Differential blood lipid-lowering effects of alkylsulfonated chitosan of different molecular weights in Syrian hamsters in vivo

Molecular Medicine Reports

Volumn 5, Issue 3, 2012, Pages 688-694

  Wu, Chih Chung ^a   Lin, Shan Ying ^b   Chen, Chi Tsai ^c   Chang, Yueh Ping ^d   Huang, Yun Shsan ^a   Lii, Chong Kuei ^e   Yu, Chien Chih ^e   Hsieh, Shu Ling ^f   Chung, Jing Gung ^e,g  

^a CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

^b Innovation Development Center   (Taiwan)

^c CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^d FOOYIN UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f NATIONAL KAOHSIUNG UNIVERSITY OF APPLIED SCIENCES   (Taiwan)

^g ASIA UNIVERSITY   (Taiwan)

Author keywords

Acyl coenzyme A:cholesterol acyltransferase 2; Blood lipids; Chitosan; Hamsters

Indexed keywords

ALKYLSULFONATED CHITOSAN; CELL ADHESION MOLECULE; CHITOSAN; CHOLESTEROL ACYLTRANSFERASE; FECES LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FECES LEVEL; HAMSTER; HEART; IN VIVO STUDY; INTESTINE ABSORPTION; KIDNEY; LIPID ABSORPTION; LIPID BLOOD LEVEL; LIPID DIET; LIVER; MALE; MOLECULAR WEIGHT; NONHUMAN; SPLEEN;

ALKYLATION; ANIMALS; ANTICHOLESTEREMIC AGENTS; CHITOSAN; CHOLESTEROL; CHOLESTEROL, LDL; CHOLESTEROL, VLDL; CRICETINAE; DIET, HIGH-FAT; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTESTINES; LIVER; LOVASTATIN; MESOCRICETUS; MOLECULAR WEIGHT; STEROL O-ACYLTRANSFERASE; SULFONIC ACIDS; TRIGLYCERIDES;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 84863082249     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.705     Document Type: Article

References (44)

