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Volumn 13, Issue 10, 2012, Pages 1411-1420

The use of cephalosporins for gonorrhea: An update on the rising problem of resistance

Author keywords

Cephalosporin resistance; Neisseria gonorrhoeae

Indexed keywords

AZITHROMYCIN; CEFIXIME; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; DOXYCYCLINE; ERTAPENEM; EXTENDED SPECTRUM CEPHALOSPORIN DERIVATIVE; GEMIFLOXACIN; GENTAMICIN; SOLITHROMYCIN; SPECTINOMYCIN; UNCLASSIFIED DRUG;

EID: 84863085766     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2012.690396     Document Type: Review
Times cited : (18)

References (81)
  • 1
    • 65649083059 scopus 로고    scopus 로고
    • The use of cephalosporins for gonorrhea: The impending problem of resistance
    • Barry PM, Klausner JD. the use of cephalosporins for gonorrhea: The impending problem of resistance. Expert Opin Pharmacother 2009;10:555-77
    • (2009) Expert Opin. Pharmacother , vol.10 , pp. 555-77
    • Barry, P.M.1    Klausner, J.D.2
  • 2
    • 84857146496 scopus 로고    scopus 로고
    • High-level cefixime- and ceftriaxone-resistant N. gonorrhoeae in Europe (France): Novel penA mosaic allele in a successful international clone causes treatment failure
    • published online 12 December 2011 doi:10.1128/AAC.05760-11
    • Unemo M, Golparian D, Nicholas R, et al. High-level cefixime- and ceftriaxone-resistant N. gonorrhoeae in Europe (France): novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob Agents Chemother 2011;published online 12 December 2011; doi:10.1128/AAC.05760- 11
    • (2011) Antimicrob. Agents Chemother.
    • Unemo, M.1    Golparian, D.2    Nicholas, R.3
  • 3
    • 79959189164 scopus 로고    scopus 로고
    • Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea? detailed characterization of the first strain with high-level resistance to ceftriaxone
    • Ohnishi M, Golparian D, Shimuta K, et al. Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: Detailed characterization of the first strain with high-level resistance to ceftriaxone. Antimicrob Agents Chemother 2011;55:3538-45
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 3538-45
    • Ohnishi, M.1    Golparian, D.2    Shimuta, K.3
  • 4
    • 84857737837 scopus 로고    scopus 로고
    • Antibiotic resistance in Neisseria gonorrhoeae: Origin, evolution, and lessons learned for the future
    • Unemo M, Shafer WM. Antibiotic resistance in Neisseria gonorrhoeae: origin, evolution, and lessons learned for the future. Ann NY Acad Sci 2011;1230:E19-28
    • (2011) Ann. NY Acad. Sci. , vol.1230
    • Unemo, M.1    Shafer, W.M.2
  • 5
    • 80052962104 scopus 로고    scopus 로고
    • Sustainable antimicrobial surveillance programs essential for controlling Neisseria gonorrhoeae superbug
    • Dillon JA. Sustainable antimicrobial surveillance programs essential for controlling Neisseria gonorrhoeae superbug. Sex Transm Dis 2011;38:899-901
    • (2011) Sex Transm. Dis. , vol.38 , pp. 899-901
    • Dillon, J.A.1
  • 7
    • 70350627375 scopus 로고    scopus 로고
    • Meeting the public health challenge of multidrug- and extensively drug-resistant Neisseria gonorrhoeae
    • Tapsall JW, Ndowa F, Lewis DA, Unemo M. Meeting the public health challenge of multidrug- and extensively drug-resistant Neisseria gonorrhoeae. Expert Rev Anti Infect Ther 2009;7:821-34
    • (2009) Expert Rev. Anti. Infect. Ther. , vol.7 , pp. 821-34
    • Tapsall, J.W.1    Ndowa, F.2    Lewis, D.A.3    Unemo, M.4
  • 8
    • 82355191401 scopus 로고    scopus 로고
    • Prevalence and incidence of selected sexually transmitted infections: Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis and trichomonas vaginalis
    • World Health Organization Department of Reproductive Health and Research. Available from [Last accessed 19 December 2011]
    • World Health Organization Department of Reproductive Health and Research. Prevalence and incidence of selected sexually transmitted infections: Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis and Trichomonas vaginalis. Methods and results used by WHO to generate 2005 estimates. 2011. Available from: http://www.who.int/reproductivehealth/publications/rtis/9789241502450/en/index. html [Last accessed 19 December 2011]
    • (2011) Methods and Results Used by WHO to Generate 2005 Estimates
  • 10
    • 0033017798 scopus 로고    scopus 로고
    • From epidemiological synergy to public health policy and practice: The contribution of other sexually transmitted diseases to sexual transmission of HIV infection
