Investigation of the catalytic mechanism of the hotdog-fold enzyme superfamily pseudomonas sp. strain CBS3 4-hydroxybenzoyl-CoA thioesterase

Biochemistry

Volumn 51, Issue 3, 2012, Pages 786-794

  Zhuang, Zhihao ^a,c   Latham, John ^a   Song, Feng ^a,d   Zhang, Wenhai ^a,e   Trujillo, Michael ^b   Dunaway Mariano, Debra ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b NEW MEXICO DEPARTMENT OF HEALTH   (United States)

^c UNIVERSITY OF DELAWARE   (United States)

^d SYNGENTA CROP PROTECTION   (United States)

^e MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CARBONYL CARBON ATOMS; CATALYTIC MECHANISMS; COENZYME A; DEGRADATION PATHWAYS; ENZYME SUPERFAMILIES; HYDROLYTIC CLEAVAGE; KINETIC MODELS; MICROSCOPIC RATE CONSTANTS; NUCLEOPHILIC CATALYSIS; PRODUCT INHIBITION; PRODUCT RELEASE; PSEUDOMONAS SP; RATE LIMITING; RATE-LIMITING STEPS; SIMULATION-BASED; SOLVENT KINETIC ISOTOPE EFFECTS; STEADY STATE REACTIONS; STRUCTURAL DATA; SUBSTRATE BINDING; SUBSTRATE COMPLEXES; SUBSTRATE-BOUND; THIOESTERASES; TIME COURSE; WILD TYPES; X RAY STRUCTURAL ANALYSIS; X-RAY CRYSTALLOGRAPHIC ANALYSIS;

BACTERIA; BINDING SITES; CATALYSIS; COMPUTER SIMULATION; ISOTOPES; KINETICS; QUANTUM CHEMISTRY; REACTION INTERMEDIATES; X RAY CRYSTALLOGRAPHY; X RAYS;

RATE CONSTANTS;

4 HYDROXYBENZOYL COENZYME A THIOESTERASE; CARBON 14; COENZYME A; DEUTERIUM OXIDE; ISOTOPE; PROTON; SOLVENT; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL STRAIN; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME RELEASE; ENZYME SUBSTRATE; HYDROLYSIS; MICROSCOPY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN METABOLISM; PROTON TRANSPORT; PSEUDOMONAS; SIGNAL TRANSDUCTION; STEADY STATE; TURNOVER TIME; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; CATALYTIC DOMAIN; CHLOROBENZOATES; COENZYME A; CRYSTALLOGRAPHY, X-RAY; HYDROLYSIS; LIGANDS; PARABENS; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PSEUDOMONAS; SUBSTRATE SPECIFICITY; THIOLESTER HYDROLASES;

PSEUDOMONAS SP.;

EID: 84863073940     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2013917     Document Type: Article

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