Isoflurane protects against human endothelial cell apoptosis by inducing sphingosine kinase-1 via ERK MAPK

International Journal of Molecular Sciences

Volumn 13, Issue 1, 2012, Pages 977-993

  Bakar, Adnan M ^a   Park, Sang Won ^a   Kim, Mihwa ^a   Lee, H Thomas ^a  

^a Department of Anesthesiology College of Physicians and Surgeons of Columbia University ^*  (United States)

Author keywords

EA.hy926; Extracellular signal regulated kinase; Necrosis; Sphingosine kinase; Volatile anesthetic

Indexed keywords

CELL DNA; HYDROGEN PEROXIDE; ISOFLURANE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; SPHINGOSINE KINASE 1; TUMOR NECROSIS FACTOR ALPHA; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; FLAVONOID; INHALATION ANESTHETIC AGENT; PHOSPHOTRANSFERASE; SPHINGOSINE KINASE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; DNA LADDERING; DNA STRUCTURE; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HUMAN; HUMAN CELL; NICK END LABELING; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; DNA FRAGMENTATION; DRUG EFFECTS; GENETICS; METABOLISM; NECROSIS; PHOSPHORYLATION; TOXICITY;

ANESTHETICS, INHALATION; APOPTOSIS; CELL LINE; DNA FRAGMENTATION; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HUMANS; HYDROGEN PEROXIDE; ISOFLURANE; NECROSIS; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863049159     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13010977     Document Type: Article

References (45)