    • Fleming DT, Wasserheit JN. From epidemiological synergy to public health policy and practice: The contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex Transm Infect 1999;75:3-17
    • (1999) Sex. Transm. Infect. , vol.75 , pp. 3-17
    • Fleming, D.T.1    Wasserheit, J.N.2
  • 11
    • 0034790065 scopus 로고    scopus 로고
    • A systematic review of the epidemiologic interactions between classic sexually transmitted diseases and HIV: How much really is known
    • Rottingen JA, Cameron DW, Garnett GP. A systematic review of the epidemiologic interactions between classic sexually transmitted diseases and HIV: how much really is known? Sex Transm Dis 2001;28:579-97
    • (2001) Sex. Transm. Dis. , vol.28 , pp. 579-97
    • Rottingen, J.A.1    Cameron, D.W.2    Garnett, G.P.3
  • 12
    • 19944429215 scopus 로고    scopus 로고
    • Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan
    • Ito M, Deguchi T, Mizutani KS, et al. Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan. Antimicrob Agents Chemother 2005;49:137-43
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 137-43
    • Ito, M.1    Deguchi, T.2    Mizutani, K.S.3
  • 13
    • 77956565733 scopus 로고    scopus 로고
    • Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: Role of epistatic mutations
    • Tomberg J, Unemo M, Davies C, Nicholas RA. Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: Role of epistatic mutations. Biochemistry 2010;49:8062-70
    • (2010) Biochemistry , vol.49 , pp. 8062-70
    • Tomberg, J.1    Unemo, M.2    Davies, C.3    Nicholas, R.A.4
  • 14
    • 0028906903 scopus 로고
    • Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system
    • Hagman KE, Pan W, Spratt BG, et al. Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology 1995;141:611-22
    • (1995) Microbiology , vol.141 , pp. 611-22
    • Hagman, K.E.1    Pan, W.2    Spratt, B.G.3
  • 15
    • 39149112789 scopus 로고    scopus 로고
    • Regulation of the MtrC-MtrD-MtrE efflux-pump system modulates the in vivo fitness of Neisseria gonorrhoeae
    • Warner DM, Folster JP, Shafer WM, Jerse AE. Regulation of the MtrC-MtrD-MtrE efflux-pump system modulates the in vivo fitness of Neisseria gonorrhoeae. J Infect Dis 2007;196:1804-12
    • (2007) J. Infect. Dis. , vol.196 , pp. 1804-12
    • Warner, D.M.1    Folster, J.P.2    Shafer, W.M.3    Jerse, A.E.4
  • 16
    • 34250186426 scopus 로고    scopus 로고
    • Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: Association with genetic polymorphisms in penA, mtrR, porB1b, and ponA
    • Lindberg R, Fredlund H, Nicholas R, Unemo M. Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: Association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. Antimicrob Agents Chemother 2007;51:2117-22
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 2117-22
    • Lindberg, R.1    Fredlund, H.2    Nicholas, R.3    Unemo, M.4
  • 17
    • 0031753295 scopus 로고    scopus 로고
    • Gonococcal resistance to beta-lactams and tetracycline involves mutation in loop 3 of the porin encoded at the penB locus
    • Gill MJ, Simjee S, Al-Hattawi K, et al. Gonococcal resistance to beta-lactams and tetracycline involves mutation in loop 3 of the porin encoded at the penB locus. Antimicrob Agents Chemother 1998;42:2799-803
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 2799-803
    • Gill, M.J.1    Simjee, S.2    Al-Hattawi, K.3
  • 18
    • 78449239981 scopus 로고    scopus 로고
    • Emergence, spread and characteristics of Neisseria gonorrhoeae isolates with in vitro decreased susceptibility and resistance to extended-spectrum cephalosporins in Sweden
    • Golparian D, Hellmark B, Fredlund H, Unemo M. Emergence, spread and characteristics of Neisseria gonorrhoeae isolates with in vitro decreased susceptibility and resistance to extended-spectrum cephalosporins in Sweden. Sex Transm Infect 2010;86:454-60
    • (2010) Sex. Transm. Infect. , vol.86 , pp. 454-60
    • Golparian, D.1    Hellmark, B.2    Fredlund, H.3    Unemo, M.4
  • 19
    • 70349135516 scopus 로고    scopus 로고
    • Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in neisseria gonorrhoeae
    • Zhao S, Duncan M, Tomberg J, et al. Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in neisseria gonorrhoeae. Antimicrob Agents Chemother 2009;53:3744-51
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 3744-51
    • Zhao, S.1    Duncan, M.2    Tomberg, J.3
  • 20
    • 65749101194 scopus 로고    scopus 로고
    • Phenotypic and genetic characterization of the WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance surveillance for public health purposes
