Mechanism-based population modelling of the effects of vildagliptin on GLP-1, glucose and insulin in patients with type 2 diabetes

British Journal of Clinical Pharmacology

Volumn 73, Issue 3, 2012, Pages 373-390

  Landersdorfer, Cornelia B ^a,b   He, Yan Ling ^c   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b MONASH UNIVERSITY   (Australia)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

GLP 1; Glucose; Insulin; Mechanism based population modelling; Type 2 diabetes mellitus; Vildagliptin

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; PLACEBO; VILDAGLIPTIN;

ANTIDIABETIC ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIABETIC PATIENT; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; GLUCOSE UTILIZATION; GLYCEMIC CONTROL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; LIMIT OF QUANTITATION; NON INSULIN DEPENDENT DIABETES MELLITUS; POPULATION MODEL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE;

ADAMANTANE; ADMINISTRATION, ORAL; ADULT; BLOOD GLUCOSE; CROSS-OVER STUDIES; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCAGON-LIKE PEPTIDE 1; HUMANS; INSULIN; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; NITRILES; PYRROLIDINES;

EID: 84863021457     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2011.04109.x     Document Type: Article

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