Conjugated linoleic acid induces hepatic expression of fibroblast growth factor 21 through PPAR-α

British Journal of Nutrition

Volumn 107, Issue 4, 2012, Pages 461-465

  Yu, Jie ^a   Yu, Bing ^a   Jiang, Honglin ^b   Chen, Daiwen ^a  

^a SICHUAN AGRICULTURAL UNIVERSITY   (China)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

Conjugated linoleic acid; Fibroblast growth factor 21; Liver; PPAR

Indexed keywords

CONJUGATED LINOLEIC ACID; FIBROBLAST GROWTH FACTOR 21; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SERUM ALBUMIN; SOYBEAN OIL;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST GROWTH FACTOR 21 GENE; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; LIVER METABOLISM; LIVER PARENCHYMA; MALE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE;

ANIMALS; ANTI-OBESITY AGENTS; CHO CELLS; CRICETINAE; DIETARY SUPPLEMENTS; FIBROBLAST GROWTH FACTORS; GENES, REPORTER; HEP G2 CELLS; HUMANS; LINOLEIC ACIDS, CONJUGATED; LIVER; MALE; MICE; MICE, INBRED C57BL; PPAR ALPHA; PROMOTER REGIONS, GENETIC; RECOMBINANT PROTEINS; RNA, MESSENGER; UP-REGULATION;

BOVINAE; MUS;

EID: 84863027790     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114511003205     Document Type: Article

References (27)

1. Badman MK, Pissios P, Kennedy AR, et al. (2007) Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 5, 426-437. (Pubitemid 46825495)
2. Oishi K, Uchida D & Ishida N (2008) Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver. FEBS Lett 582, 3639-3642.
3. Lundasen T, Hunt MC, Nilsson LM, et al. (2007) PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun 360, 437-440. (Pubitemid 47039157)
4. Kharitonenkov A, Shiyanova TL, Koester A, et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest 115, 1627-1635. (Pubitemid 40814671)
5. Coskun T, Bina HA, Schneider MA, et al. (2008) Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 149, 6018-6027.
6. Xu J, Lloyd DJ, Hale C, et al. (2009) Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 58, 250-259.
7. Pariza MW, Park Y & Cook ME (2001) The biologically active isomers of conjugated linoleic acid. Prog Lipid Res 40, 283-298. (Pubitemid 32547235)
8. Evans M, Lin X, Odle J, et al. (2002) Trans-10, cis-12 conjugated linoleic acid increases fatty acid oxidation in 3T3-L1 preadipocytes. J Nutr 132, 450-455. (Pubitemid 34208748)
9. Gaullier JM, Halse J, Hoye K, et al. (2005) Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr 135, 778-784. (Pubitemid 40464104)
10. Whigham LD, Watras AC & Schoeller DA (2007) Efficacy of conjugated linoleic acid for reducing fat mass: A metaanalysis in humans. Am J Clin Nutr 85, 1203-1211. (Pubitemid 46740460)
11. Brown JM, Halvorsen YD, Lea-Currie YR, et al. (2001) Trans- 10, cis-12, but not cis-9, trans-11, conjugated linoleic acid attenuates lipogenesis in primary cultures of stromal vascular cells from human adipose tissue. J Nutr 131, 2316-2321. (Pubitemid 32851875)
12. Miller JR, Siripurkpong P, Hawes J, et al. (2008) The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPARgamma-dependent and PPARgammaindependent mechanisms. J Lipid Res 49, 550-562.
13. Moya-Camarena SY, Vanden Heuvel JP, Blanchard SG, et al. (1999) Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. J Lipid Res 40, 1426-1433. (Pubitemid 29379982)
14. Konig B, Spielmann J, Haase K, et al. (2008) Effects of fish oil and conjugated linoleic acids on expression of target genes of PPAR alpha and sterol regulatory element-binding proteins in the liver of laying hens. Br J Nutr 100, 355-363.
15. Park Y, Albright KJ, Liu W, et al. (1997) Effect of conjugated linoleic acid on body composition in mice. Lipids 32, 853-858. (Pubitemid 27360392)
16. Inagaki T, Dutchak P, Zhao G, et al. (2007) Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 5, 415-425. (Pubitemid 46825496)
17. Corl BA, Mathews Oliver SA, Lin X, et al. (2008) Conjugated linoleic acid reduces body fat accretion and lipogenic gene expression in neonatal pigs fed low- or high-fat formulas. J Nutr 138, 449-454. (Pubitemid 351355239)
18. Wang Y & Jones PJ (2004) Dietary conjugated linoleic acid and body composition. Am J Clin Nutr 79, 1153S-1158S.
19. Silveira MB, Carraro R, Monereo S, et al. (2007) Conjugated linoleic acid (CLA) and obesity. Public Health Nutr 10, 1181-1186. (Pubitemid 350085207)
20. Kennedy A, Martinez K, Schmidt S, et al. (2010) Antiobesity mechanisms of action of conjugated linoleic acid. J Nutr Biochem 21, 171-179.
21. Hotta Y, Nakamura H, Konishi M, et al. (2009) Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology 150, 4625-4633.
22. Tyynismaa H, Raivio T, Hakkarainen A, et al. (2011) Liver fat but not other adiposity measures influence circulating FGF21 levels in healthy young adult twins. J Clin Endocrinol Metab 96, E351-E355.
23. Li H, Fang Q, Gao F, et al. (2010) Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. J Hepatol 53, 934-940.
24. Yu H, Xia F, Lam KS, et al. (2011) Circadian rhythm of circulating fibroblast growth factor 21 (FGF21) is related to the diurnal changes in fatty acids in humans. Clin Chem 57, 691-700.
25. Gaemers IC, Stallen JM, Kunne C, et al. (2011) Lipotoxicity and steatohepatitis in an overfed mouse model for nonalcoholic fatty liver disease. Biochim Biophys Acta 1812, 447-458.
26. Kennedy A, Chung S, LaPoint K, et al. (2008) Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes. J Nutr 138, 455-461. (Pubitemid 351355240)
27. Muise ES, Azzolina B, Kuo DW, et al. (2008) Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states. Mol Pharmacol 74, 403-412.