    • Unemo M, Fasth O, Fredlund H, et al. Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance surveillance for public health purposes. J Antimicrob Chemother 2009;63:1142-51
    • (2008) J. Antimicrob. Chemother , vol.2009 , Issue.63 , pp. 1142-51
    • Unemo, M.1    Fasth, O.2    Fredlund, H.3
  • 21
    • 84862318667 scopus 로고    scopus 로고
    • Australian gonococcal surveillance programme annual report, 2010
    • Australian Gonococcal Surveillance Programme
    • Australian Gonococcal Surveillance Programme. Australian gonococcal surveillance programme annual report, 2010. Commun Dis Intell 2011;35:229-36
    • (2011) Commun. Dis. Intell. , vol.35 , pp. 229-36
  • 23
    • 33747882300 scopus 로고    scopus 로고
    • European surveillance of sexually transmitted infections (ESSTI): The first combined antimicrobial susceptibility data for Neisseria gonorrhoeae in Western Europe
    • Martin IM, Hoffmann S, Ison CA. European Surveillance of Sexually Transmitted Infections (ESSTI): The first combined antimicrobial susceptibility data for Neisseria gonorrhoeae in Western Europe. J Antimicrob Chemother 2006;58:587-93
    • (2006) J. Antimicrob. Chemother. , vol.58 , pp. 587-93
    • Martin, I.M.1    Hoffmann, S.2    Ison, C.A.3
  • 25
    • 34548420627 scopus 로고    scopus 로고
    • Threat to cefixime treatment for gonorrhea
    • Yokoi S, Deguchi T, Ozawa T, et al. Threat to cefixime treatment for gonorrhea. Emerg Infect Dis 2007;13:1275-7
    • (2007) Emerg. Infect. Dis. , vol.13 , pp. 1275-7
    • Yokoi, S.1    Deguchi, T.2    Ozawa, T.3
  • 26
    • 0037368377 scopus 로고    scopus 로고
    • Treatment of uncomplicated gonococcal urethritis by double-dosing of 200 mg cefixime at a 6-h interval
    • Deguchi T, Yasuda M, Yokoi S, et al. Treatment of uncomplicated gonococcal urethritis by double-dosing of 200 mg cefixime at a 6-h interval. J Infect Chemother 2003;9:35-9
    • (2003) J. Infect. Chemother. , vol.9 , pp. 35-9
    • Deguchi, T.1    Yasuda, M.2    Yokoi, S.3
  • 27
    • 54149119584 scopus 로고    scopus 로고
    • Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection
    • Lo JY, Ho KM, Leung AO, et al. Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. Antimicrob Agents Chemother 2008;52:3564-7
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 3564-7
    • Lo, J.Y.1    Ho, K.M.2    Leung, A.O.3
  • 28
    • 79957751469 scopus 로고    scopus 로고
    • Cefixime-resistant Neisseria gonorrhoeae in the UK: A time to reflect on practice and recommendations
    • Forsyth S, Penney P, Rooney G. Cefixime-resistant Neisseria gonorrhoeae in the UK: A time to reflect on practice and recommendations. Int J STD AIDS 2011;22:296-7
    • (2011) Int. J. STD AIDS , vol.22 , pp. 296-7
    • Forsyth, S.1    Penney, P.2    Rooney, G.3
  • 29
    • 79955441458 scopus 로고    scopus 로고
    • Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010
    • 16(14):pii=19833. Available from [Last accessed 11 May 2012]
    • Ison CA, Hussey J, Sankar KN, et al. Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010. Euro Surveill 2011;16(14):pii=19833. Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId= 19833 [Last accessed 11 May 2012]
    • (2011) Euro. Surveill
    • Ison, C.A.1    Hussey, J.2    Sankar, K.N.3
  • 30
    • 80455144975 scopus 로고    scopus 로고
    • First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011
    • 16(43):pii=19998. Available from [Last accessed 11 May 2012]
    • Unemo M, Golparian D, Stary A, Eigentler A. First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011. Euro Surveill 2011;16(43):pii=19998. Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19998 [Last accessed 11 May 2012]
    • (2011) Euro. Surveill
    • Unemo, M.1    Golparian, D.2    Stary, A.3    Eigentler, A.4
  • 31
    • 78649801372 scopus 로고    scopus 로고
    • Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment Norway, 2010
    • 15(47):pii=19721. Available from [Last accessed 11 May 2012]
    • Unemo M, Golparian D, Syversen G, et al. Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010. Euro Surveill 2010;15(47):pii=19721. Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19721 [Last accessed 11 May 2012]
    • (2010) Euro. Surveill
    • Unemo, M.1    Golparian, D.2    Syversen, G.3
  • 32
    • 80053643276 scopus 로고    scopus 로고
    • Emergence of a Neisseria gonorrhoeae clone showing decreased susceptibility to cefixime in England and Wales
