Paraoxonase2 polymorphisms are associated with nephropathy in Type II diabetes

Diabetologia

Volumn 44, Issue 1, 2001, Pages 104-107

  Pinizzotto, M ^a   Castillo, E ^a   Fiaux, M ^a   Temler, E ^a   Gaillard, R C ^a   Ruiz, J ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Associati on study; Body mass index; Dyslipidaemia; Gene; Insulin resistance; Microalbuminuria; Nephropathy; Paraoxonase; Polymorphism; Type 2 diabetes mellitus

Indexed keywords

ARYLDIALKYLPHOSPHATASE;

ARTICLE; BODY MASS; CASE CONTROL STUDY; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; DYSLIPIDEMIA; FEMALE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; RISK FACTOR;

ARYLDIALKYLPHOSPHATASE; BODY MASS INDEX; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; ESTERASES; FEMALE; HOMOZYGOTE; HUMANS; LINKAGE DISEQUILIBRIUM; LOGISTIC MODELS; MALE; MULTIVARIATE ANALYSIS; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RISK FACTORS;

EID: 0035130263     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051586     Document Type: Article

References (9)

1. The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family
2. The molecular basis of the human serum paraoxonase activity polymorphism
3. Human PON2 gene at 7q21.3: Cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence
4. DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease
5. Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus
6. Development, multiplexing, and application of ARMS tests for common mutations in the CFTR gene
7. Cholesterol-lowering therapy may retard the progression of diabetic nephropathy
8. Albuminuria reflects widespread vascular damage. The Steno hypothesis