Structure of the human acyl-CoA:cholesterol acyltransferase-2 (ACAT-2) gene and its relation to dyslipidemia

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1531, Issue 3, 2001, Pages 230-240

  Katsuren, Keisuke ^a   Tamura, Toshiya ^a   Arashiro, Rina ^a   Takata, Kouki ^b   Matsuura, Toshinobu ^a   Niikawa, Norio ^c   Ohta, Takao ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b HIROSHIMA GENERAL HOSPITAL   (Japan)

^c NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acyl coenzyme A:cholesterol acyltransferase 2; Apolipoprotein C III; Atherosclerosis; Cholesterol esterification; Dyslipidemia; Lipoprotein

Indexed keywords

APOLIPOPROTEIN C3; CHOLESTEROL ACYLTRANSFERASE; COMPLEMENTARY DNA; DNA; DNA BASE; DNA FRAGMENT; ISOENZYME; LIPID; PRIMER DNA; TRIACYLGLYCEROL;

ARTICLE; CHROMOSOME; CONSENSUS SEQUENCE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DETERMINATION; DNA SEQUENCE; DOT HYBRIDIZATION; DYSLIPIDEMIA; EXON; GENE EXPRESSION; GENE STRUCTURE; HETEROZYGOTE; HUMAN; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MISSENSE MUTATION; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

APOLIPOPROTEINS; BASE SEQUENCE; DNA; EXONS; GENE LIBRARY; GENETIC SCREENING; GENOTYPE; HUMANS; HYPERLIPIDEMIAS; ISOENZYMES; LEUKOCYTES; LIPIDS; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; STEROL O-ACYLTRANSFERASE;

EID: 0035971549     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(01)00106-8     Document Type: Article

References (29)