    • Chisholm SA, Alexander S, Desouza-Thomas L, et al. Emergence of a Neisseria gonorrhoeae clone showing decreased susceptibility to cefixime in England and Wales. J Antimicrob Chemother 2011;66:2509-12
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 2509-12
    • Chisholm, S.A.1    Alexander, S.2    Desouza-Thomas, L.3
  • 33
    • 67650488213 scopus 로고    scopus 로고
    • Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods
    • Tapsall J, Read P, Carmody C, et al. Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods. J Med Microbiol 2009;58:683-7
    • (2009) J. Med. Microbiol. , vol.58 , pp. 683-7
    • Tapsall, J.1    Read, P.2    Carmody, C.3
  • 34
    • 79951640425 scopus 로고    scopus 로고
    • Ceftriaxone treatment failure of pharyngeal gonorrhoea verified by international recommendations Sweden July 2010
    • 16(6):pii=19792. Available from Last accessed 11 May 2012]
    • Unemo M, Golparian D, Hestner A. Ceftriaxone treatment failure of pharyngeal gonorrhoea verified by international recommendations, Sweden, July 2010. Euro Surveill 2011;16(6):pii=19792. Available from: http://www. eurosurveillance.org/ViewArticle.aspx?ArticleId=19792 [Last accessed 11 May 2012]
    • (2011) Euro. Surveill
    • Unemo, M.1    Golparian, D.2    Hestner, A.3
  • 35
    • 72049121868 scopus 로고    scopus 로고
    • Pharyngeal gonorrhea: An important reservoir of infection
    • Weinstock H, Workowski KA. Pharyngeal gonorrhea: An important reservoir of infection? Clin Infect Dis 2009;49:1798-800
    • (2009) Clin. Infect. Dis , vol.49 , pp. 1798-800
    • Weinstock, H.1    Workowski, K.A.2
  • 36
    • 65549091904 scopus 로고    scopus 로고
    • Incidence and treatment outcomes of pharyngeal Neisseria gonorrhoeae and Chlamydia trachomatis infections in men who have sex with men: A 13-year retrospective cohort study
    • Ota KV, Fisman DN, Tamari IE, et al. Incidence and treatment outcomes of pharyngeal Neisseria gonorrhoeae and Chlamydia trachomatis infections in men who have sex with men: A 13-year retrospective cohort study. Clin Infect Dis 2009;48:1237-43
    • (2009) Clin. Infect. Dis. , vol.48 , pp. 1237-43
    • Ota, K.V.1    Fisman, D.N.2    Tamari, I.E.3
  • 37
    • 78650967538 scopus 로고    scopus 로고
    • Ceftriaxone-resistant Neisseria gonorrhoeae, Japan
    • Ohnishi M, Saika T, Hoshina S, et al. Ceftriaxone-resistant Neisseria gonorrhoeae, Japan. Emerg Infect Dis 2011;17:148-9
    • (2011) Emerg. Infect. Dis. , vol.17 , pp. 148-9
    • Ohnishi, M.1    Saika, T.2    Hoshina, S.3
  • 38
    • 70349144489 scopus 로고    scopus 로고
    • Mosaic penicillin-binding protein 2 in Neisseria gonorrhoeae isolates collected in 2008 in San Francisco, California
    • Pandori M, Barry PM, Wu A, et al. Mosaic penicillin-binding protein 2 in Neisseria gonorrhoeae isolates collected in 2008 in San Francisco, California. Antimicrob Agents Chemother 2009;53:4032-4
    • Antimicrob. Agents Chemother. , vol.2009 , Issue.53 , pp. 4032-4
    • Pandori, M.1    Barry, P.M.2    Wu, A.3
  • 39
    • 78049286767 scopus 로고    scopus 로고
    • Characteristics and dissemination of mosaic penicillin-binding protein 2-harboring multidrug-resistant Neisseria gonorrhoeae isolates with reduced cephalosporin susceptibility in northern Taiwan
    • Huang CT, Yen MY, Wong WW, et al. Characteristics and dissemination of mosaic penicillin-binding protein 2-harboring multidrug-resistant Neisseria gonorrhoeae isolates with reduced cephalosporin susceptibility in northern Taiwan. Antimicrob Agents Chemother 2010;54:4893-5
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 4893-5
    • Huang, C.T.1    Yen, M.Y.2    Wong, W.W.3
  • 40
    • 78751680159 scopus 로고    scopus 로고
    • Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada
    • Allen VG, Farrell DJ, Rebbapragada A, et al. Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. Antimicrob Agents Chemother 2011;55:703-12
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 703-12
    • Allen, V.G.1    Farrell, D.J.2    Rebbapragada, A.3
  • 41
    • 33750591337 scopus 로고    scopus 로고
    • Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseria gonorrhoeae
    • Takahata S, Senju N, Osaki Y, et al. Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseria gonorrhoeae. Antimicrob Agents Chemother 2006;50:3638-45
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 3638-45
    • Takahata, S.1    Senju, N.2    Osaki, Y.3
  • 42
    • 80051867096 scopus 로고    scopus 로고
    • Gonorrhoea surveillance, laboratory diagnosis and antimicrobial susceptibility testing of Neisseria gonorrhoeae in 11 countries of the eastern part of the WHO European region
