The mechanism of calcitonin gene-related peptide-containing nerve innervation

Journal of Pharmacological Sciences

Volumn 119, Issue 2, 2012, Pages 117-121

  Hashikawa Hobara, Narumi ^a   Hashikawa, Naoya ^a   Zamami, Yoshito ^b   Takatori, Shingo ^b   Kawasaki, Hiromu ^b  

^a OKAYAMA UNIVERSITY OF SCIENCE   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Angiotensin II type 2 receptor; Calcitonin gene related peptide containing nerve; Nerve growth factor mediated neurite outgrowth; PI3K Akt pathway

Indexed keywords

ADRENOMEDULLIN; ANGIOTENSIN 2 RECEPTOR; APOLIPOPROTEIN E; CALCITONIN GENE RELATED PEPTIDE; CANDESARTAN; CYCLIC GMP; FRUCTOSE; LOSARTAN; NERVE GROWTH FACTOR; NITROPRUSSIDE SODIUM; PHENOL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCATTER FACTOR;

ATHEROSCLEROSIS; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; HYPERTENSION; IMMUNOREACTIVITY; INNERVATION; INSULIN RESISTANCE; MESENTERIC ARTERY; MOUSE; NERVE ELONGATION; NERVE FIBER GROWTH; NERVE INJURY; NERVE INNERVATION; NERVE REGENERATION; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; REINNERVATION; REVIEW; SENSORY NERVE CELL; SPONTANEOUSLY HYPERTENSIVE RAT; VASODILATATION;

EID: 84863104279     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.12R02CP     Document Type: Review

References (28)