1. Lee E, Kim H, Lee IH and Jon S: In vivo antitumor effects of chitosan-conjugated docetaxel after oral administration. J Control Release 140: 79-85, 2009.
2. Yuan WP, Liu B, Liu CH, et al: Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats. World J Gastroenterol 15: 1339-1345, 2009.
3. Chiang MT, Yao HT and Chen HC: Effect of dietary chitosans with different viscosity on plasma lipids and lipid peroxidation in rats fed on a diet enriched with cholesterol. Biosci Biotechnol Biochem 64: 965-971, 2000.
4. Mhurchu CN, Poppitt SD, McGill AT, et al: The effect of the dietary supplement, chitosan, on body weight: a randomised controlled trial in 250 overweight and obese adults. Int J Obes Relat Metab Disord 28: 1149-1156, 2004. (Pubitemid 39141553)
5. No HK, Park NY, Lee SH and Meyers SP: Antibacterial activity of chitosans and chitosan oligomers with different molecular weights. Int J Food Microbiol 74: 65-72, 2002. (Pubitemid 34203704)
6. Sumiyoshi M and Kimura Y: Low molecular weight chitosan inhibits obesity induced by feeding a high-fat diet long-term in mice. J Pharm Pharmacol 58: 201-207, 2006. (Pubitemid 43164276)
7. Rodriguez MS and Albertengo LE: Interaction between chitosan and oil under stomach and duodenal digestive chemical conditions. Biosci Biotechnol Biochem 69: 2057-2062, 2005. (Pubitemid 41711826)
8. Gallaher DD, Gallaher CM, Mahrt GJ, et al: A glucomannan and chitosan fiber supplement decreases plasma cholesterol and increases cholesterol excretion in overweight normocholesterolemic humans. J Am Coll Nutr 21: 428-433, 2002.
9. Qin C, Du Y, Xiao L, Li Z and Gao X: Enzymic preparation of water-soluble chitosan and their antitumor activity. Int J Biol Macromol 31: 111-117, 2002. (Pubitemid 36143614)
10. Razdan A and Pettersson D: Effect of chitin and chitosan on nutrient digestibility and plasma lipid concentrations in broiler chickens. Br J Nutr 72: 277-288, 1994. (Pubitemid 24255088)
11. LeHoux JG and Grondin F: Some effects of chitosan on liver function in the rat. Endocrinology 132: 1078-1084, 1993.
12. Sugano M, Fujikawa T, Hiratsuji Y, Nakashima K, Fukuda N and Hasegawa Y: A novel use of chitosan as a hypocholesterolemic agent in rats. Am J Clin Nutr 33: 787-793, 1980. (Pubitemid 10077666)
13. Mun S, Decker EA and McClements DJ: Effect of molecular weight and degree of deacetylation of chitosan on the formation of oil-in-water emulsions stabilized by surfactant-chitosan membranes. J Colloid Interface Sci 296: 581-590, 2006.
14. Pervaiz SM and Abdul Haleem M: Studies on the structure of beta-chitin, I. Z Naturforsch C 30: 571-574, 1975.
15. Luskey KL: Regulation of cholesterol synthesis: mechanism for control of HMG CoA reductase. Recent Prog Horm Res 44: 35-51, 1988.
16. Goldstein JL and Brown MS: Regulation of the mevalonate pathway. Nature 343: 425-430, 1990.
17. Lei YP, Chen HW, Sheen LY and Lii CK: Diallyl disulfide and diallyl trisulfide suppress oxidized LDL--induced vascular cell adhesion molecule and E-selectin expression through protein kinase A- and B-dependent signaling pathways. J Nutr 138: 996-1003, 2008.
18. Sung JH, Lee SJ, Park KH and Moon TW: Isoflavones inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. Biosci Biotechnol Biochem 68: 428-432, 2004. (Pubitemid 39251545)
19. Liu L and Yeh YY: S-alk(en)yl cysteines of garlic inhibit cholesterol synthesis by deactivating HMG-CoA reductase in cultured rat hepatocytes. J Nutr 132: 1129-1134, 2002. (Pubitemid 34606439)
20. Chang TY, Chang CC, Lin S, Yu C, Li BL and Miyazaki A: Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2. Curr Opin Lipidol 12: 289-296, 2001.
21. Chang TY, Chang CC and Cheng D: Acyl-coenzyme A:cholesterol acyltransferase. Annu Rev Biochem 66: 613-638, 1997.
22. Miyazaki A, Sakashita N, Lee O, et al: Expression of ACAT-1 protein in human atherosclerotic lesions and cultured human monocytes-macrophages. Arterioscler Thromb Vasc Biol 18: 1568-1574, 1998. (Pubitemid 28465408)
23. Choi JH, Rho MC, Lee SW, et al: Bavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia. Arch Pharm Res 31: 1419-1423, 2008.
24. Han C, Chen X, Xie W, et al: Determination of hexabromocyclododecane diastereoisomers in Sargassum fusiforme and comparison of the extraction efficiency of ultrasonication, microwave-assisted extraction, Soxhlet extraction and pressurised liquid extraction. J Sep Sci 33: 3319-3325, 2010.
25. Towbin H, Staehelin T and Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354, 1979. (Pubitemid 9256559)
26. Zhang J, Liu J, Li L and Xia W: Dietary chitosan improves hypercholesterolemia in rats fed high-fat diets. Nutr Res 28: 383-390, 2008. (Pubitemid 351718471)
27. Razdan A and Pettersson D: Hypolipidaemic, gastrointestinal and related responses of broiler chickens to chitosans of different viscosity. Br J Nutr 76: 387-397, 1996. (Pubitemid 26333983)
28. Ebihara K and Schneeman BO: Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. J Nutr 119: 1100-1106, 1989. (Pubitemid 19244288)
29. Nestel PJ: Effects of dairy fats within different foods on plasma lipids. J Am Coll Nutr 27: 735S-740S, 2008.
30. Katcher HI, Hill AM, Lanford JL, Yoo JS and Kris-Etherton PM: Lifestyle approaches and dietary strategies to lower LDL-cholesterol and triglycerides and raise HDL-cholesterol. Endocrinol Metab Clin North Am 38: 45-78, 2009.
31. Nam KS, Kim MK and Shon YH: Inhibition of proinflammatory cytokine-induced invasiveness of HT-29 cells by chitosan oligosaccharide. J Microbiol Biotechnol 17: 2042-2045, 2007.
32. Cho EJ, Rahman MA, Kim SW, et al: Chitosan oligosaccharides inhibit adipogenesis in 3T3-L1 adipocytes. J Microbiol Biotechnol 18: 80-87, 2008.
33. Nam KS, Kim MK and Shon YH: Chemopreventive effect of chitosan oligosaccharide against colon carcinogenesis. J Microbiol Biotechnol 17: 1546-1549, 2007.
34. Katsuren K, Tamura T, Arashiro R, et al: Structure of the human acyl-CoA:cholesterol acyltransferase-2 (ACAT-2) gene and its relation to dyslipidemia. Biochim Biophys Acta 1531: 230-240, 2001. (Pubitemid 32452427)
35. Jeon SM, Kim HK, Kim HJ, et al: Hypocholesterolemic and antioxidative effects of naringenin and its two metabolites in high-cholesterol fed rats. Transl Res 149: 15-21, 2007. (Pubitemid 44969644)
36. Choi MS, Lee MK, Jung UJ, et al: Metabolic response of soy pinitol on lipid-lowering, antioxidant and hepatoprotective action in hamsters fed-high fat and high cholesterol diet. Mol Nutr Food Res 53: 751-759, 2009.
37. Galkina E and Ley K: Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol 27: 2292-2301, 2007. (Pubitemid 350203942)
38. Stangl V, Lorenz M, Ludwig A, et al: The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets. J Nutr 135: 172-178, 2005. (Pubitemid 40194474)
39. Gourdin MJ, Bree B and De Kock M: The impact of ischaemia-reperfusion on the blood vessel. Eur J Anaesthesiol 26: 537-547, 2009.
40. Bacun T, Glavas-Obrovac L, Belovari T, et al: Insulin administration in the mild hyperglycaemia changes expression of proinflammatory adhesion molecules on human aortic endothelial cells. Coll Antropol 34: 911-915, 2010.
41. Kita T, Kume N, Minami M, et al: Role of oxidized LDL in atherosclerosis. Ann NY Acad Sci 947: 199-206, 2001. (Pubitemid 34059914)
42. Kita T: Hyperlipidemia and atherosclerosis. Nihon Rinsho 60: 851-859, 2002.
43. Fang W, Zhang HX, Wang LY, et al: The effects of polygoni multiflori total glycosides on the experimentally atherosclerotic formation in apoE--deficient mice. Zhongguo Zhong Yao Za Zhi 30: 1542-1545, 2005. (Pubitemid 44795778)
44. Fang W, Zhang HX, Wang LY, et al: Effect of PMTG on atherosclerotic lesion formation and expression of ICAM-1 and VCAM-1 in ApoE-deficient mice. Zhongguo Zhong Yao Za Zhi 32: 1320-1323, 2007.