Glomerulotubular junction abnormalities are associated with proteinuria in type 1 diabetes

Journal of the American Society of Nephrology

Volumn 17, Issue SUPPL. 2, 2006, Pages

  Najafian, Behzad ^a   Crosson, John T ^a   Kim, Youngki ^a   Mauer, Michael ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b MMC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN;

ADHESION; ADOLESCENT; ADULT; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ELECTRON MICROSCOPY; FEMALE; GLOMERULUS; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN TISSUE; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY BIOPSY; KIDNEY TUBULE; MALE; MICROALBUMINURIA; MICROSCOPY; PRIORITY JOURNAL; PROTEINURIA; STEREOMETRY;

EID: 33645471589     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2005121342     Document Type: Conference Paper

References (31)

1. United States Renal Data System (USRDS): 2003 Annual Data Report, Bethesda, National Institutes of Health, 2003
2. Hovind P, Tarnow L, Rossing P, Jensen BR, Graae M, Torp I, Binder C, Parving HH: Predictors for the development of microalbuminuria and macroalbuminuria in patients with type 1 diabetes: Inception cohort study. BMJ 328: 1105-1108, 2004
3. Caramori ML, Kim Y, Huang C, Fish AJ, Rich SS, Miller ME, Russell G, Mauer M: Cellular basis of diabetic nephropathy: 1. Study design and renal structural-functional relationships in patients with longstanding type 1 diabetes. Diabetes 51: 506-513, 2002
4. Najafian B, Kim Y, Crosson JT, Mauer M: Atubular glomeruli and glomerulotubular junction abnormalities in diabetic nephropathy. J Am Soc Nephrol 14: 908-917, 2003
5. Howie AJ, Brewer DB: Further studies on the glomerular tip lesion: Early and late stages and life table analysis. J Pathol 147: 245-255, 1985
6. Huppes W, Hene RJ, Kooiker CJ: The glomerular tip lesion: A distinct entity or not? J Pathol 154: 187-190, 1988
7. Howie AJ: Changes at the glomerular tip: A feature of membranous nephropathy and other disorders associated with proteinuria. J Pathol 150: 13-20, 1986
8. Chavers BM, Simonson J, Michael AF: A solid phase fluorescent immunoassay for the measurement of human urinary albumin. Kidney Int 25: 576-578, 1984
9. Gaspari F, Perico N, Remuzzi G: Measurement of glomerular filtration rate. Kidney Int Suppl 63: S151-S154, 1997
10. Elus EN, Wiegmann TB, Savin VJ: Diminished glomerular capillary hydraulic conductivity precedes morphologic changes in experimental diabetes mellitus in rats. Diabetes 41: 1106-1112, 1992
11. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ; National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee: The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. JAMA 289: 2560-2572, 2003
12. Sterio DC: The unbiased estimation of the number and sizes of arbitrary particles using the disector. J Microsc 134: 127-136, 1984
13. Gundersen HJ, Jensen EB: The efficiency of systematic sampling in stereology and its prediction. J Microsc 147: 229-263, 1987
14. Mauer SM, Steffes MW, Ellis EN, Sutherland DE, Brown DM, Goetz FC: Structural-functional relationships in diabetic nephropathy. J Clin Invest 74: 1143-1155, 1984
15. Fioretto P, Steffes MW, Mauer M: Glomerular structure in non-proteinuric IDDM patients with various levels of albuminuria. Diabetes 43: 1358-1364, 1994
16. Gundersen HJG, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorensen FB, Vesterby A, West MJ: Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96: 379-394, 1988
17. Gundersen HJ, Jensen TB, Osterby R: Distribution of membrane thickness determined by lineal analysis. J Microsc 113: 27-43, 1978
18. Howie AJ, Pankhurst T, Sarioglu S, Turhan N, Adu D: Evolution of nephritic associated focal segmental glomerulosclerosis and relation to the glomerular tip lesion. Kidney Int 67: 987-1001, 2005
19. O'Donnell MP, Kasiske BL, Keane WF: Glomerular hemodynamic and structural alterations in experimental diabetes. FASEB J 2: 2339-2347, 1988
20. Zatz R, Meyer TM, Rennke HG, Brenner BM: Predominance of hemodynamic rather than metabolic factors in the pathogenesis of diabetic glomerulopathy. Proc Natl Acad Sci USA 82: 5963-5967, 1985
21. Perkins BA, Ficociello LH, Silva KH, Finkelstein DM, Warram JH, Krolewski AS: Regression of microalbuminuria in type 1 diabetes. N Engl J Med 348: 2285-2293, 2003
22. Giorgino F, Laviola L, Cavallo Perin P, Solnica B, Fuller J, Chaturvedi N: Factors associated with progression to macroalbuminuria in microalbuminuric type 1 diabetic patients: The EURODIAB Prospective Complications Study. Diabetologia 47: 1020-1028, 2004
23. Delia Vestra M, Masiero A, Roiter AM, Sailer A, Crepaldi G, Fioretto P: Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes. Diabetes 52: 1031-1035, 2003
24. White KE, Bilous RW, Marshall SM, El Nahas M, Remuzzi G, Piras G, De Cosmo S, Viberti G: Podocyte number in normotensive type 1 diabetic patients with albuminuria. Diabetes 51: 3083-3089, 2002
25. Eddy AA: Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions. J Am Soc Nephrol 5: 1273-1287, 1994
26. Kriz W, Hosser H, Hahnel B, Gretz N, Provoost AP: From segmental glomerulosclerosis to total nephron degeneration and interstitial fibrosis: A histopathological study in rat models and human glomerulopathies. Nephrol Dial Transplant 13: 2781-2798, 1998
27. Kriz W, Gretz N, Lemley KV: Progression of glomerular disease: Is the podocyte the culprit? Kidney Int 54: 345-351, 1998
28. Gassler N, Elger M, Kränzlin B, Kriz W, Gretz N: Podocyte injury underlies the progression of focal segmental glomerulosclerosis in the fa/fa Zucker rat. Kidney Int 60: 106-116, 2001
29. Abbate M, Zoja C, Rottoli D, Corna D, Tomasoni S, Remuzzi G: Proximal tubular cells promote fibrogenesis by TGF-beta 1-mediated induction of peritubular myofibroblasts. Kidney Int 61: 2066-2077, 2002
30. Zandi-Nejad K, Eddy AA, Glassock RJ, Brenner BM: Why is proteinuria an ominous biomarker of progressive kidney disease? Kidney Int Suppl 92: S76-S89, 2004
31. Drummond K, Mauer M: The early natural history of nephropathy in type 1 diabetes. II. Early renal structural changes in type 1 diabetes. Diabetes 15: 1580-1587, 2002