Predictive role of multilocus genetic polymorphisms in cardiovascular disease and inflammation-related genes on chronic kidney disease in Type 2 diabetes-an 8-year prospective cohort analysis of 1163 patients

Nephrology Dialysis Transplantation

Volumn 27, Issue 1, 2012, Pages 190-196

  Wang, Ying ^a   Luk, Andrea O Y ^a   Ma, Ronald C W ^a   So, Wing Yee ^a   Tam, Claudia H T ^a   Ng, Maggie C Y ^a   Yang, Xilin ^a   Lam, Vincent ^a   Tong, Peter C Y ^a   Chan, Juliana C N ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

diabetic kidney disease; gene polymorphism; haemostasis; inflammation; lipid metabolism

Indexed keywords

ALBUMIN; CREATININE;

ADULT; AGED; ALBUMIN TO CREATININE RATIO; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CETP GENE; CHINESE; CHRONIC KIDNEY DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; GENE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GLOMERULUS FILTRATION RATE; GLYCEMIC CONTROL; HEMOSTASIS; HUMAN; INFLAMMATION; ITGA2 GENE; LIPID ANALYSIS; LIPID METABOLISM; LTA GENE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PON1 GENE; PON2 GENE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RENAL SYSTEM PARAMETERS; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; COHORT STUDIES; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW-UP STUDIES; GLOMERULAR FILTRATION RATE; HUMANS; INFLAMMATION; KIDNEY FAILURE, CHRONIC; KIDNEY FUNCTION TESTS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 84863039362     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr343     Document Type: Article

References (41)