    • Unemo M, Shipitsyna E, Domeika M. Gonorrhoea surveillance, laboratory diagnosis and antimicrobial susceptibility testing of Neisseria gonorrhoeae in 11 countries of the eastern part of the WHO European region. APMIS 2011;119:643-9
    • (2011) APMIS , vol.119 , pp. 643-9
    • Unemo, M.1    Shipitsyna, E.2    Domeika, M.3
  • 43
    • 0004111883 scopus 로고    scopus 로고
    • World Health Organization Department of Reproductive Health and Research Available from [Last accessed 19 December 2011]
    • World Health Organization Department of Reproductive Health and Research. Guidelines for the management of sexually transmitted infections. 2003. Available from: http://www.who.int/reproductivehealth/publications/rtis/ 9241546263/en/index.html [Last accessed 19 December 2011]
    • (2003) Guidelines for the Management of Sexually Transmitted Infections
  • 44
    • 27744483972 scopus 로고    scopus 로고
    • World Health Organization Department of Reproductive Health and Research Available from [Last accessed 19 December 2011]
    • World Health Organization Department of Reproductive Health and Research. Sexually transmitted and other reproductive tract infections: A guide to essential practice. 2005. Available from: http://www.who.int/reproductivehealth/ publications/rtis/9241592656/en/index. html [Last accessed 19 December 2011]
    • (2005) Sexually Transmitted and Other Reproductive Tract Infections: A Guide to Essential Practice
  • 45
    • 67651251366 scopus 로고    scopus 로고
    • Global strategy for the prevention and control of sexually transmitted infections 2006-2015
    • World Health Organization Department of Reproductive Health and Research Available from [Last accessed 19 December 2011]
    • World Health Organization Department of Reproductive Health and Research. Global strategy for the prevention and control of sexually transmitted infections: 2006 - 2015. Breaking the chain of transmission. 2007. Available from: http://www.who.int/reproductivehealth/publications/rtis/9789241563475/en/ index.html [Last accessed 19 December 2011]
    • (2007) Breaking the Chain of Transmission
  • 46
    • 68249126403 scopus 로고    scopus 로고
    • Implications of current recommendations for third-generation cephalosporin use in the WHO western pacific region following the emergence of multiresistant gonococci
    • Tapsall JW. Implications of current recommendations for third-generation cephalosporin use in the WHO western pacific region following the emergence of multiresistant gonococci. Sex Transm Infect 2009;85:256-8
    • (2009) Sex. Transm. Infect. , vol.85 , pp. 256-8
    • Tapsall, J.W.1
  • 47
    • 78449242759 scopus 로고    scopus 로고
    • Recommended antimicrobial treatment of uncomplicated gonorrhoea in 2009 in 11 East European countries: Implementation of a Neisseria gonorrhoeae antimicrobial susceptibility programme in this region is crucial
    • Unemo M, Shipitsyna E, Domeika M. Recommended antimicrobial treatment of uncomplicated gonorrhoea in 2009 in 11 East European countries: Implementation of a Neisseria gonorrhoeae antimicrobial susceptibility programme in this region is crucial. Sex Transm Infect 2010;86:442-4
    • Sex. Transm. Infect. , vol.2010 , Issue.86 , pp. 442-4
    • Unemo, M.1    Shipitsyna, E.2    Domeika, M.3
  • 48
    • 67650120398 scopus 로고    scopus 로고
    • 2009 European (IUSTI/WHO) guideline on the diagnosis and treatment of gonorrhoea in adults
    • Bignell C. 2009 European (IUSTI/WHO) guideline on the diagnosis and treatment of gonorrhoea in adults. Int J STD AIDS 2009;20:453-7
    • (2009) Int. J. STD AIDS , vol.20 , pp. 453-7
    • Bignell, C.1
  • 49
    • 80054750360 scopus 로고    scopus 로고
    • UK national guideline for the management of gonorrhoea in adults, 2011
    • Bignell C, Fitzgerald M. UK national guideline for the management of gonorrhoea in adults, 2011. Int J STD AIDS 2011;22:541-7
    • (2011) Int. J. STD AIDS , vol.22 , pp. 541-7
    • Bignell, C.1    Fitzgerald, M.2
  • 50
    • 78650626559 scopus 로고    scopus 로고
    • Sexually transmitted diseases treatment guidelines, 2010
    • Workowski KA, Berman S. Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep 2010;59:1-110
    • (2010) MMWR Recomm. Rep. , vol.59 , pp. 1-110
    • Workowski, K.A.1    Berman, S.2
  • 51
    • 79960262635 scopus 로고    scopus 로고
    • Cephalosporin susceptibility among Neisseria gonorrhoeae isolates-United States, 2000-2010
    • Centers for Disease Control and Prevention.
