Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment

Journal of Cell Science

Volumn 125, Issue 7, 2012, Pages 1652-1656

  Singh, Rajesh K ^a   Liao, Wenjia ^a   Tracey White, Dhani ^a   Recchi, Chiara ^a   Tolmachova, Tanya ^a   Rankin, Sara M ^a   Hume, Alistair N ^a,d   Seabra, Miguel C ^a,b,c  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b NOVA MEDICAL SCHOOL   (Portugal)

^c INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^d QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Cell migration; Chemotaxis; Neutrophil; Rab27a; Uropod

Indexed keywords

CD11B ANTIGEN; ELASTASE; GUANOSINE TRIPHOSPHATASE; RAB27A GTPASE; RAB27A PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL STRUCTURES; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; ENZYME RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE MIGRATION; MICROSCOPY; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL MIGRATION; NONHUMAN; PRIORITY JOURNAL; UROPOD;

ANIMALS; CELL MOVEMENT; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NEUTROPHILS; RAB GTP-BINDING PROTEINS;

UROPODA;

EID: 84863083748     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.100438     Document Type: Article

References (20)

1. Alblas, J., Ulfman, L., Hordijk, P. and Koenderman, L. (2001). Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes. Mol. Biol. Cell 12, 2137-2145.
2. Barral, D.C., Ramalho, J. S., Anders, R., Hume, A. N., Knapton, H. J., Tolmachova, T., Collinson, L. M., Goulding, D., Authi, K. S. and Seabra, M. C. (2002). Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J. Clin. Invest. 110, 247-257.
3. Benson, K. F., Li, F. Q., Person, R. E., Albani, D., Duan, Z., Wechsler, J., Meade-White, K., Williams, K., Acland, G. M., Niemeyer, G. et al. (2003). Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase. Nat. Genet. 35, 90-96.
4. Brzezinska, A. A., Johnson, J. L., Munafo, D. B., Crozat, K., Beutler, B., Kiosses, W. B., Ellis, B. A. and Catz, S. D. (2008). The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules. Traffic 9, 2151-2164.
5. Chatterjee, B. E., Yona, S., Rosignoli, G., Young, R. E., Nourshargh, S., Flower, R. J. and Perretti, M. (2005). Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J. Leukoc. Biol. 78, 639-646.
6. Colvin, R. A., Means, T. K., Diefenbach, T. J., Moita, L. F., Friday, R. P., Sever, S., Campanella, G. S., Abrazinski, T., Manice, L. A., Moita, C. et al. (2010). Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat. Immunol. 11, 495-502.
7. Fukuda, M. (2008). Regulation of secretory vesicle traffic by Rab small GTPases. Cell. Mol. Life Sci. 65, 2801-2813.
8. Fulton, S. A., Reba, S. M., Martin, T. D. and Boom, W. H. (2002). Neutrophilmediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice. Infect. Immun. 70, 5322-5327.
9. Hendrix, A., Maynard, D., Pauwels, P., Braems, G., Denys, H., Van den Broecke, R., Lambert, J., Van Belle, S., Cocquyt, V., Gespach, C. et al. (2010). Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. J. Natl. Cancer Inst. 102, 866-880.
10. Izumi, T. (2007). Physiological roles of Rab27 effectors in regulated exocytosis. Endocr. J. 54, 649-657.
11. Kessenbrock, K., Frohlich, L., Sixt, M., Lammermann, T., Pfister, H., Bateman, A., Belaaouaj, A., Ring, J., Ollert, M., Fassler, R. et al. (2008). Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J. Clin. Invest. 118, 2438-2447.
12. Kurugöl, Z., Ozkinay, F., Vardar, F., Karacali, S., Kutukculer, N., Deveci, R. and Ozkinay, C. (2001). Griscelli syndrome: report of a case and review of the literature. Pediatr. Int. 43, 298-301.
13. Lee, W. L. and Downey, G. P. (2001). Leukocyte elastase: physiological functions and role in acute lung injury. Am. J. Respir. Crit. Care Med. 164, 896-904.
14. Munafó, D. B., Johnson, J. L., Ellis, B. A., Rutschmann, S., Beutler, B. and Catz, S. D. (2007). Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. Biochem. J. 402, 229-239.
15. Nathan, C. (2006). Neutrophils and immunity: challenges and opportunities. Nat. Rev. Immunol. 6, 173-182.
16. Pham, C. T. (2006). Neutrophil serine proteases: specific regulators of inflammation. Nat. Rev. Immunol. 6, 541-550.
17. Tolmachova, T., Anders, R., Stinchcombe, J., Bossi, G., Griffiths, G. M., Huxley, C. and Seabra, M. C. (2004). A general role for Rab27a in secretory cells. Mol. Biol. Cell 15, 332-344.
18. Weller, C. L., Collington, S. J., Brown, J. K., Miller, H. R., Al-Kashi, A., Clark, P., Jose, P. J., Hartnell, A. and Williams, T. J. (2005). Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors. J. Exp. Med. 201, 1961-1971.
19. Wengner, A. M., Pitchford, S. C., Furze, R. C. and Rankin, S. M. (2008). The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation. Blood 111, 42-49.
20. Zen, K., Guo, Y. L., Li, L. M., Bian, Z., Zhang, C. Y. and Liu, Y. (2011). Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis. Blood 117, 4885-4894.