1. Bakris GL, Weir MR, Shanifar S et al. Effects of blood pressure level on progression of diabetic nephropathy: results from the RENAAL study. Arch Intern Med 2003; 163: 1555-1565 (Pubitemid 36835100)
2. Bash LD, Selvin E, Steffes M et al. Poor glycemic control in diabetes and the risk of incident chronic kidney disease Even in the absence of albuminuria and retinopathy: atherosclerosis risk in Communities (ARIC) study. Arch Intern Med 2008; 168: 2440-2447
3. Luk A O, So W Y, Ma R C et al. Metabolic syndrome predicts New onset of chronic kidney disease in 5,829 patients with type 2 diabetes. Diabetes Care 2008; 31: 2357-2361
4. Wu A Y, Kong N C, de Leon F A et al. An alarmingly high prevalence of diabetic nephropathy in Asian type 2 diabetic patients: the Micro-Albuminuria Prevalence (MAP) Study. Diabetologia 2005; 48: 17-26 (Pubitemid 40174652)
5. Clustering of long-term complications in families with diabetes in the diabetes control and complications trial. The Diabetes Control and Complications Trial Research Group. Diabetes 1997; 46: 1829-1839
6. Yang X, Ma R, So WY et al. Impacts of chronic kidney disease and albuminuria on associations between coronary heart disease and its traditional risk factors in type 2 diabetic patients-the Hong Kong diabetes registry. Cardiovasc Diabetol 2007; 6: 37
7. Ma YC, Zuo L, Chen JH et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 2006; 17: 2937-2944 (Pubitemid 44484685)
8. Cheng S, Grow MA, Pallaud C et al. A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res 1999; 9: 936-949 (Pubitemid 29525202)
9. Sladek R, Rocheleau G, Rung J et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007; 445: 881-885
10. Purcell S, Cherny SS, Sham PC. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003; 19: 149-150 (Pubitemid 36150192)
11. Song XY, Lee SY, Ma RC et al. Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling. Diabetologia 2009; 52: 1543-1553
12. Abrass CK. Cellular lipid metabolism and the role of lipids in Progressive renal disease. Am J Nephrol 2004; 24: 46-53 (Pubitemid 38258276)
13. Schaeffner ES, Kurth T, Curhan GC et al. Cholesterol and the risk of renal dysfunction in apparently healthy men. J Am Soc Nephrol 2003; 14: 2084-2091 (Pubitemid 36909916)
14. Yamashita S, Hirano K, Sakai N et al. Molecular biology and path-ophysiological aspects of plasma cholesteryl ester transfer protein. Biochim Biophys Acta 2000; 1529: 257-275
15. Drayna D, Jarnagin A S, McLean J et al. Cloning and sequencing of human cholesteryl ester transfer protein cDNA. Nature 1987; 327: 632-634 (Pubitemid 17086900)
16. Thompson A, Di Angelantonio E, Sarwar N et al. Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA 2008; 299: 2777-2788 (Pubitemid 351846853)
17. Kahri J, Groop P H, Elliott T et al. Plasma cholesteryl ester transfer protein and its relationship to plasma lipoproteins and apolipoprotein A-I-containing lipoproteins in IDDM patients with microalbuminuria and clinical nephropathy. Diabetes Care 1994; 17: 412-419
18. Hadjadj S, Gallois Y, Simard G et al. Lack of relationship in long-term type 1 diabetic patients between diabetic nephropathy and polymorphisms in apolipoprotein epsilon, lipoprotein lipase and cholesteryl ester transfer protein. Nephrol Dial Transplant 2000; 15: 1971-1976
19. Primo-Parmo SL, Sorenson RC, Teiber J et al. The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics 1996; 33: 498-507 (Pubitemid 26159866)
20. Aviram M, Rosenblat M, Bisgaier CL et al. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Invest 1998; 101: 1581-1590 (Pubitemid 28198486)
21. Flekac M, Skrha J, Źidková K et al. Paraoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus. Physiol Res 2008; 57: 717-726
22. Araki S, Makita Y, Canani L et al. Polymorphisms of human para-oxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in type I diabetes mellitus. Diabetologia 2000; 43: 1540-1543 (Pubitemid 32734861)
23. Kao Y, Donaghue KC, Chan A et al. Paraoxonase gene cluster is a genetic marker for early microvascular complications in Type 1 diabetes. Diabet Med 2002; 19: 212-215 (Pubitemid 34429651)
24. Ng CJ, Wadleigh DJ, Gangopadhyay A et al. Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein. J Biol Chem 2001; 276: 44444-44449
25. Baynes JW, Thorpe SR. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 1999; 48: 1-9 (Pubitemid 29019345)
26. Mackness B, McElduff P, Mackness M I. The paraoxonase-2-310 polymorphism is associated with the presence of microvascular complications in diabetes mellitus. J Intern Med 2005; 258: 363-368
27. Pinizzotto M, Castillo E, Fiaux M et al. Paraoxonase2 polymorphisms are associated with nephropathy in Type II diabetes. Diabetologia 2001; 44: 104-107 (Pubitemid 32141891)
28. Campbell R D, Trowsdale J. Map of the human MHC. Immunol Today 1993; 14: 347-352
29. Messer G, Spengler U, Jung M C et al. Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. J Exp Med 1991; 173: 209-219
30. Ozaki K, Ohnishi Y, Iida A et al. Functional SNPs in the lympho-toxin-[alpha] gene that are associated with susceptibility to myocar-dial infarction. Nat Genet 2002; 32: 650-654 (Pubitemid 35435179)
31. Suzuki G, Izumi S, Hakoda M et al. LTA 252G allele containing haplotype block is associated with high serum C-reactive protein levels. Atherosclerosis 2004; 176: 91-94 (Pubitemid 39078649)
32. Jang Y, Koh SJ, Kim OY et al. Effect of the 252A>G polymorphism of the lymphotoxin-alpha gene on inflammatory markers of response to cigarette smoking in Korean healthy men. Clin Chim Acta 2007; 377: 221-227 (Pubitemid 44908256)
33. Jang Y, Kim H J, Koh S J et al. Lymphotoxin-alpha gene 252A>G and metabolic syndrome features in Korean men with coronary artery disease. Clin Chim Acta 2007; 384: 124-128 (Pubitemid 47247423)
34. Wang X, Cheng S, Brophy VH et al. A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. Stroke 2009; 40: 683-695
35. Tong PC, Lee KF, So WY et al. White blood cell count is associated with macro-and microvascular complications in Chinese patients with type 2 diabetes. Diabetes Care 2004; 27: 216-222 (Pubitemid 38196735)
36. Festa A, D'Agostino R, Howard G et al. Inflammation and micro-albuminuria in nondiabetic and type 2 diabetic subjects: The Insulin Resistance Atherosclerosis Study. Kidney Int 2000; 58: 1703-1710
37. Lindholm E, Bakhtadze E, Cilio C et al. Association between LTA, TNF and AGER polymorphisms and late diabetic complications. PLoS One 2008; 25: e2546
38. Kamata T, Puzon W, Takada Y. Identification of putative ligand binding sites within I domain of integrin alpha 2 beta 1 (VLA-2, CD49b/CD29). J Biol Chem 1994; 269: 9659-9663 (Pubitemid 24196565)
39. Kritzik M, Savage B, Nugent DJ et al. Nucleotide polymorphisms in the alpha 2 gene define multiple alleles that are associated with differences in platelet alpha 2beta 1 density. Blood 1998; 92: 2382-2388 (Pubitemid 28452981)
40. Matsubara Y, Murata M, Maruyama T et al. Association between diabetic retinopathy and genetic variations in alpha 2beta 1 integrin, a platelet receptor for collagen. Blood 2000; 95: 1560-1564 (Pubitemid 30120813)
41. Tsai D H, Jiang Y D, Wu K D et al. Platelet collagen receptor alpha2-beta1 integrin and glycoprotein IIIa PlA1/A2 polymorphisms are not associated with nephropathy in type 2 diabetes. Am J Kidney Dis 2001; 38: 1185-1190