1. Kawasaki H, Takasaki K, Saito A, Goto K. Calcitonin gene-related peptide acts as a vasodilator neurotransmitter in mesenteric resistance vessels of the rat. Nature. 1988;335:164-167.
2. Kawasaki H, Nuki C, Saito A, Takasaki K. Role of calcitonin gene-related peptide containing nerves in the vascular adrenergic neurotransmission. J Pharmacol Exp Ther. 1990;252:403-409. (Pubitemid 20067743)
3. Kawasaki H, Nuki C, Saito A, Takasaki K. NPY modulates neurotransmission of CGRP-containing vasodilator nerves in rat mesenteric arteries. Am J Physiol. 1991;261:H683-H690.
4. Ishida-Yamamoto A, Tohyama M. Calcitonin gene-related peptide in the nervous system. Prog Neurobiol. 1989;33:335-386. (Pubitemid 20032990)
5. Marti E, Gibson SJ, Polak JM, Facer P, Springall DR, Van Aswegen G, et al. Ontogeny of peptide and amine-containing neurons in motor, sensory, and autonomic regions of rat and human spinal cord, dorsal root ganglia and rat skin. J Comp Neurol. 1987;266:332-359. (Pubitemid 18003969)
6. Hobara N, Gessei-Tsutsumi N, Goda M, Takayama F, Akiyama S, Kurosaki Y, et al. Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP)-containing nerves in spontaneously hypertensive rats. Hypertens Res. 2005;28:465-474. (Pubitemid 41007462)
7. Yang R, Powell-Braxton L, Ogaoawara AK, Dybdal N, Bunting S, Ohneda O, et al. Hypertension and endothelial dysfunction in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol. 1999;19:2762-2768. (Pubitemid 29536055)
8. Fullerton SM, Strittmatter WJ, Matthew WD. Peripheral sensory nerve defects in apolipoprotein E knockout mice. Exp Neurol. 1998;153:156-163. (Pubitemid 28452308)
9. Hashikawa-Hobara N, Hashikawa N, Yutani C, Zamami Y, Jin X, Takatori S, et al. The Akt-nitric oxide-cGMP pathway contributes to nerve growth factor-mediated neurite outgrowth in apolipo-protein E knockout mice. J Pharmacol Exp Ther. 2011;338: 694-700.
10. Takatori S, Zamami Y, Yabumae N, Hanafusa N, Mio M, Egawa T, et al. Pioglitazone opposes neurogenic vascular dysfunction associated with chronic hyperinsulinaemia. Br J Pharmacol. 2008;153:1388-1398. (Pubitemid 351481528)
11. Zamami Y, Takatori S, Hobara N, Yabumae N, Tangsucharit P, Jin X, et al. Hyperinsulinemia induces hypertension associated with neurogenic vascular dysfunction resulting from abnormal perivascular innervations in rat mesenteric resistance arteries. Hypertens Res. 2011;34:1190-1196.
12. 2+-induced relaxation of isolated arteries. Life Sci. 1999;64:887-894.
13. Hobara N, Goda M, Kitamura Y, Takayama F, Kawasaki H. Innervation and functional changes in mesenteric perivascular calcitonin gene-related peptide- and neuropeptide Y-containing nerves following topical phenol treatment. Neuroscience. 2006;141:1087-1099. (Pubitemid 44066641)
14. Hobara N, Nakamura A, Ohtsuka A, Narasaki M, Shibata K, Gomoita Y, et al. Distribution of adrenomedullin-containing perivascular nerves in the rat mesenteric artery. Peptides. 2004;25:589-599. (Pubitemid 38681058)
15. Hobara N, Goda M, Kitamura Y, Sendou T, Gomita Y, Kawasaki H. Adrenomedullin facilitates reinnervation of phenol-injured perivascular nerves in the rat mesenteric resistance artery. Neuroscience. 2007;144:721-730. (Pubitemid 44855300)
16. Honda S, Kagoshima M, Wanaka A, Tohyama M, Matsumoto K, Nakamura T. Localization and functional coupling of HGF and c-Met/HGF receptor in rat brain: implication as neurotrophic factor. Brain Res Mol Brain Res. 1995;32:197-210.
17. Ebens A, Brose K, Leonardo ED, Hanson MG Jr, Bladt F, Birchmeier C, et al. Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons. Neuron. 1996;17:1157-1172. (Pubitemid 27021101)
18. Hashimoto N, Yamanaka H, Fukuoka T, Dai Y, Obata K, Mashimo T, et al. Expression of HGF and cMet in the peripheral nervous system of adult rats following sciatic nerve injury. Neuroreport. 2001;12:1403-1407. (Pubitemid 32476137)
19. Okura Y, Arimoto H, Tanuma N, Matsumoto K, Nakamura T, Yamashima T, et al. Analysis of neurotrophic effects of hepatocyte growth factor in the adult hypoglossal nerve axotomy model. Eur J Neurosci. 1999;11:4139-4144. (Pubitemid 29537593)
20. Hobara N, Yoshida N, Goda M, Yokomizo A, Kitamura Y, Sendou T, et al. Neurotrophic effect of hepatic growth factor (HGF) on reinnervation of perivascular calcitonin gene-related peptide (CGRP)-containing nerves following phenol-induced nerve injury in the rat mesenteric artery. J Pharmacol Sci. 2008;108: 495-504.
21. Meffert S, Stoll M, Steckelings UM, Bottari SP, Unger T. The angiotensin AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells. Mol Cell Endocrinol. 1996; 122:59-67. (Pubitemid 26328859)
22. Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000;52:415-472.
23. Viswanathan M, Saavedra JM. Expression of angiotensin AT2 receptors in the rat skin during wound healing. Peptides. 1992; 13:783-786.
24. Gallinat S, Yu M, Dorst A, Unger T, Herdegen T. Sciatic nerve transection evokes lasting up-regulation of angiotensin AT2 and AT1 receptor mRNA in adult rat dorsal root ganglia and sciatic nerves. Brain Res Mol Brain Res. 1998;57:111-122. (Pubitemid 28279567)
25. Lucius R, Gallinat S, Rosenstiel P, Herdegen T, Sievers J, Unger T. The angiotensin II type 2 (AT2) receptor promotes axonal regeneration in the optic nerve of adult rats. J Exp Med. 1998; 188:661-670. (Pubitemid 28387929)
26. Hobara N, Goda M, Yoshida N, Takatori S, Kitamura Y, Mio M, et al. Angiotensin II type 2 receptors facilitate reinnervation of phenol-lesioned vascular calcitonin gene-related peptide-containing nerves in rat mesenteric arteries. Neuroscience. 2007; 150:730-741. (Pubitemid 350198723)
27. Hashikawa-Hobara N, Hashikawa N, Inoue Y, Sanda H, Zamami Y, Takatori S, et al. Candesartan cilexetil improves angiotensin II type 2 receptor-mediated neurite outgrowth via the PI3K-Akt pathway in fructose-induced insulin resistant rats. Diabetes. 2012;61:925-932.
28. Zawalich WS, Zawalich KC. A link between insulin resistance and hyperinsulinemia: inhibitors of phosphatidylinositol 3-kinase augment glucose-induced insulin secretion from islets of lean, but not obese, rats. Endocrinology. 2000;141:3287-3295. (Pubitemid 32269017)