Substrate specificity of bacterial prolyl-tRNA synthetase editing domain is controlled by a tunable hydrophobic pocket

Journal of Biological Chemistry

Volumn 287, Issue 5, 2012, Pages 3175-3184

  Kumar, Sandeep ^a,b   Das, Mom ^a   Hadad, Christopher M ^a   Musier Forsyth, Karin ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONSERVED RESIDUES; COVALENT ATTACHMENT; EXPERIMENTAL APPROACHES; GENETIC INFORMATION; HIGH FIDELITY; HYDROPHOBIC POCKETS; IN-VIVO; MOLECULAR BASIS; SIDE-CHAINS; SITE-SPECIFIC; SUBSTRATE SPECIFICITY; SYNTHETASES;

ESCHERICHIA COLI; GENES; HYDROLYSIS; HYDROPHOBICITY; SUBSTRATES;

AMINO ACIDS;

ALANINE; BACTERIAL ENZYME; CYSTEINE; ISOLEUCINE; LEUCINE; LYSINE; PROLINE TRANSFER RIBONUCLEIC ACID SYNTHETASE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENTEROCOCCUS FAECALIS; ENZYME BINDING; ENZYME SPECIFICITY; ESCHERICHIA COLI; HYDROLYSIS; HYDROPHOBICITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS;

AMINO ACYL-TRNA SYNTHETASES; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; EVOLUTION, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 84863011899     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.313619     Document Type: Article

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