    • Centers for Disease Control and Prevention. Cephalosporin susceptibility among Neisseria gonorrhoeae isolates - United States, 2000 - 2010. MMWR Morb Mortal Wkly Rep 2011;60:873-7
    • (2011) MMWR Morb. Mortal. Wkly Rep. , vol.60 , pp. 873-7
  • 52
    • 33750683395 scopus 로고    scopus 로고
    • Prevalence and incidence of pharyngeal gonorrhea in a longitudinal sample of men who have sex with men: The explore study
    • Morris SR, Klausner JD, Buchbinder SP, et al. Prevalence and incidence of pharyngeal gonorrhea in a longitudinal sample of men who have sex with men: The EXPLORE study. Clin Infect Dis 2006;43:1284-9
    • (2006) Clin. Infect. Dis. , vol.43 , pp. 1284-9
    • Morris, S.R.1    Klausner, J.D.2    Buchbinder, S.P.3
  • 53
    • 20844440736 scopus 로고    scopus 로고
    • Prevalence of rectal, urethral, and pharyngeal chlamydia and gonorrhea detected in 2 clinical settings among men who have sex with men: San Francisco, California, 2003
    • Kent CK, Chaw JK, Wong W, et al. Prevalence of rectal, urethral, and pharyngeal chlamydia and gonorrhea detected in 2 clinical settings among men who have sex with men: San Francisco, California, 2003. Clin Infect Dis 2005;41:67-74
    • (2005) Clin. Infect. Dis. , vol.41 , pp. 67-74
    • Kent, C.K.1    Chaw, J.K.2    Wong, W.3
  • 54
    • 53549095716 scopus 로고    scopus 로고
    • Sexually transmitted infections among brothel-based sex workers in tel-aviv area, israel: High prevalence of pharyngeal gonorrhoea
    • Linhart Y, Shohat T, Amitai Z, et al. Sexually transmitted infections among brothel-based sex workers in Tel-Aviv area, Israel: high prevalence of pharyngeal gonorrhoea. Int J STD AIDS 2008;19:656-9
    • (2008) Int. J. STD AIDS , vol.19 , pp. 656-9
    • Linhart, Y.1    Shohat, T.2    Amitai, Z.3
  • 55
    • 72049112548 scopus 로고    scopus 로고
    • Chlamydia trachomatis and Neisseria gonorrhoeae transmission from the oropharynx to the urethra among men who have sex with men
    • Bernstein KT, Stephens SC, Barry PM, et al. Chlamydia trachomatis and Neisseria gonorrhoeae transmission from the oropharynx to the urethra among men who have sex with men. Clin Infect Dis 2009;49:1793-7
    • (2009) Clin. Infect. Dis. , vol.49 , pp. 1793-7
    • Bernstein, K.T.1    Stephens, S.C.2    Barry, P.M.3
  • 56
    • 0036895278 scopus 로고    scopus 로고
    • Mosaic-like structure of penicillin-binding protein 2 Gene (penA) in clinical isolates of Neisseria gonorrhoeae with reduced susceptibility to cefixime
    • Ameyama S, Onodera S, Takahata M, et al. Mosaic-like structure of penicillin-binding protein 2 Gene (penA) in clinical isolates of Neisseria gonorrhoeae with reduced susceptibility to cefixime. Antimicrob Agents Chemother 2002;46:3744-9
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3744-9
    • Ameyama, S.1    Onodera, S.2    Takahata, M.3
  • 57
    • 0023947142 scopus 로고
    • Prevalence and persistence of Neisseria cinerea and other Neisseria spp in adults
    • Knapp JS, Hook EW III. Prevalence and persistence of Neisseria cinerea and other Neisseria spp. in adults. J Clin Microbiol 1988;26:896-900
    • (1988) J. Clin. Microbiol. , vol.26 , pp. 896-900
    • Knapp, J.S.1    Hook III, E.W.2
  • 58
    • 78449255075 scopus 로고    scopus 로고
    • Pharyngeal gonorrhoea: A silent cause for concern
    • Kinghorn G. Pharyngeal gonorrhoea: A silent cause for concern. Sex Transm Infect 2010;86:413-14
    • (2010) Sex. Transm. Infect. , vol.86 , pp. 413-14
    • Kinghorn, G.1
  • 59
    • 32944465964 scopus 로고    scopus 로고
    • Nucleic acid amplification testing for Neisseria gonorrhoeae: An ongoing challenge
    • Whiley DM, Tapsall JW, Sloots TP. Nucleic acid amplification testing for Neisseria gonorrhoeae: An ongoing challenge. J Mol Diagn 2006;8:3-15
    • (2006) J. Mol. Diagn. , vol.8 , pp. 3-15
    • Whiley, D.M.1    Tapsall, J.W.2    Sloots, T.P.3
  • 60
    • 84858626063 scopus 로고    scopus 로고
    • Enhanced gonococcal antimicrobial surveillance in the era of ceftriaxone resistance: A real-time PCR assay for direct detection of the Neisseria gonorrhoeae H041 strain
    • Goire N, Ohnishi M, Limnios AE, et al. Enhanced gonococcal antimicrobial surveillance in the era of ceftriaxone resistance: A real-time PCR assay for direct detection of the Neisseria gonorrhoeae H041 strain. J Antimicrob Chemother 2012;67:902-5