1. Ait-Oufella, H.; Maury, E.; Lehoux, S.; Guidet, B.; Offenstadt, G. The endothelium: hysiological functions and role in microcirculatory failure during severe sepsis. Intensive Care Med. 2010, 36, 1286-1298.
2. Carden, D.L.; Granger, D.N. Pathophysiology of ischaemia-reperfusion injury. J. Pathol. 2000, 190, 255-266.
3. Stefanec, T. Endothelial apoptosis: Could it have a role in the pathogenesis and treatment of disease? Chest 2000, 117, 841-854.
4. Preckel, B.; Bolten, J. Pharmacology of modern volatile anaesthetics. Best Pract. Res. Clin. Anaesthesiol. 2005, 19, 331-348.
5. Lee, H.T.; Kim, M.; Jan, M.; Emala, C.W. Anti-inflammatory and antinecrotic effects of the volatile anesthetic sevoflurane in kidney proximal tubule cells. Am. J. Physiol. Ren. Physiol. 2006, 291, F67-F78.
6. Lochhead, K.M.; Zager, R.A. Fluorinated anesthetic exposure "activates" the renal cortical sphingomyelinase cascade. Kidney Int. 1998, 54, 373-381.
7. Hait, N.C.; Oskeritzian, C.A.; Paugh, S.W.; Milstien, S.; Spiegel, S. Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochim. Biophys. Acta 2006, 1758, 2016-2026.
8. de Klaver, M.J.; Manning, L.; Palmer, L.A.; Rich, G.F. Isoflurane pretreatment inhibits cytokine-induced cell death in cultured rat smooth muscle cells and human endothelial cells. Anesthesiology 2002, 97, 24-32.
9. Johnson, M.E.; Sill, J.C.; Uhl, C.B.; Halsey, T.J.; Gores, G.J. Effect of volatile anesthetics on hydrogen peroxide-induced injury in aortic and pulmonary arterial endothelial cells. Anesthesiology 1996, 84, 103-116.
10. Zhou, Y.; Lekic, T.; Fathali, N.; Ostrowski, R.P.; Martin, R.D.; Tang, J.; Zhang, J.H. Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway. Stroke 2010, 41, 1521-1527.
11. Cason, B.A.; Gamperl, A.K.; Slocum, R.E.; Hickey, R.F. Anesthetic-induced preconditioning: Previous administration of isoflurane decreases myocardial infarct size in rabbits. Anesthesiology 1997, 87, 1182-1190.
12. Kim, M.; Kim, M.; Kim, N.; D'Agati, V.D.; Emala, C.W.; Lee, H.T. Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathways. Am. J. Physiol. Ren. Physiol. 2007, 293, F1827-F1835.
13. Kim, M.; Kim, M.; Park, S.W.; Pitson, S.M.; Lee, H.T. Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. Am. J. Nephrol. 2010, 31, 353-362.
14. Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol. 2007, 35, 495-516.
15. Weber, N.C.; Kandler, J.; Schlack, W.; Grueber, Y.; Fradorf, J.; Preckel, B. Intermitted pharmacologic pretreatment by xenon, isoflurane, nitrous oxide, and the opioid morphine prevents tumor necrosis factor alpha induced adhesion molecule expression in human umbilical vein endothelial cells. Anesthesiology 2008, 108, 199-207.
16. de Klaver, M.J.; Buckingham, M.G.; Rich, G.F. Isoflurane pretreatment has immediate and delayed protective effects against cytokine-induced injury in endothelial and vascular smooth muscle cells. Anesthesiology 2003, 99, 896-903.
17. Lee, H.T.; Emala, C.W. Adenosine attenuates oxidant injury in human kidney proximal tubular cells via A1 and A2a adenosine receptor activation. Am. J. Physiol. Ren. Physiol. 2002, 282, F844-F852.
18. Kim, M.; Park, S.W.; Kim, M.; D'Agati V.D.; Lee, H.T. Isoflurane protects against intestinal ischemia-reperfusion injury and multi-organ dysfunction via transforming growth factor-beta1. Ann. Surg. 2011, in press.
19. Venkataraman, K.; Lee, Y.M.; Michaud, J.; Thangada, S.; Ai, Y.; Bonkovsky, H.L.; Parikh, N.S.; Habrukowich, C.; Hla, T. Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ. Res. 2008, 102, 669-676.
20. Jo, S.K.; Bajwa, A.; Awad, A.S.; Lynch, K.R.; Okusa, M.D. Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease. Kidney Int. 2008, 73, 1220-1230.
21. Liu, H.; Chakravarty, D.; Maceyka, M.; Milstien, S.; Spiegel, S. Sphingosine kinases: A novel family of lipid kinases. Prog. Nucleic Acid Res. Mol. Biol. 2002, 71, 493-511.
22. Olivera, A.; Kohama, T.; Edsall, L.; Nava, V.; Cuvillier, O.; Poulton, S.; Spiegel, S. Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J. Cell Biol. 1999, 147, 545-558.