1. Yao Z., McLeod R.S. Synthesis and secretion of hepatic apolipoprotein B-containing lipoproteins. Biochim. Biophys. Acta. 1212:1994;152-166.
2. Sniderman A.D., Cianflone K. Substrate delivery as a determinant of hepatic apo B secretion. Arterioscler. Thromb. Vasc. Biol. 13:1993;629-636.
3. Thompson G.R., Naoumova R.P., Watts G.F. Role of cholesterol in regulating apolipoprotein B secretion by the liver. J. Lipid Res. 37:1996;439-447.
4. Cases S., Novak S., Zheng Y.W., Myers H.M., Lear S.R., Sande E., Welch C.B., Lusis A.J., Spencer T.A., Krause B.R., Erickson S.K., Farese R.V. Jr. ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. J. Biol. Chem. 273:1998;26755-26764.
5. Anderson R.A., Joyce C., Davis M., Reagan J.W., Clark M., Shelness G.S., Rudel L.L. Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates. J. Biol. Chem. 273:1998;26747-26754.
6. Tabas I. The stimulation of the cholesterol esterification pathway by atherogenic lipoproteins in macrophages. Curr. Opin. Lipidol. 6:1995;260-268.
7. Miyazaki A., Sakashita N., Lee O., Takahashi K., Horiuchi S., Hakamata H., Morganelli P.M., Chang C.C.Y., Chang T.Y. Expression of ACAT-1 protein in human atherosclerotic lesions and cultured human monocytes-macrophages. Arterioscler. Thromb. Vasc. Biol. 18:1998;1568-1574.
8. Rudel L.L., Johnson F.L., Sawyer J.K., Wilson M.S., Parks J.S. Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness. Am. J. Clin. Nutr. 62:1995;463S-470S.
9. Rudel L.L., Haines J., Sawyer J.K., Shah R., Wilson M.S., Carr T.P. Hepatic origin of cholesteryl oleate in coronary artery atherosclerosis in African green monkeys. J. Clin. Invest. 100:1997;74-83.
10. Oelkers P., Behari A., Cromley D., Billheimer J.T., Sturley S.L. Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. J. Biol. Chem. 273:1998;26765-26771.
11. Chang C.C.Y., Huh H.Y., Cadigan K.M., Chang T.-Y. Molecular cloning and functional expression of human acyl-coA:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. J. Biol. Chem. 268:1993;20747-20755.
12. Uelmen P.J., Oka K., Sullivan M., Chang C.C.Y., Chang T.-Y., Chan L. Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase in mice. J. Biol. Chem. 270:1995;26192-26201.
13. Pape M.E., Schultz P.A., Rea T.J., DeMattos R.B., Kieft K., Bisgaier C.L., Newton R.S., Krause B.R. Tissue specific changes in ACAT mRNA levels in rabbits. J. Lipid Res. 36:1995;823-838.
14. Chang C.C.Y., Sakashita N., Ornvold K., Lee O., Chang E.T., Dong R., Lin S., Lee C.Y.G., Strom S., Kashyap R., Fung J., Farese R.V. Jr., Patoiseau J.F., Delhon A., Chang T.-Y. Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine. J. Biol. Chem. 275:2000;28083-28092.
15. Kusunoki J., Aragane K., Kitamine T., Kozono H., Kano K., Fujinami K., Kojima K., Chiwata T., Sekine Y. Postprandial hyperlipidemia in streptozotocin-induced diabetic rats is due to abnormal increase in intestinal acyl coenzyme A:cholesterol acyltransferase activity. Arterioscler. Thromb. Vasc. Biol. 20:2000;171-178.
16. Li B.L., Li X.L., Duan Z.J., Lee O., Lin S., Ma Z.M., Chang C.C.Y., Yang X.Y., Park J.P., Mohandas T.K., Noll W., Chan L., Chang T.-Y. Human acyl-coA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes. J. Biol. Chem. 274:1999;11060-11071.
17. Matsumoto N., Soeda E., Ohashi H., Fujimoto M., Kato R., Tsujita T., Tomita H., Kondo S., Fukushima Y., Niikawa N. A 1.2-megabase BAC/PAC contig spanning the 14q13 breakpoint of t (2;14) in a mirror-image polydactyly patient. Genomics. 45:1997;11-16.
18. J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular Cloning: a Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.
19. Orita M., Suzuki Y., Sekiya T., Hayashi K. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics. 5:1989;874-879.
20. Burnstein M., Scholnick H.R., Morfin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J. Lipid Res. 11:1970;583-595.
21. Warnick G.R., Nguyen T., Albers A.A. Comparison of improved precipitation methods for quantification of high density lipoprotein cholesterol. Clin. Chem. 31:1985;217-222.
22. Goto Y., Akanuma Y., Harano Y., Itakura H. Determination by SRID methods of normal values of serum apolipoprotein (A-I, A-II, B, C-II, C-III, and E) in normolipidemic healthy Japanese subjects. J. Clin. Biochem. Nutr. 1:1986;73-88.
23. Lee O., Chang C.C.Y., Lee W., Chang T.-Y. Immunodepletion experiments suggest that ACAT-1 protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines. J. Lipid Res. 39:1998;1722-1727.
24. Buhman K.K., Accad M., Novak S., Choi R.S., Wong J.S., Hamilton R.L., Turley S., Farese R.V. Jr. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT-2 deficient mice. Nat. Med. 6:2000;1341-1347.
25. Wang C.S., McConathy W.J., Kloer H.U., Alaupovic P. Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III. J. Clin. Invest. 75:1985;384-390.
26. Windler E., Havel R.J. Inhibitory effects of C apolipoproteins from rats and humans on the uptake of TG-rich lipoproteins and their remnants by the perfused rat liver. J. Lipid Res. 26:1985;556-565.
27. Ito Y., Azrolan N., O'Connell A., Walsh A., Breslow J.L. Hypertriglyceridemia as a result of human apolipoprotein C-III gene expression in transgenic mice. Science. 249:1990;790-793.
28. Hayek T., Azrolan N., Verdery R.B., Walsh A., Chajek-Shaul T., Agellon L.B., Tall A.R., Breslow J.L. Hypertriglyceridemia and cholesteryl ester transfer protein interact to dramatically alter high density lipoprotein levels, particle sizes, and metabolism. Studies in transgenic mice. J. Clin. Invest. 92:1993;1143-1152.
29. Lee R.G., Willingham M.C., Davis M.A., Skinner K.A., Rudel L.L. Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates. J. Lipid Res. 41:2000;1991-2001.