    • (2012) J. Antimicrob. Chemother. , Issue.67 , pp. 902-5
    • Goire, N.1    Ohnishi, M.2    Limnios, A.E.3
  • 61
    • 79960146321 scopus 로고    scopus 로고
    • Review and international recommendation of methods for typing neisseria gonorrhoeae isolates and their implications for improved knowledge of gonococcal epidemiology, treatment, and biology
    • Unemo M, Dillon JA. Review and international recommendation of methods for typing neisseria gonorrhoeae isolates and their implications for improved knowledge of gonococcal epidemiology, treatment, and biology. Clin Microbiol Rev 2011;24:447-58
    • (2011) Clin. Microbiol. Rev. , vol.24 , pp. 447-58
    • Unemo, M.1    Dillon, J.A.2
  • 62
    • 77957231790 scopus 로고    scopus 로고
    • Cephalosporin MIC creep among gonococci time for a pharmacodynamic rethink
    • Chisholm SA, Mouton JW, Lewis DA, et al. Cephalosporin MIC creep among gonococci: Time for a pharmacodynamic rethink? J Antimicrob Chemother 2010;65:2141-8
    • (2010) J. Antimicrob. Chemother. , vol.65 , pp. 2141-8
    • Chisholm, S.A.1    Mouton, J.W.2    Lewis, D.A.3
  • 63
    • 84855881092 scopus 로고    scopus 로고
    • Cephalosporin resistant Neisseria gonorrhoeae: Time to consider gentamicin
    • Ross JD, Lewis DA. Cephalosporin resistant Neisseria gonorrhoeae: Time to consider gentamicin? Sex Transm Infect 2012;88:6-8
    • (2012) Sex. Transm. Infect. , Issue.88 , pp. 6-8
    • Ross, J.D.1    Lewis, D.A.2
  • 65
    • 82555193753 scopus 로고    scopus 로고
    • Antimicrobial resistance in Neisseria gonorrhoeae and Treponema pallidum: Evolution, therapeutic challenges and the need to strengthen global surveillance
    • Lewis DA, Lukehart SA. Antimicrobial resistance in Neisseria gonorrhoeae and Treponema pallidum: evolution, therapeutic challenges and the need to strengthen global surveillance. Sex Transm Infect 2011;87(Suppl 2):39-43
    • (2011) Sex. Transm. Infect. , vol.87 , Issue.SUPPL. 2 , pp. 39-43
    • Lewis, D.A.1    Lukehart, S.A.2
  • 66
    • 51349130594 scopus 로고    scopus 로고
    • Single dose 1 g ceftriaxone for urogenital and pharyngeal infection caused by Neisseria gonorrhoeae
    • Muratani T, Inatomi H, Ando Y, et al. Single dose 1 g ceftriaxone for urogenital and pharyngeal infection caused by Neisseria gonorrhoeae. Int J Urol 2008;15:837-42
    • (2008) Int. J. Urol. , vol.15 , pp. 837-42
    • Muratani, T.1    Inatomi, H.2    Ando, Y.3
  • 67
    • 84863092867 scopus 로고    scopus 로고
    • Emergence of multidrug-resistant Neisseria gonorrhoeae strains circulating worldwide
    • Epub ahead of print]
    • Tanaka M. Emergence of multidrug-resistant Neisseria gonorrhoeae strains circulating worldwide. Int J Urol 2011. [Epub ahead of print]
    • (2011) Int. J. Urol.
    • Tanaka, M.1
  • 69
    • 0028940924 scopus 로고
    • Drugs of choice for the treatment of uncomplicated gonococcal infections
    • Moran JS, Levine WC. Drugs of choice for the treatment of uncomplicated gonococcal infections. Clin Infect Dis 1995;20(Suppl 1):47-65
    • (1995) Clin. Infect. Dis. , vol.20 , Issue.SUPPL. 1 , pp. 47-65
    • Moran, J.S.1    Levine, W.C.2
  • 70
    • 43049134177 scopus 로고    scopus 로고
    • Emerging antimicrobial resistance in Neisseria gonorrhoeae: Urgent need to strengthen prevention strategies
    • Workowski KA, Berman SM, Douglas JM Jr. Emerging antimicrobial resistance in Neisseria gonorrhoeae: urgent need to strengthen prevention strategies. Ann Intern Med 2008;148:606-13
    • (2008) Ann. Intern. Med. , vol.148 , pp. 606-13
    • Workowski, K.A.1    Berman, S.M.2    Douglas Jr., J.M.3
  • 71
    • 84857566084 scopus 로고    scopus 로고
    • Neisseria gonorrhoeae with high-level resistance to azithromycin: Case report of the first isolate identified in the United States
    • published online 19 Dec 2011 doi:10.1093/cid/cir929
    • Katz AR, Komeya AY, Soge OO, et al. Neisseria gonorrhoeae with high-level resistance to azithromycin: Case report of the first isolate identified in the United States. Clin Infect Dis 2011;published online 19 Dec 2011; doi:10.1093/cid/cir929
    • (2011) Clin. Infect. Dis.
