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Volumn 7, Issue 2, 2012, Pages 273-280

Discovery and Characterization of Atropisomer PH-797804, a p38 MAP Kinase Inhibitor, as a Clinical Drug Candidate

(13) Xing, Li a Devadas, Balekudru a Devraj, Rajesh V a Selness, Shaun R a Shieh, Huey a Walker, John K a Mao, Michael a Messing, Dean a Samas, Brian a Yang, Jerry Z a Anderson, Gary D a Webb, Elizabeth G a Monahan, Joseph B a

a PFIZER INC (United States)

Author keywords

Atropisomers; Inhibitors; Interconversion; Kinases; Pyridinones

Indexed keywords

3 [3 BROMO 4 [(2,4 DIFLUOROBENZYL)OXY] 6 METHYL 2 OXOPYRIDIN 1 (2H)] N, 4 DIMETHYLBENZAMIDE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PH 797804; UNCLASSIFIED DRUG;

ARTICLE; CHIRAL CHROMATOGRAPHY; CONFORMATIONAL TRANSITION; DRUG BINDING; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; RAT; ROOM TEMPERATURE; X RAY DIFFRACTION;

ANIMALS; ARTHRITIS; BENZAMIDES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; FEMALE; LIPOPOLYSACCHARIDES; MALE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PYRIDONES; QUANTUM THEORY; RATS; RECEPTORS, CELL SURFACE;

EID: 84863040887 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201100439 Document Type: Article

Times cited : (32)

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