J.1    Clagett, B.2    Fitzgerald, H.3    Chen, V.4    Williams, A.5
  • 32
    • 80051716214 scopus 로고    scopus 로고
    • A booster vaccine expressing a latency-associated antigen augments BCG induced immunity and confers enhanced protection against tuberculosis
    • Dey B, Jain R, Gupta UD, Katoch VM, Ramanathan VD, et al. (2011) A booster vaccine expressing a latency-associated antigen augments BCG induced immunity and confers enhanced protection against tuberculosis. PLoS One 6: e23360.
    • (2011) PLoS One , vol.6
    • Dey, B.1    Jain, R.2    Gupta, U.D.3    Katoch, V.M.4    Ramanathan, V.D.5
  • 33
    • 60549091001 scopus 로고    scopus 로고
    • Immunogenicity and protective efficacy of prime-boost regimens with recombinant (delta)ureC hly+ Mycobacterium bovis BCG and modified vaccinia virus ankara expressing M. tuberculosis antigen 85A against murine tuberculosis
    • Tchilian EZ, Desel C, Forbes EK, Bandermann S, Sander CR, et al. (2009) Immunogenicity and protective efficacy of prime-boost regimens with recombinant (delta)ureC hly+ Mycobacterium bovis BCG and modified vaccinia virus ankara expressing M. tuberculosis antigen 85A against murine tuberculosis. Infect Immun 77: 622-631.
    • (2009) Infect Immun , vol.77 , pp. 622-631
    • Tchilian, E.Z.1    Desel, C.2    Forbes, E.K.3    Bandermann, S.4    Sander, C.R.5
  • 34
    • 58149314574 scopus 로고    scopus 로고
    • Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice
    • Forbes EK, Sander C, Ronan EO, McShane H, Hill AV, et al. (2008) Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice. J Immunol 181: 4955-4964.
    • (2008) J Immunol , vol.181 , pp. 4955-4964
    • Forbes, E.K.1    Sander, C.2    Ronan, E.O.3    McShane, H.4    Hill, A.V.5
  • 35
    • 40049094957 scopus 로고    scopus 로고
    • Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy
    • Pereyra F, Addo MM, Kaufmann DE, Liu Y, Miura T, et al. (2008) Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. J Infect Dis 197: 563-571.
    • (2008) J Infect Dis , vol.197 , pp. 563-571
    • Pereyra, F.1    Addo, M.M.2    Kaufmann, D.E.3    Liu, Y.4    Miura, T.5
  • 36
    • 77958475885 scopus 로고    scopus 로고
    • Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guerin vaccination of newborns
    • Kagina BM, Abel B, Scriba TJ, Hughes EJ, Keyser A, et al. (2010) Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guerin vaccination of newborns. Am J Respir Crit Care Med 182: 1073-1079.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 1073-1079
    • Kagina, B.M.1    Abel, B.2    Scriba, T.J.3    Hughes, E.J.4    Keyser, A.5
  • 37
    • 77956108181 scopus 로고    scopus 로고
    • Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection
    • Caccamo N, Guggino G, Joosten SA, Gelsomino G, Di Carlo P, et al. (2010) Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection. Eur J Immunol 40: 2211-2220.
    • (2010) Eur J Immunol , vol.40 , pp. 2211-2220
    • Caccamo, N.1    Guggino, G.2    Joosten, S.A.3    Gelsomino, G.4    Di Carlo, P.5
  • 38
    • 80052653924 scopus 로고    scopus 로고
    • Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load
    • Day CL, Abrahams DA, Lerumo L, Janse van Rensburg E, Stone L, et al. (2011) Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load. J Immunol 187: 2222-2232.
    • (2011) J Immunol , vol.187 , pp. 2222-2232
    • Day, C.L.1    Abrahams, D.A.2    Lerumo, L.3    Janse van Rensburg, E.4    Stone, L.5
  • 39
    • 79958073315 scopus 로고    scopus 로고
    • Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo
    • Bold TD, Banaei N, Wolf AJ, Ernst JD, (2011) Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo. PLoS Pathog 7 (5): e1002063.
    • (2011) PLoS Pathog , vol.7 , Issue.5
    • Bold, T.D.1    Banaei, N.2    Wolf, A.J.3    Ernst, J.D.4
  • 40
    • 33750319222 scopus 로고    scopus 로고
    • Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity
    • Dietrich J, Andersen C, Rappuoli R, Doherty TM, Jensen CG, et al. (2006) Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity. J Immunol 177: 6353-6360.
    • (2006) J Immunol , vol.177 , pp. 6353-6360
    • Dietrich, J.1    Andersen, C.2    Rappuoli, R.3    Doherty, T.M.4    Jensen, C.G.5
  • 41
    • 20144362100 scopus 로고    scopus 로고
    • Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6
    • Langermans JA, Doherty TM, Vervenne RA, van der Laan T, Lyashchenko K, et al. (2005) Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6. Vaccine 23: 2740-2750.
    • (2005) Vaccine , vol.23 , pp. 2740-2750
    • Langermans, J.A.1    Doherty, T.M.2    Vervenne, R.A.3    van der Laan, T.4    Lyashchenko, K.5
  • 42
    • 57349149604 scopus 로고    scopus 로고
    • Prognostic value of a T-cell-based, interferon-gamma biomarker in children with tuberculosis contact
    • Bakir M, Millington KA, Soysal A, Deeks JJ, Efee S, et al. (2008) Prognostic value of a T-cell-based, interferon-gamma biomarker in children with tuberculosis contact. Ann Intern Med 149: 777-787.
    • (2008) Ann Intern Med , vol.149 , pp. 777-787
    • Bakir, M.1    Millington, K.A.2    Soysal, A.3    Deeks, J.J.4    Efee, S.5
  • 43
    • 77956272068 scopus 로고    scopus 로고
    • Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal
    • Lienhardt C, Fielding K, Hane AA, Niang A, Ndao CT, et al. (2010) Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal. PLoS One 5: e10508.
    • (2010) PLoS One , vol.5
    • Lienhardt, C.1    Fielding, K.2    Hane, A.A.3    Niang, A.4    Ndao, C.T.5
  • 44
    • 73949150251 scopus 로고    scopus 로고
    • Non-clinical efficacy and safety of HyVac4:IC31 vaccine administered in a BCG prime-boost regimen
    • Skeiky YA, Dietrich J, Lasco TM, Stagliano K, Dheenadhayalan V, et al. (2010) Non-clinical efficacy and safety of HyVac4:IC31 vaccine administered in a BCG prime-boost regimen. Vaccine 28: 1084-1093.
    • (2010) Vaccine , vol.28 , pp. 1084-1093
    • Skeiky, Y.A.1    Dietrich, J.2    Lasco, T.M.3    Stagliano, K.4    Dheenadhayalan, V.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.