23. Moriue, T.; Igarashi, J.; Yoneda, K.; Nakai, K.; Kosaka, H.; Kubota, Y. Sphingosine 1-phosphate attenuates H2O2-induced apoptosis in endothelial cells. Biochem. Biophys. Res. Commun. 2008, 368, 852-857.
24. Kimura, T.; Sato, K.; Kuwabara, A.; Tomura, H.; Ishiwara, M.; Kobayashi, I.; Ui, M.; Okajima, F. Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. J. Biol. Chem. 2001, 276, 31780-31785.
25. Vessey, D.A.; Kelley, M.; Li, L.; Huang, Y.; Zhou, H.Z.; Zhu, B.Q.; Karliner, J.S. Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury. Med. Sci. Monit. 2006, 12, BR318-BR324.
26. Kon, S.; Imai, M.; Inaba H. Isoflurane attenuates early neutrophil independent hypoxia-reoxygenation injuries in the reperfused liver in fasted rats. Anesthesiology 1997, 86, 128-136.
27. Awad, A.S.; Ye, H.; Huang, L.; Li, L.; Foss, F.W.; Macdonald, T.L.; Lynch, K.R.; Okusa, M.D. Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. Am. J. Physiol. Ren. Physiol. 2006, 290, F1516-F1524.
28. Kolch, W. Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem. J. 2000, 351, 289-305.
29. Wu, J.; Spiegel, S.; Sturgill, T.W. Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism. J. Biol. Chem. 1995, 270, 11484-11488.
30. Kersten, J.R.; Schmeling, T.J.; Pagel, P.S.; Gross, G.J.; Warltier, D.C. Isoflurane mimics ischemic preconditioning via activation of K(ATP) channels: Reduction of myocardial infarct size with an acute memory phase. Anesthesiology 1997, 87, 361-370.
31. Shayevitz, J.R.; Rodriguez, J.L.; Gilligan, L.; Johnson, K.J.; Tait, A.R. Volatile anesthetic modulation of lung injury and outcome in a murine model of multiple organ dysfunction syndrome. Shock 1995, 4, 61-67.
32. Stratmann, G.; Sall, J.W.; May, L.D.; Bell, J.S.; Magnusson, K.R.; Rau, V.; Visrodia, K.H.; Alvi, R.S.; Ku, B.; Lee, M.T, et al. Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats. Anesthesiology 2009, 110, 834-848.
33. Head, B.P.; Patel, H.H.; Niesman, I.R.; Drummond, J.C.; Roth, D.M.; Patel, P.M. Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology 2009, 110, 813-825.
34. Lemkuil, B.P.; Head, B.P.; Pearn, M.L.; Patel, H.H.; Drummond, J.C.; Patel, P.M. Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin depolymerization. Anesthesiology 2011, 114, 49-57.
35. Jevtovic-Todorovic, V.; Hartman, R.E.; Izumi, Y.; Benshoff, N.D.; Dikranian, K.; Zorumski, C.F.; Olney, J.F.; Wozniak, D.F. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J. Neurosci. 2003, 23, 876-882.
36. Levin, E.D.; Uemura, E.; Bowman, R.E. Neurobehavioral toxicology of halothane in rats. Neurotoxicol. Teratol. 1991, 13, 461-470.
37. Chi, O.Z.; Hunter, C.; Liu, X.; Weiss, H.R. The effects of isoflurane pretreatment on cerebral blood flow, capillary permeability, and oxygen consumption in focal cerebral ischemia in rats. Anesth. Analg. 2010, 110, 1412-1418.
38. Li, L.; Zuo, Z. Isoflurane preconditioning improves short-term and long-term neurological outcome after focal brain ischemia in adult rats. Neuroscience 2009, 164, 497-506.
39. Statler, K.D.; Alexander, H.; Vagni, V.; Holubkov, R.; Dixon, C.E.; Clark, R.S.; Jenkins, L.; Kochanek, P.M. Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury. Brain Res. 2006, 1076, 216-224.
40. Statler, K.D.; Alexander, H.; Vagni, V.; Dixon, C.E.; Clark, R.S.; Jenkins, L.; Kochanek, P.M. Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. J. Neurotrauma 2006, 23, 97-108.
41. Edgell, C.J.; McDonald, C.C.; Graham, J.B. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc. Natl. Acad. Sci. USA 1983, 80, 3734-3737.
42. Herrmann, M.; Lorenz, H.M.; Voll, R.; Grunke, M.; Woith, W.; Kalden, J.R. A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res. 1994, 22, 5506-5507.
43. Lee, H.T.; Ota-Setlik, A.; Fu, Y.; Nasr, S.H.; Emala, C.W. Differential protective effects of volatile anesthetics against renal ischemia-reperfusion injury in vivo. Anesthesiology 2004, 101, 1313-1324.
44. Vessey, D.A.; Kelley, M.; Karliner, J.S. A rapid radioassay for sphingosine kinase. Anal. Biochem. 2005, 337, 136-142.
45. Min, J.K.; Yoo, H.S.; Lee, E.Y.; Lee, W.J.; Lee, Y.M. Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by ophthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase. Anal. Biochem. 2002, 303, 167-175.