    • Katz, A.R.1    Komeya, A.Y.2    Soge, O.O.3
  • 72
    • 84872206010 scopus 로고    scopus 로고
    • National Institute of Allergy and Infectious Diseases (NIAID) Available from [Last accessed 2 February 2012]
    • National Institute of Allergy and Infectious Diseases (NIAID). Efficacy of Combination Therapies for Gonorrhea Treatment. ClinicalTrialsgov, 2010. Available from: http://clinicaltrials. gov/ct2/show/NCT00926796 NLM Identifier: NCT00926796 [Last accessed 2 February 2012]
    • (2010) Efficacy of Combination Therapies for Gonorrhea Treatment. Clinical Trialsgov
  • 74
    • 79951520585 scopus 로고    scopus 로고
    • An evaluation of gentamicin susceptibility of Neisseria gonorrhoeae isolates in Europe
    • Chisholm SA, Quaye N, Cole MJ, et al. An evaluation of gentamicin susceptibility of Neisseria gonorrhoeae isolates in Europe. J Antimicrob Chemother 2011; 66:592-5
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 592-5
    • Chisholm, S.A.1    Quaye, N.2    Cole, M.J.3
  • 75
    • 77953240856 scopus 로고    scopus 로고
    • Spectinomycin in the treatment of gonorrhoea
    • 15(19):pii/19568-author reply pii/69
    • Gil-Setas A, Navascues-Ortega A, Beristain X. Spectinomycin in the treatment of gonorrhoea. Euro Surveill 2010;15(19):pii/19568-author reply pii/69
    • (2010) Euro. Surveill
    • Gil-Setas, A.1    Navascues-Ortega, A.2    Beristain, X.3
  • 76
    • 84860176932 scopus 로고    scopus 로고
    • In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: Potential treatment option for gonorrhea
    • Golparian D, Fernandes P, Ohnishi M, et al. in vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatment option for gonorrhea? Antimicrob Agents Chemother 2012;56:2739-42
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 2739-42
    • Golparian, D.1    Fernandes, P.2    Ohnishi, M.3
  • 77
    • 79955951019 scopus 로고    scopus 로고
    • Cefpodoxime 10 mcg disc screening test for detection of Neisseria gonorrhoeae with mosaic PBP2 and decreased susceptibility to extended-spectrum cephalosporins for public health purposes
    • Limnios A, Tapsall J, Kahlmeter J, et al. Cefpodoxime 10 mcg disc screening test for detection of Neisseria gonorrhoeae with mosaic PBP2 and decreased susceptibility to extended-spectrum cephalosporins for public health purposes. APMIS 2011;119:356-63
    • (2011) APMIS , vol.119 , pp. 356-63
    • Limnios, A.1    Tapsall, J.2    Kahlmeter, J.3
  • 78
    • 84857328447 scopus 로고    scopus 로고
    • Changes in fluoroquinolone use for gonorrhea following publication of revised treatment guidelines
    • published online 28 Nov 2011 doi:10.2105/AJPH.2011.300283
    • Dowell D, Tian LH, Stover JA, et al. Changes in fluoroquinolone use for gonorrhea following publication of revised treatment guidelines. Am J Public Health 2011;published online 28 Nov 2011; doi:10.2105/AJPH.2011.300283
    • (2011) Am. J. Public Health
    • Dowell, D.1    Tian, L.H.2    Stover, J.A.3
  • 79
    • 79960729480 scopus 로고    scopus 로고
    • Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO western pacific and south east asian regions, 2009
    • WHO Western Pacific and South East Asian Gonococcal Antimicrobial Surveillance Programmes
    • WHO Western Pacific and South East Asian Gonococcal Antimicrobial Surveillance Programmes. Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian Regions, 2009. Commun Dis Intell 2011;35:2-7
    • (2011) Commun. Dis. Intell. , vol.35 , pp. 2-7
  • 80
    • 77951043519 scopus 로고    scopus 로고
    • The Russian gonococcal antimicrobial susceptibility programme (RU-GASP)-national resistance prevalence in 2007 and 2008, and trends during 2005-2008
    • 15(14):pii=19533. Available from [Last accessed 11 May 2012]
    • Kubanova A, Frigo N, Kubanov A, et al. the Russian gonococcal antimicrobial susceptibility programme (RU-GASP) - national resistance prevalence in 2007 and 2008, and trends during 2005 - 2008. Euro Surveill 2010;15(14):pii=19533. Available from: http://www.eurosurveillance.org/ ViewArticle.aspx?ArticleId=19533 [Last accessed 11 May 2012]
    • (2010) Euro. Surveill
    • Kubanova, A.1    Frigo, N.2    Kubanov, A.3
  • 81
    • 80054829542 scopus 로고    scopus 로고
    • The European gonococcal antimicrobial surveillance programme, 2009
    • 16(42):pii=19995. Available from [Last accessed 11 May 2012]
    • Cole MJ, Unemo M, Hoffmann S, et al. the European gonococcal antimicrobial surveillance programme, 2009. Euro Surveill 2011;16(42):pii=19995. Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId= 19995 [Last accessed 11 May 2012]
    • (2011) Euro. Surveill
    • Cole, M.J.1    Unemo, M.2    Hoffmann, S.3


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